RHOC_BOVIN
ID RHOC_BOVIN Reviewed; 193 AA.
AC Q1RMJ6;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Rho-related GTP-binding protein RhoC;
DE Flags: Precursor;
GN Name=RHOC; Synonyms=ARHC;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Heart ventricle;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Regulates a signal transduction pathway linking plasma
CC membrane receptors to the assembly of focal adhesions and actin stress
CC fibers. Serves as a microtubule-dependent signal that is required for
CC the myosin contractile ring formation during cell cycle cytokinesis.
CC Regulates apical junction formation in bronchial epithelial cells (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with RTKN. Interacts with AKAP13. Interacts with
CC DIAPH1. Interacts with PKN2. Interacts with ROCK1 and ROCK2. Interacts
CC with ARHGDIA. Interacts with RIPOR1. {ECO:0000250|UniProtKB:P08134,
CC ECO:0000250|UniProtKB:Q62159}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor
CC {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cleavage furrow
CC {ECO:0000250}. Note=Translocates to the equatorial region before furrow
CC formation in a ECT2-dependent manner. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rho family.
CC {ECO:0000305}.
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DR EMBL; BC114859; AAI14860.1; -; mRNA.
DR RefSeq; NP_001039603.1; NM_001046138.2.
DR RefSeq; XP_005204165.1; XM_005204108.2.
DR RefSeq; XP_010801464.1; XM_010803162.2.
DR AlphaFoldDB; Q1RMJ6; -.
DR SMR; Q1RMJ6; -.
DR STRING; 9913.ENSBTAP00000018998; -.
DR PaxDb; Q1RMJ6; -.
DR PeptideAtlas; Q1RMJ6; -.
DR PRIDE; Q1RMJ6; -.
DR Ensembl; ENSBTAT00000018998; ENSBTAP00000018998; ENSBTAG00000014299.
DR GeneID; 513152; -.
DR KEGG; bta:513152; -.
DR CTD; 389; -.
DR VEuPathDB; HostDB:ENSBTAG00000014299; -.
DR VGNC; VGNC:55672; RHOC.
DR eggNOG; KOG0393; Eukaryota.
DR GeneTree; ENSGT00950000182945; -.
DR HOGENOM; CLU_041217_21_2_1; -.
DR InParanoid; Q1RMJ6; -.
DR OMA; APEVNHY; -.
DR OrthoDB; 1166960at2759; -.
DR TreeFam; TF300837; -.
DR Reactome; R-BTA-416482; G alpha (12/13) signalling events.
DR Reactome; R-BTA-5625900; RHO GTPases activate CIT.
DR Reactome; R-BTA-5663220; RHO GTPases Activate Formins.
DR Reactome; R-BTA-9013106; RHOC GTPase cycle.
DR Proteomes; UP000009136; Chromosome 3.
DR Bgee; ENSBTAG00000014299; Expressed in corpus epididymis and 103 other tissues.
DR GO; GO:0005938; C:cell cortex; IBA:GO_Central.
DR GO; GO:0042995; C:cell projection; IBA:GO_Central.
DR GO; GO:0032154; C:cleavage furrow; ISS:UniProtKB.
DR GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0032420; C:stereocilium; ISS:UniProtKB.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR GO; GO:0043297; P:apical junction assembly; ISS:UniProtKB.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR GO; GO:0030865; P:cortical cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0007163; P:establishment or maintenance of cell polarity; IBA:GO_Central.
DR GO; GO:0000281; P:mitotic cytokinesis; ISS:UniProtKB.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR GO; GO:0060193; P:positive regulation of lipase activity; IEA:Ensembl.
DR GO; GO:0031334; P:positive regulation of protein-containing complex assembly; ISS:UniProtKB.
DR GO; GO:0051496; P:positive regulation of stress fiber assembly; IEA:Ensembl.
DR GO; GO:0032956; P:regulation of actin cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0008360; P:regulation of cell shape; IBA:GO_Central.
DR GO; GO:1902766; P:skeletal muscle satellite cell migration; ISS:AgBase.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR GO; GO:0044319; P:wound healing, spreading of cells; ISS:AgBase.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR InterPro; IPR003578; Small_GTPase_Rho.
DR PANTHER; PTHR24072; PTHR24072; 1.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51420; RHO; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; GTP-binding; Lipoprotein; Membrane; Methylation;
KW Nucleotide-binding; Prenylation; Reference proteome.
FT CHAIN 1..190
FT /note="Rho-related GTP-binding protein RhoC"
FT /id="PRO_0000265728"
FT PROPEP 191..193
FT /note="Removed in mature form"
FT /evidence="ECO:0000250"
FT /id="PRO_0000265729"
FT MOTIF 34..42
FT /note="Effector region"
FT /evidence="ECO:0000255"
FT BINDING 12..19
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 59..63
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 117..120
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT MOD_RES 190
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250"
FT LIPID 190
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 193 AA; 22006 MW; A193DA581560F131 CRC64;
MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYIADIEVDG KQVELALWDT
AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT PEVKHFCPNV PIILVGNKKD
LRQDEHTRRE LAKMKQEPVR SEEGRDMANR ISAFGYLECS AKTKEGVREV FEMATRAGLQ
VRKNKRRRGC PIL
