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RHOF_BOVIN
ID   RHOF_BOVIN              Reviewed;         215 AA.
AC   Q3SZA1;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Rho-related GTP-binding protein RhoF;
DE   Flags: Precursor;
GN   Name=RHOF;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plasma membrane-associated small GTPase which cycles between
CC       an active GTP-bound and an inactive GDP-bound state. Causes the
CC       formation of thin, actin-rich surface projections called filopodia.
CC       Functions cooperatively with CDC42 and Rac to generate additional
CC       structures, increasing the diversity of actin-based morphology (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm, cytoskeleton
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rho family.
CC       {ECO:0000305}.
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DR   EMBL; BC103016; AAI03017.1; -; mRNA.
DR   RefSeq; NP_001035692.1; NM_001040602.2.
DR   RefSeq; XP_005217997.1; XM_005217940.3.
DR   RefSeq; XP_005217998.1; XM_005217941.3.
DR   RefSeq; XP_005218000.1; XM_005217943.3.
DR   RefSeq; XP_005218002.1; XM_005217945.3.
DR   RefSeq; XP_005218004.1; XM_005217947.3.
DR   RefSeq; XP_005218006.1; XM_005217949.3.
DR   RefSeq; XP_010812283.1; XM_010813981.2.
DR   RefSeq; XP_010812284.1; XM_010813982.2.
DR   AlphaFoldDB; Q3SZA1; -.
DR   SMR; Q3SZA1; -.
DR   STRING; 9913.ENSBTAP00000043485; -.
DR   PaxDb; Q3SZA1; -.
DR   PRIDE; Q3SZA1; -.
DR   Ensembl; ENSBTAT00000046161; ENSBTAP00000043485; ENSBTAG00000032534.
DR   GeneID; 617894; -.
DR   KEGG; bta:617894; -.
DR   CTD; 54509; -.
DR   VEuPathDB; HostDB:ENSBTAG00000032534; -.
DR   VGNC; VGNC:33948; RHOF.
DR   eggNOG; KOG0393; Eukaryota.
DR   GeneTree; ENSGT00940000158903; -.
DR   HOGENOM; CLU_041217_21_2_1; -.
DR   InParanoid; Q3SZA1; -.
DR   OMA; ECSAKHQ; -.
DR   OrthoDB; 1091615at2759; -.
DR   TreeFam; TF331746; -.
DR   Reactome; R-BTA-6798695; Neutrophil degranulation.
DR   Reactome; R-BTA-9035034; RHOF GTPase cycle.
DR   Proteomes; UP000009136; Chromosome 17.
DR   Bgee; ENSBTAG00000032534; Expressed in mesenteric lymph node and 105 other tissues.
DR   GO; GO:0005938; C:cell cortex; IBA:GO_Central.
DR   GO; GO:0042995; C:cell projection; IBA:GO_Central.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR   GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR   GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR   GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR   GO; GO:0030865; P:cortical cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0007163; P:establishment or maintenance of cell polarity; IBA:GO_Central.
DR   GO; GO:0032956; P:regulation of actin cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0008360; P:regulation of cell shape; IBA:GO_Central.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR003578; Small_GTPase_Rho.
DR   PANTHER; PTHR24072; PTHR24072; 1.
DR   Pfam; PF00071; Ras; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51420; RHO; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cell membrane; Cytoplasm; Cytoskeleton; GTP-binding;
KW   Lipoprotein; Membrane; Methylation; Nucleotide-binding; Prenylation;
KW   Reference proteome.
FT   CHAIN           1..212
FT                   /note="Rho-related GTP-binding protein RhoF"
FT                   /id="PRO_0000284912"
FT   PROPEP          213..215
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000284913"
FT   MOTIF           52..60
FT                   /note="Effector region"
FT                   /evidence="ECO:0000255"
FT   BINDING         30..37
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         77..81
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         135..138
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9HBH0"
FT   MOD_RES         212
FT                   /note="Cysteine methyl ester"
FT                   /evidence="ECO:0000255"
FT   LIPID           212
FT                   /note="S-geranylgeranyl cysteine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   215 AA;  23841 MW;  94FAEFB02A0A21C1 CRC64;
     MDAAGAPAPA PAPPAAPGSG RKELKIVIVG DGGCGKTSLL MVYSQGSFPE HYAPSVFEKY
     TASVTVGSKE VTLNLYDTAG QEDYDRLRPL SYQNTHLVLI CYDVMNPTSY DNVLIKWFPE
     VTHFCRGIPM VLIGCKTDLR KDKEQLRKLR AAQLEPITYT QGQSACEQIR AALYLECSAK
     FRENVEDVFR EAAKVALSAL KKAQRQKQHR LCLLL
 
 
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