RHOX5_MOUSE
ID RHOX5_MOUSE Reviewed; 210 AA.
AC P52651;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 25-MAY-2022, entry version 114.
DE RecName: Full=Homeobox protein Rhox5;
DE AltName: Full=Homeobox protein Pem;
DE AltName: Full=Placenta and embryonic expression protein;
DE AltName: Full=Reproductive homeobox on chromosome X 5;
GN Name=Rhox5; Synonyms=Pem;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC STRAIN=AKR/J;
RX PubMed=2210045; DOI=10.1016/0012-1606(90)90400-d;
RA Wilkinson M.F., Kleenman J., Richards J., Macleod C.L.;
RT "A novel oncofetal gene is expressed in a stage-specific manner in murine
RT embryonic development.";
RL Dev. Biol. 141:451-455(1990).
RN [2]
RP ERRATUM OF PUBMED:2210045.
RX PubMed=1840518; DOI=10.1016/0012-1606(91)90469-j;
RA Wilkinson M.F., Kleenman J., Richards J., Macleod C.L.;
RL Dev. Biol. 146:263-263(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=AKR/J;
RX PubMed=1680379; DOI=10.1016/0925-4773(91)90052-8;
RA Sasaki A.W., Doskow J., Macleod C.L., Rogers M.B., Gudas L.J.,
RA Wilkinson M.F.;
RT "The oncofetal gene Pem encodes a homeodomain and is regulated in
RT primordial and pre-muscle stem cells.";
RL Mech. Dev. 34:155-164(1991).
RN [4]
RP NUCLEOTIDE SEQUENCE OF 1-161.
RC STRAIN=BALB/cJ;
RA Sutton K.A.;
RL Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP DISCUSSION OF HOMEOBOX SEQUENCE.
RX PubMed=1676380; DOI=10.1016/0012-1606(91)90467-h;
RA Rayle R.E.;
RT "The oncofetal gene Pem specifies a divergent paired class homeodomain.";
RL Dev. Biol. 146:255-257(1991).
RN [6]
RP FUNCTION, AND INDUCTION.
RX PubMed=24074865; DOI=10.1016/j.cell.2013.08.056;
RA Neri F., Krepelova A., Incarnato D., Maldotti M., Parlato C., Galvagni F.,
RA Matarese F., Stunnenberg H.G., Oliviero S.;
RT "Dnmt3L antagonizes DNA methylation at bivalent promoters and favors DNA
RT methylation at gene bodies in ESCs.";
RL Cell 155:121-134(2013).
CC -!- FUNCTION: Transcription factor required for differentiation of
CC embryonic stem cells (ESCs) into primordial germ cells.
CC {ECO:0000269|PubMed:24074865}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed in a stage specific manner during murine
CC ontogeny. Not detectably expressed in adult tissues.
CC {ECO:0000269|PubMed:2210045}.
CC -!- INDUCTION: Expression in embryonic stem cells (ESCs) is dependent on
CC DNMT3L, which mnaintains a low DNA methylation on promoters, allowing
CC its expression. {ECO:0000269|PubMed:24074865}.
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DR EMBL; M32484; AAC42025.1; -; mRNA.
DR EMBL; U50747; AAA96048.1; -; Genomic_DNA.
DR CCDS; CCDS57752.1; -.
DR PIR; A49770; A37358.
DR AlphaFoldDB; P52651; -.
DR SMR; P52651; -.
DR STRING; 10090.ENSMUSP00000139179; -.
DR iPTMnet; P52651; -.
DR PhosphoSitePlus; P52651; -.
DR MaxQB; P52651; -.
DR PaxDb; P52651; -.
DR PeptideAtlas; P52651; -.
DR PRIDE; P52651; -.
DR ProteomicsDB; 253237; -.
DR MGI; MGI:97538; Rhox5.
DR InParanoid; P52651; -.
DR ChiTaRS; Rhox5; mouse.
DR PRO; PR:P52651; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P52651; protein.
DR GO; GO:0000785; C:chromatin; IC:MGI.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005634; C:nucleus; IDA:CACAO.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0035234; P:ectopic germ cell programmed cell death; IMP:MGI.
DR GO; GO:0048484; P:enteric nervous system development; IBA:GO_Central.
DR GO; GO:0030317; P:flagellated sperm motility; IMP:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR040069; Rhox5.
DR PANTHER; PTHR47465:SF4; PTHR47465:SF4; 1.
DR SMART; SM00389; HOX; 1.
PE 2: Evidence at transcript level;
KW Differentiation; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..210
FT /note="Homeobox protein Rhox5"
FT /id="PRO_0000049243"
FT DNA_BIND 117..175
FT /note="Homeobox; atypical"
FT REGION 1..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..36
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 210 AA; 23045 MW; D52780B7C8A4E690 CRC64;
MEAEGSSRKV TRLLRLGVKE DSEEQHDVKA EAFFQAGEGR DEQGAQGQPG VGAVGTEGEG
EELNGGKGHF GPGAPGPMGD GDKDSGTRAG GVEQEQNEPV AEGTESQENG NPGGRQMPLQ
GSRFAQHRLR ELESILQRTN SFDVPREDLD RLMDACVSRV QNWFKIRRAA ARRTRRRATP
VPEHFRGTFE CPACRGVRWG ERCPFATPRF
