ID   RHRA_RHIME              Reviewed;         314 AA.
AC   Q9Z3Q6;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 116.
DE   RecName: Full=Transcriptional activator RhrA;
GN   Name=rhrA; OrderedLocusNames=RA1264; ORFNames=SMa2412;
OS   Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS   meliloti).
OG   Plasmid pSymA (megaplasmid 1).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=266834;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=RCR2011 / SU47;
RX   PubMed=11274118; DOI=10.1128/jb.183.8.2576-2585.2001;
RA   Lynch D., O'Brien J., Welch T., Clarke P., Cuiv P.O., Crosa J.H.,
RA   O'Connell M.;
RT   "Genetic organization of the region encoding regulation, biosynthesis, and
RT   transport of rhizobactin 1021, a siderophore produced by Sinorhizobium
RT   meliloti.";
RL   J. Bacteriol. 183:2576-2585(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=11481432; DOI=10.1073/pnas.161294798;
RA   Barnett M.J., Fisher R.F., Jones T., Komp C., Abola A.P., Barloy-Hubler F.,
RA   Bowser L., Capela D., Galibert F., Gouzy J., Gurjal M., Hong A., Huizar L.,
RA   Hyman R.W., Kahn D., Kahn M.L., Kalman S., Keating D.H., Palm C.,
RA   Peck M.C., Surzycki R., Wells D.H., Yeh K.-C., Davis R.W., Federspiel N.A.,
RA   Long S.R.;
RT   "Nucleotide sequence and predicted functions of the entire Sinorhizobium
RT   meliloti pSymA megaplasmid.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:9883-9888(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=11474104; DOI=10.1126/science.1060966;
RA   Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA   Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA   Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA   Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA   Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA   Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA   Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA   Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA   Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA   Wong K., Yeh K.-C., Batut J.;
RT   "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL   Science 293:668-672(2001).
CC   -!- FUNCTION: Transcriptional activator of the rhizobactin regulon.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF110737; AAD09418.1; -; Genomic_DNA.
DR   EMBL; AE006469; AAK65922.1; -; Genomic_DNA.
DR   PIR; H95419; H95419.
DR   PIR; T46820; T46820.
DR   RefSeq; NP_436510.1; NC_003037.1.
DR   RefSeq; WP_010968207.1; NC_003037.1.
DR   AlphaFoldDB; Q9Z3Q6; -.
DR   SMR; Q9Z3Q6; -.
DR   EnsemblBacteria; AAK65922; AAK65922; SMa2412.
DR   GeneID; 61599993; -.
DR   KEGG; sme:SMa2412; -.
DR   PATRIC; fig|266834.11.peg.1317; -.
DR   HOGENOM; CLU_049704_2_1_5; -.
DR   OMA; YFNRTFR; -.
DR   Proteomes; UP000001976; Plasmid pSymA.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR   Pfam; PF12833; HTH_18; 1.
DR   PRINTS; PR00032; HTHARAC.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   4: Predicted;
KW   Activator; DNA-binding; Ion transport; Iron; Iron transport; Plasmid;
KW   Reference proteome; Transcription; Transcription regulation; Transport.
FT   CHAIN           1..314
FT                   /note="Transcriptional activator RhrA"
FT                   /id="PRO_0000194575"
FT   DOMAIN          210..310
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        228..249
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        277..300
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ   SEQUENCE   314 AA;  34923 MW;  A384D16826DD9896 CRC64;
     METIRPLKFG TLSLPDRESR LVCRSILLDM LGEATIAPDE GDLTGVTGLF WKYVSLSLAT
     VYFPRTMLRV NASGMGDSGV VILRAMDSPL VIRHRRIKVE AARADVIFLP SDASSEITLP
     EGGRFDCAHL PAYALASKRD LLKPIMMQPL AAECLPLQLL TNYAGYLLRQ EYQSEEHAGM
     MVAHFYDLLP VLAQDIGNVS PRETPHNRMA SIKMRVEQNL ANGSFSITDV AEAERITPRA
     IQKFFSREGT TFSRYVLGRR LSLAKSLILA EGEATSISQI AYNVGFNDLS YFNRTFRSRY
     GVRPSDLRRL AAAA