RHP42_SCHPO
ID RHP42_SCHPO Reviewed; 686 AA.
AC P87235;
DT 25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 25-MAY-2022, entry version 126.
DE RecName: Full=DNA repair protein rhp42;
GN Name=rhp42; Synonyms=rhp4b; ORFNames=SPCC4G3.10c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION.
RX PubMed=12807767; DOI=10.1093/genetics/164.2.457;
RA Marti T.M., Kunz C., Fleck O.;
RT "Repair of damaged and mismatched DNA by the XPC homologues Rhp41 and Rhp42
RT of fission yeast.";
RL Genetics 164:457-467(2003).
RN [3]
RP FUNCTION.
RX PubMed=12531030; DOI=10.1016/s1568-7864(02)00108-8;
RA Fukumoto Y., Hiyama H., Yokoi M., Nakaseko Y., Yanagida M., Hanaoka F.;
RT "Two budding yeast RAD4 homologs in fission yeast play different roles in
RT the repair of UV-induced DNA damage.";
RL DNA Repair 1:833-845(2002).
CC -!- FUNCTION: Has a role in the nucleotide excision repair (NER) pathway.
CC Acts in both transcription-coupled repair (TCR) which removes damage
CC from the transcribed strand of active genes and in global genome repair
CC (GGR) which removes damage in untranscribed DNA. Involved in the repair
CC of short-patch mismatch during meiosis. {ECO:0000269|PubMed:12531030,
CC ECO:0000269|PubMed:12807767}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the XPC family. {ECO:0000305}.
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DR EMBL; CU329672; CAB09777.1; -; Genomic_DNA.
DR PIR; T41366; T41366.
DR RefSeq; NP_587828.1; NM_001022821.2.
DR AlphaFoldDB; P87235; -.
DR SMR; P87235; -.
DR BioGRID; 276028; 6.
DR STRING; 4896.SPCC4G3.10c.1; -.
DR PaxDb; P87235; -.
DR EnsemblFungi; SPCC4G3.10c.1; SPCC4G3.10c.1:pep; SPCC4G3.10c.
DR GeneID; 2539465; -.
DR KEGG; spo:SPCC4G3.10c; -.
DR PomBase; SPCC4G3.10c; rhp42.
DR VEuPathDB; FungiDB:SPCC4G3.10c; -.
DR eggNOG; KOG2179; Eukaryota.
DR HOGENOM; CLU_003639_2_1_1; -.
DR InParanoid; P87235; -.
DR OMA; AKQVICY; -.
DR PhylomeDB; P87235; -.
DR Reactome; R-SPO-3108214; SUMOylation of DNA damage response and repair proteins.
DR Reactome; R-SPO-5696395; Formation of Incision Complex in GG-NER.
DR PRO; PR:P87235; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR GO; GO:0000111; C:nucleotide-excision repair factor 2 complex; IBA:GO_Central.
DR GO; GO:0071942; C:XPC complex; IBA:GO_Central.
DR GO; GO:0003684; F:damaged DNA binding; ISO:PomBase.
DR GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0006298; P:mismatch repair; IGI:PomBase.
DR GO; GO:0006289; P:nucleotide-excision repair; IGI:PomBase.
DR Gene3D; 3.30.70.2460; -; 1.
DR Gene3D; 3.90.260.10; -; 1.
DR InterPro; IPR018327; BHD_2.
DR InterPro; IPR004583; DNA_repair_Rad4.
DR InterPro; IPR018026; DNA_repair_Rad4_subgr.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR018325; Rad4/PNGase_transGLS-fold.
DR InterPro; IPR018326; Rad4_beta-hairpin_dom1.
DR InterPro; IPR018328; Rad4_beta-hairpin_dom3.
DR InterPro; IPR042488; Rad4_BHD3_sf.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR PANTHER; PTHR12135; PTHR12135; 2.
DR Pfam; PF10403; BHD_1; 1.
DR Pfam; PF10404; BHD_2; 1.
DR Pfam; PF10405; BHD_3; 1.
DR Pfam; PF03835; Rad4; 1.
DR SMART; SM01030; BHD_1; 1.
DR SMART; SM01031; BHD_2; 1.
DR SMART; SM01032; BHD_3; 1.
DR SUPFAM; SSF54001; SSF54001; 1.
DR TIGRFAMs; TIGR00605; rad4; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair; DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..686
FT /note="DNA repair protein rhp42"
FT /id="PRO_0000218297"
FT REGION 1..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..79
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 686 AA; 79024 MW; ABFE117151E1702F CRC64;
MPPKRKASKN SVRGRKRRTR TNNLPLNPEV KEETVVSSTH RQTRSQSKKP SLSSSAEPPS
ESLDDNISAL NSLQRSASSS EKGSDEDNEK LGSSEDDEFD DDFDTWEQVD LSPNKQEDKK
DLHIVTQHIT PQLTKESKKG SSSAMDKSIR LSIHIMHFTC LLYHGSVRNR WLMNSLLLDG
LRDLLVEKQP SVVEAWVCSS QTHEDLLKLL NGLRMWWNKS FKIESHGLRK LGYRTLKQGF
DIGFSPEIFH NFHEYQASLL SLKGSRDLAA QGFTALCRSL NLKARLIFSL QPLTFSTASY
DDWSPHILPE ETSTSIDDDL RYPIFWTEIY DQSEKKWIAV DAVVLNGVYT NDMTWFEPKG
AYAESKHLRM GIVAAYDNDL YAKDVTLRYT DYQSSRLKKI RHVSFADKYF DFYKAIFGQL
AKRNKDAEDI YEEKELESKV PIREPKSFAD FKNHPEFVLI RHLRREEALL PNAKPVKTAT
FGNGKKATSE EVYLRKDVVI CKTPENYHKE GRVIKEGEQP RKMVKARAVT ISRKREHEFR
VAETNEPVLQ GLYSSDQTEL YVPPPIKDGI IPKNGYGNMD CFVESMIPKG AAHLPYRGIA
KIAKKLNIDY ADAVTGFEFR KHRAIPVTTG IIVPEESAQM VYEEFLECEK IRIEKQQMKE
RKIIYGQWKH LLNALRIRKR IEEQYA
