ID   RHOX5_RAT               Reviewed;         211 AA.
AC   Q63630; P97736; Q4TU77;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Homeobox protein Rhox5;
DE   AltName: Full=Homeobox protein Pem;
DE   AltName: Full=Placenta and embryonic expression protein;
DE   AltName: Full=Reproductive homeobox on chromosome X 5;
GN   Name=Rhox5; Synonyms=Pem;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Fibroblast;
RX   PubMed=8663309; DOI=10.1074/jbc.271.29.17536;
RA   Maiti S., Doskow J., Li S., Nhim R.P., Lindsey J.S., Wilkinson M.F.;
RT   "The Pem homeobox gene. Androgen-dependent and -independent promoters and
RT   tissue-specific alternative RNA splicing.";
RL   J. Biol. Chem. 271:17536-17546(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Fibroblast;
RX   PubMed=8786129; DOI=10.1006/geno.1996.0291;
RA   Maiti S., Doskow J., Sutton K., Nhim R.P., Lawlor D.A., Levan K.,
RA   Lindsey J.S., Wilkinson M.F.;
RT   "The Pem homeobox gene: rapid evolution of the homeodomain, X chromosomal
RT   localization, and expression in reproductive tissue.";
RL   Genomics 34:304-316(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley;
RA   Maclean J.A. II, Bruce S.R., Wilkinson M.F.;
RT   "Rhox: a new homeobox gene cluster on the rat X chromosome.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor required for differentiation of
CC       embryonic stem cells (ESCs) into primordial germ cells.
CC       {ECO:0000250|UniProtKB:P52651}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in placenta. Lower levels in
CC       testis, epididymis, ovary and skeletal muscle.
CC   -!- DEVELOPMENTAL STAGE: Expressed during embryogenesis and in adult
CC       reproductive tissue and skeletal muscle.
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DR   EMBL; U52034; AAC52665.1; -; Genomic_DNA.
DR   EMBL; DQ058653; AAY58264.1; -; mRNA.
DR   RefSeq; NP_071511.1; NM_022175.1.
DR   AlphaFoldDB; Q63630; -.
DR   SMR; Q63630; -.
DR   STRING; 10116.ENSRNOP00000064947; -.
DR   PaxDb; Q63630; -.
DR   GeneID; 24631; -.
DR   KEGG; rno:24631; -.
DR   CTD; 18617; -.
DR   RGD; 3295; Rhox5.
DR   HOGENOM; CLU_1304540_0_0_1; -.
DR   InParanoid; Q63630; -.
DR   OMA; PEHFRAT; -.
DR   OrthoDB; 1438623at2759; -.
DR   PRO; PR:Q63630; -.
DR   Proteomes; UP000002494; Chromosome X.
DR   Bgee; ENSRNOG00000046548; Expressed in quadriceps femoris and 12 other tissues.
DR   ExpressionAtlas; Q63630; baseline and differential.
DR   Genevisible; Q63630; RN.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   InterPro; IPR040069; Rhox5.
DR   PANTHER; PTHR47465:SF4; PTHR47465:SF4; 1.
PE   2: Evidence at transcript level;
KW   Differentiation; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..211
FT                   /note="Homeobox protein Rhox5"
FT                   /id="PRO_0000049244"
FT   DNA_BIND        119..176
FT                   /note="Homeobox; atypical"
FT   REGION          38..129
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        91..123
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   211 AA;  22850 MW;  3184B9FEAA0E1D71 CRC64;
     MEAQGSSHDI SRLLCLGVKE DSEEQHGQYL GDVKAEAFFQ AGEGRDEKGA QGQPGEGAVG
     TEGEGEELNG GEGHFGPGVP GPVGEGDKDG GTRASGMEEE QHEPVAEGTE SVKSEDKQMP
     LRRPGSTQRR LAELERILLS SGSSSGGRSL IDGWISVCPE CRNWFKIRRA AYRRNRRRRT
     PIPEHFRATS GCPACLGARW GVRCPFATPR F