RHP41_SCHPO
ID RHP41_SCHPO Reviewed; 638 AA.
AC Q10445;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 25-MAY-2022, entry version 130.
DE RecName: Full=DNA repair protein rhp41;
GN Name=rhp41; Synonyms=rhp4a; ORFNames=SPAC12B10.12c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION.
RX PubMed=12807767; DOI=10.1093/genetics/164.2.457;
RA Marti T.M., Kunz C., Fleck O.;
RT "Repair of damaged and mismatched DNA by the XPC homologues Rhp41 and Rhp42
RT of fission yeast.";
RL Genetics 164:457-467(2003).
RN [3]
RP FUNCTION.
RX PubMed=12531030; DOI=10.1016/s1568-7864(02)00108-8;
RA Fukumoto Y., Hiyama H., Yokoi M., Nakaseko Y., Yanagida M., Hanaoka F.;
RT "Two budding yeast RAD4 homologs in fission yeast play different roles in
RT the repair of UV-induced DNA damage.";
RL DNA Repair 1:833-845(2002).
CC -!- FUNCTION: Has a role in the nucleotide excision repair (NER) pathway.
CC Acts in both transcription-coupled repair (TCR) which removes damage
CC from the transcribed strand of active genes and in global genome repair
CC (GGR) which removes damage in untranscribed DNA. Involved in the repair
CC of UV-induced damages where it is involved in the removal of
CC cyclobutane pyrimidine dimers (CPDs). {ECO:0000269|PubMed:12531030,
CC ECO:0000269|PubMed:12807767}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the XPC family. {ECO:0000305}.
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DR EMBL; CU329670; CAA94702.1; -; Genomic_DNA.
DR PIR; T37579; T37579.
DR RefSeq; NP_594644.1; NM_001020072.2.
DR AlphaFoldDB; Q10445; -.
DR SMR; Q10445; -.
DR BioGRID; 279407; 28.
DR STRING; 4896.SPAC12B10.12c.1; -.
DR MaxQB; Q10445; -.
DR PaxDb; Q10445; -.
DR EnsemblFungi; SPAC12B10.12c.1; SPAC12B10.12c.1:pep; SPAC12B10.12c.
DR GeneID; 2542967; -.
DR KEGG; spo:SPAC12B10.12c; -.
DR PomBase; SPAC12B10.12c; rhp41.
DR VEuPathDB; FungiDB:SPAC12B10.12c; -.
DR eggNOG; KOG2179; Eukaryota.
DR HOGENOM; CLU_003639_0_0_1; -.
DR InParanoid; Q10445; -.
DR OMA; SYVIAFE; -.
DR PhylomeDB; Q10445; -.
DR PRO; PR:Q10445; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0072686; C:mitotic spindle; HDA:PomBase.
DR GO; GO:0000111; C:nucleotide-excision repair factor 2 complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0071942; C:XPC complex; IBA:GO_Central.
DR GO; GO:0003684; F:damaged DNA binding; IBA:GO_Central.
DR GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0006298; P:mismatch repair; IGI:PomBase.
DR GO; GO:0006289; P:nucleotide-excision repair; IGI:PomBase.
DR Gene3D; 3.30.70.2460; -; 1.
DR Gene3D; 3.90.260.10; -; 1.
DR InterPro; IPR018327; BHD_2.
DR InterPro; IPR004583; DNA_repair_Rad4.
DR InterPro; IPR018026; DNA_repair_Rad4_subgr.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR018325; Rad4/PNGase_transGLS-fold.
DR InterPro; IPR018326; Rad4_beta-hairpin_dom1.
DR InterPro; IPR018328; Rad4_beta-hairpin_dom3.
DR InterPro; IPR042488; Rad4_BHD3_sf.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR PANTHER; PTHR12135; PTHR12135; 1.
DR Pfam; PF10403; BHD_1; 1.
DR Pfam; PF10405; BHD_3; 1.
DR Pfam; PF03835; Rad4; 1.
DR SMART; SM01030; BHD_1; 1.
DR SMART; SM01031; BHD_2; 1.
DR SMART; SM01032; BHD_3; 1.
DR SUPFAM; SSF54001; SSF54001; 1.
DR TIGRFAMs; TIGR00605; rad4; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair; DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..638
FT /note="DNA repair protein rhp41"
FT /id="PRO_0000218296"
SQ SEQUENCE 638 AA; 73519 MW; E9A5AD4ECB7F812E CRC64;
MMSDEDNTYS DDEEWLDLDL GLPNNDIKTA PILNSSLLSS AVHGERLIQE RPTHDFGDVE
ATVDRTVEKR SRLKITSVDR KIRLQIHQLH LLCLTYHLCT RNTWCDDNRL NYLVKYIPPG
IRVSLHPSSQ KSQMIRNKTF LHGLAGLVEV WKRKYKITTN GLRKPNYGLL QNNSLISESL
SLEEFCKNSK LLSGSRDYGT QLFASILRNL NVPTRLVFSL QVLSFRFKGA INEASSHEIV
PAWSQQMEND SSSDISESAH ITSRFRKRRK IIQPSFSNLS HLDASDIVTE DTKLKVIDSP
KPVFWVEAFN KAMQKWVCVD PFGDASVIGK YRRFEPASSD HLNQMTYVFA IEANGYVKDV
TRKYCLHYYK ILKNRVEIFP FGKAWMNRIF SKIGKPRDFY NDMDAIEDAE LLRLEQSEGI
PRNIQDLKDH PLFVLERHLK KNQAIKTGKS CGRINTKNGV ELVYPRKYVS NGFSAEHWYR
KGRIIKPGAQ PLKHVKNGDK VLPLYDEEAT QLYTPKPVVA NIVPKNAYGN IDLYVPSMLP
YGAYHCRKRC ALAAAKFLEI DYAKAVVGFD FQRKYSKPKL EGVVVSKRYE EAIDLIAEEI
DQEEKEAEAR NVRKTCLLLW KRLITGLRIR QRVFEEYG
