RHOC_CHICK
ID RHOC_CHICK Reviewed; 193 AA.
AC Q9PSX7;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Rho-related GTP-binding protein RhoC;
DE Flags: Precursor;
GN Name=RHOC; Synonyms=ARHC;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], ADP-RIBOSYLATION, AND DEVELOPMENTAL STAGE.
RC STRAIN=Hamburger-Hamilton; TISSUE=Embryo;
RX PubMed=9811589; DOI=10.1242/dev.125.24.5055;
RA Liu J.-P., Jessell T.M.;
RT "A role for rhoB in the delamination of neural crest cells from the dorsal
RT neural tube.";
RL Development 125:5055-5067(1998).
CC -!- FUNCTION: Regulates a signal transduction pathway linking plasma
CC membrane receptors to the assembly of focal adhesions and actin stress
CC fibers. Serves as a microtubule-dependent signal that is required for
CC the myosin contractile ring formation during cell cycle cytokinesis.
CC Regulates apical junction formation in bronchial epithelial cells (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cleavage furrow
CC {ECO:0000250}. Note=Translocates to the equatorial region before furrow
CC formation in a ECT2-dependent manner. {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: Detected in embryonic notochord.
CC {ECO:0000269|PubMed:9811589}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rho family.
CC {ECO:0000305}.
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DR EMBL; AF098514; AAD12256.1; -; mRNA.
DR RefSeq; NP_001025020.1; NM_001029849.1.
DR PDB; 4D0B; X-ray; 2.80 A; C=60-69.
DR PDBsum; 4D0B; -.
DR AlphaFoldDB; Q9PSX7; -.
DR SMR; Q9PSX7; -.
DR STRING; 9031.ENSGALP00000002383; -.
DR PaxDb; Q9PSX7; -.
DR Ensembl; ENSGALT00000002385; ENSGALP00000002383; ENSGALG00000001569.
DR GeneID; 395869; -.
DR KEGG; gga:395869; -.
DR CTD; 389; -.
DR VEuPathDB; HostDB:geneid_395869; -.
DR eggNOG; KOG0393; Eukaryota.
DR GeneTree; ENSGT00950000182945; -.
DR HOGENOM; CLU_041217_21_2_1; -.
DR InParanoid; Q9PSX7; -.
DR OMA; KINACAY; -.
DR OrthoDB; 1166960at2759; -.
DR PhylomeDB; Q9PSX7; -.
DR Reactome; R-GGA-416482; G alpha (12/13) signalling events.
DR Reactome; R-GGA-416572; Sema4D induced cell migration and growth-cone collapse.
DR Reactome; R-GGA-5625740; RHO GTPases activate PKNs.
DR Reactome; R-GGA-5627117; RHO GTPases Activate ROCKs.
DR Reactome; R-GGA-5663220; RHO GTPases Activate Formins.
DR Reactome; R-GGA-9013106; RHOC GTPase cycle.
DR PRO; PR:Q9PSX7; -.
DR Proteomes; UP000000539; Chromosome 26.
DR Bgee; ENSGALG00000001569; Expressed in heart and 12 other tissues.
DR GO; GO:0005938; C:cell cortex; IBA:GO_Central.
DR GO; GO:0042995; C:cell projection; IBA:GO_Central.
DR GO; GO:0032154; C:cleavage furrow; ISS:UniProtKB.
DR GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR GO; GO:0043297; P:apical junction assembly; ISS:UniProtKB.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR GO; GO:0030865; P:cortical cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0007163; P:establishment or maintenance of cell polarity; IBA:GO_Central.
DR GO; GO:0000281; P:mitotic cytokinesis; ISS:UniProtKB.
DR GO; GO:0032956; P:regulation of actin cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0008360; P:regulation of cell shape; IBA:GO_Central.
DR GO; GO:1902766; P:skeletal muscle satellite cell migration; ISS:AgBase.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR GO; GO:0044319; P:wound healing, spreading of cells; ISS:AgBase.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR InterPro; IPR003578; Small_GTPase_Rho.
DR PANTHER; PTHR24072; PTHR24072; 1.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51420; RHO; 1.
PE 1: Evidence at protein level;
KW 3D-structure; ADP-ribosylation; Cell membrane; GTP-binding; Lipoprotein;
KW Membrane; Methylation; Nucleotide-binding; Prenylation; Reference proteome.
FT CHAIN 1..190
FT /note="Rho-related GTP-binding protein RhoC"
FT /id="PRO_0000276771"
FT PROPEP 191..193
FT /note="Removed in mature form"
FT /evidence="ECO:0000250"
FT /id="PRO_0000276772"
FT MOTIF 34..42
FT /note="Effector region"
FT /evidence="ECO:0000255"
FT BINDING 12..19
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 59..63
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 117..120
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT MOD_RES 41
FT /note="ADP-ribosylasparagine; by botulinum toxin"
FT /evidence="ECO:0000250"
FT MOD_RES 190
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250"
FT LIPID 190
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
FT HELIX 64..67
FT /evidence="ECO:0007829|PDB:4D0B"
SQ SEQUENCE 193 AA; 21973 MW; 358E9BD3AE3813A6 CRC64;
MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYIADIEVDG KQVELALWDT
AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT PEVKHFCPNV PIILVGNKKD
LRNDEHTRRE LAKMKQEPVK PEEGRDMANR INAFGYLECS AKTKEGVREV FEMATRAGLQ
VRKNKKRRGC PLL
