RHOF_BOVIN
ID RHOF_BOVIN Reviewed; 215 AA.
AC Q3SZA1;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Rho-related GTP-binding protein RhoF;
DE Flags: Precursor;
GN Name=RHOF;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plasma membrane-associated small GTPase which cycles between
CC an active GTP-bound and an inactive GDP-bound state. Causes the
CC formation of thin, actin-rich surface projections called filopodia.
CC Functions cooperatively with CDC42 and Rac to generate additional
CC structures, increasing the diversity of actin-based morphology (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm, cytoskeleton
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rho family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC103016; AAI03017.1; -; mRNA.
DR RefSeq; NP_001035692.1; NM_001040602.2.
DR RefSeq; XP_005217997.1; XM_005217940.3.
DR RefSeq; XP_005217998.1; XM_005217941.3.
DR RefSeq; XP_005218000.1; XM_005217943.3.
DR RefSeq; XP_005218002.1; XM_005217945.3.
DR RefSeq; XP_005218004.1; XM_005217947.3.
DR RefSeq; XP_005218006.1; XM_005217949.3.
DR RefSeq; XP_010812283.1; XM_010813981.2.
DR RefSeq; XP_010812284.1; XM_010813982.2.
DR AlphaFoldDB; Q3SZA1; -.
DR SMR; Q3SZA1; -.
DR STRING; 9913.ENSBTAP00000043485; -.
DR PaxDb; Q3SZA1; -.
DR PRIDE; Q3SZA1; -.
DR Ensembl; ENSBTAT00000046161; ENSBTAP00000043485; ENSBTAG00000032534.
DR GeneID; 617894; -.
DR KEGG; bta:617894; -.
DR CTD; 54509; -.
DR VEuPathDB; HostDB:ENSBTAG00000032534; -.
DR VGNC; VGNC:33948; RHOF.
DR eggNOG; KOG0393; Eukaryota.
DR GeneTree; ENSGT00940000158903; -.
DR HOGENOM; CLU_041217_21_2_1; -.
DR InParanoid; Q3SZA1; -.
DR OMA; ECSAKHQ; -.
DR OrthoDB; 1091615at2759; -.
DR TreeFam; TF331746; -.
DR Reactome; R-BTA-6798695; Neutrophil degranulation.
DR Reactome; R-BTA-9035034; RHOF GTPase cycle.
DR Proteomes; UP000009136; Chromosome 17.
DR Bgee; ENSBTAG00000032534; Expressed in mesenteric lymph node and 105 other tissues.
DR GO; GO:0005938; C:cell cortex; IBA:GO_Central.
DR GO; GO:0042995; C:cell projection; IBA:GO_Central.
DR GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR GO; GO:0030865; P:cortical cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0007163; P:establishment or maintenance of cell polarity; IBA:GO_Central.
DR GO; GO:0032956; P:regulation of actin cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0008360; P:regulation of cell shape; IBA:GO_Central.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR InterPro; IPR003578; Small_GTPase_Rho.
DR PANTHER; PTHR24072; PTHR24072; 1.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51420; RHO; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Cell membrane; Cytoplasm; Cytoskeleton; GTP-binding;
KW Lipoprotein; Membrane; Methylation; Nucleotide-binding; Prenylation;
KW Reference proteome.
FT CHAIN 1..212
FT /note="Rho-related GTP-binding protein RhoF"
FT /id="PRO_0000284912"
FT PROPEP 213..215
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000284913"
FT MOTIF 52..60
FT /note="Effector region"
FT /evidence="ECO:0000255"
FT BINDING 30..37
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 77..81
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 135..138
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9HBH0"
FT MOD_RES 212
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000255"
FT LIPID 212
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 215 AA; 23841 MW; 94FAEFB02A0A21C1 CRC64;
MDAAGAPAPA PAPPAAPGSG RKELKIVIVG DGGCGKTSLL MVYSQGSFPE HYAPSVFEKY
TASVTVGSKE VTLNLYDTAG QEDYDRLRPL SYQNTHLVLI CYDVMNPTSY DNVLIKWFPE
VTHFCRGIPM VLIGCKTDLR KDKEQLRKLR AAQLEPITYT QGQSACEQIR AALYLECSAK
FRENVEDVFR EAAKVALSAL KKAQRQKQHR LCLLL