ID   RHOX5_MUSMI             Reviewed;         210 AA.
AC   Q9QYR2;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Homeobox protein Rhox5;
DE   AltName: Full=Homeobox protein Pem;
DE   AltName: Full=Placenta and embryonic expression protein;
DE   AltName: Full=Reproductive homeobox on chromosome X 5;
GN   Name=Rhox5; Synonyms=Pem;
OS   Mus minutoides (Southern African pygmy mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Nannomys.
OX   NCBI_TaxID=10105;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9419235; DOI=10.1007/pl00006262;
RA   Sutton K.A., Wilkinson M.F.;
RT   "Rapid evolution of a homeodomain: evidence for positive selection.";
RL   J. Mol. Evol. 45:579-588(1997).
CC   -!- FUNCTION: Transcription factor required for differentiation of
CC       embryonic stem cells (ESCs) into primordial germ cells.
CC       {ECO:0000250|UniProtKB:P52651}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF189315; AAF00510.1; -; Genomic_DNA.
DR   EMBL; AF189314; AAF00510.1; JOINED; Genomic_DNA.
DR   AlphaFoldDB; Q9QYR2; -.
DR   SMR; Q9QYR2; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR040069; Rhox5.
DR   PANTHER; PTHR47465:SF4; PTHR47465:SF4; 1.
DR   SMART; SM00389; HOX; 1.
PE   3: Inferred from homology;
KW   Differentiation; DNA-binding; Homeobox; Nucleus.
FT   CHAIN           1..210
FT                   /note="Homeobox protein Rhox5"
FT                   /id="PRO_0000257864"
FT   DNA_BIND        117..175
FT                   /note="Homeobox; atypical"
FT   REGION          29..117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   210 AA;  23221 MW;  D6C2EF95C63A5790 CRC64;
     MEAQSSSRQV TGPLYLGVKE DWEEQHDVKA EAFLQAGEGR KEKGAQGQPG VGAVGKEGEG
     EELSGGEGQF GPGAPGPMGD EDKDGGTRAG GVEEEQNEPA AEGTESQKNG KPEDRQMPLQ
     GSRFAQQRLS ELQSILQRTN SFDVPREDLY RLMDTCVARV QNWFKIRRAA ARRNRRRTTP
     VPEHFRGTFE CPACRGVRWG ERCPFATPRF