RHSD_ECOLI
ID RHSD_ECOLI Reviewed; 1426 AA.
AC P16919; P77232; Q2MBT0;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-1998, sequence version 3.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Protein RhsD;
GN Name=rhsD; OrderedLocusNames=b0497, JW0486;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=1766878; DOI=10.1093/nar/19.25.7177;
RA Sadosky A.B., Gray J.A., Hill C.W.;
RT "The RhsD-E subfamily of Escherichia coli K-12.";
RL Nucleic Acids Res. 19:7177-7183(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RA Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT "Sequence of minutes 4-25 of Escherichia coli.";
RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-176.
RC STRAIN=EC45;
RA Wang Y.-D., Zhao S., Hill C.W.;
RL Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-100.
RC STRAIN=K12;
RX PubMed=2644231; DOI=10.1128/jb.171.2.636-642.1989;
RA Sadosky A.B., Davidson A., Lin R.J., Hill C.W.;
RT "rhs gene family of Escherichia coli K-12.";
RL J. Bacteriol. 171:636-642(1989).
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1232-1426.
RC STRAIN=K12;
RX PubMed=2403547; DOI=10.1128/jb.172.1.446-456.1990;
RA Feulner G., Gray J.A., Kirschman J.A., Lehner A.F., Sadosky A.B.,
RA Vlazny D.A., Zhang J., Zhao S., Hill C.W.;
RT "Structure of the rhsA locus from Escherichia coli K-12 and comparison of
RT rhsA with other members of the rhs multigene family.";
RL J. Bacteriol. 172:446-456(1990).
RN [8]
RP OPERON STRUCTURE, AND INDUCTION.
RC STRAIN=K12 / BW25113;
RX PubMed=19429622; DOI=10.1128/jb.00108-09;
RA Shimada T., Yamamoto K., Ishihama A.;
RT "Involvement of the leucine response transcription factor LeuO in
RT regulation of the genes for sulfa drug efflux.";
RL J. Bacteriol. 191:4562-4571(2009).
RN [9]
RP REVIEW.
RX PubMed=7934896; DOI=10.1111/j.1365-2958.1994.tb01074.x;
RA Hill C.W., Sandt C.H., Vlazny D.A.;
RT "Rhs elements of Escherichia coli: a family of genetic composites each
RT encoding a large mosaic protein.";
RL Mol. Microbiol. 12:865-871(1994).
CC -!- FUNCTION: Rhs elements have a nonessential function. They may play an
CC important role in the natural ecology of the cell.
CC -!- INDUCTION: Repressed by H-NS, induced by LeuO. Part of the rhsD-ybbC
CC operon. {ECO:0000269|PubMed:19429622}.
CC -!- DOMAIN: Each rhs appears to consist of a highly conserved 141 kDa amino
CC fragment followed by a highly divergent C-terminus.
CC -!- SIMILARITY: Belongs to the RHS family. {ECO:0000305}.
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DR EMBL; X60999; CAA43314.1; -; Genomic_DNA.
DR EMBL; U82664; AAB40251.1; -; Genomic_DNA.
DR EMBL; U00096; AAC73599.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE76276.1; -; Genomic_DNA.
DR EMBL; AF044500; AAC32467.1; -; Genomic_DNA.
DR PIR; H64780; H64780.
DR RefSeq; NP_415030.1; NC_000913.3.
DR RefSeq; WP_000014739.1; NZ_CP047127.1.
DR AlphaFoldDB; P16919; -.
DR SMR; P16919; -.
DR BioGRID; 4259865; 301.
DR DIP; DIP-10702N; -.
DR IntAct; P16919; 18.
DR STRING; 511145.b0497; -.
DR PaxDb; P16919; -.
DR PRIDE; P16919; -.
DR EnsemblBacteria; AAC73599; AAC73599; b0497.
DR EnsemblBacteria; BAE76276; BAE76276; BAE76276.
DR GeneID; 945116; -.
DR KEGG; ecj:JW0486; -.
DR KEGG; eco:b0497; -.
DR PATRIC; fig|1411691.4.peg.1779; -.
DR EchoBASE; EB0842; -.
DR eggNOG; COG3209; Bacteria.
DR HOGENOM; CLU_001218_0_1_6; -.
DR InParanoid; P16919; -.
DR OMA; LNYNRHR; -.
DR PhylomeDB; P16919; -.
DR BioCyc; EcoCyc:EG10849-MON; -.
DR PRO; PR:P16919; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0010438; P:cellular response to sulfur starvation; IEP:EcoCyc.
DR InterPro; IPR025479; DUF4329.
DR InterPro; IPR045351; DUF6531.
DR InterPro; IPR001826; RHS.
DR InterPro; IPR022385; Rhs_assc_core.
DR InterPro; IPR031325; RHS_repeat.
DR InterPro; IPR006530; YD.
DR Pfam; PF14220; DUF4329; 1.
DR Pfam; PF20148; DUF6531; 1.
DR Pfam; PF03527; RHS; 1.
DR Pfam; PF05593; RHS_repeat; 6.
DR PRINTS; PR00394; RHSPROTEIN.
DR TIGRFAMs; TIGR03696; Rhs_assc_core; 1.
DR TIGRFAMs; TIGR01643; YD_repeat_2x; 7.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat.
FT CHAIN 1..1426
FT /note="Protein RhsD"
FT /id="PRO_0000022228"
FT REPEAT 334..356
FT /note="1"
FT /evidence="ECO:0000305|PubMed:1766878"
FT REPEAT 357..378
FT /note="2"
FT /evidence="ECO:0000305|PubMed:1766878"
FT REPEAT 379..421
FT /note="3"
FT /evidence="ECO:0000305|PubMed:1766878"
FT REPEAT 422..442
FT /note="4"
FT /evidence="ECO:0000305|PubMed:1766878"
FT REPEAT 443..464
FT /note="5"
FT /evidence="ECO:0000305|PubMed:1766878"
FT REPEAT 465..485
FT /note="6"
FT /evidence="ECO:0000305|PubMed:1766878"
FT REPEAT 486..506
FT /note="7"
FT /evidence="ECO:0000305|PubMed:1766878"
FT REPEAT 507..529
FT /note="8"
FT /evidence="ECO:0000305|PubMed:1766878"
FT REPEAT 530..550
FT /note="9"
FT /evidence="ECO:0000305|PubMed:1766878"
FT REPEAT 551..571
FT /note="10"
FT /evidence="ECO:0000305|PubMed:1766878"
FT REPEAT 572..592
FT /note="11"
FT /evidence="ECO:0000305|PubMed:1766878"
FT REPEAT 593..613
FT /note="12"
FT /evidence="ECO:0000305|PubMed:1766878"
FT REPEAT 614..633
FT /note="13"
FT /evidence="ECO:0000305|PubMed:1766878"
FT REPEAT 634..654
FT /note="14"
FT /evidence="ECO:0000305|PubMed:1766878"
FT REPEAT 655..675
FT /note="15"
FT /evidence="ECO:0000305|PubMed:1766878"
FT REPEAT 676..695
FT /note="16"
FT /evidence="ECO:0000305|PubMed:1766878"
FT REPEAT 696..715
FT /note="17"
FT /evidence="ECO:0000305|PubMed:1766878"
FT REPEAT 716..738
FT /note="18"
FT /evidence="ECO:0000305|PubMed:1766878"
FT REPEAT 739..762
FT /note="19"
FT /evidence="ECO:0000305|PubMed:1766878"
FT REPEAT 812..832
FT /note="20"
FT /evidence="ECO:0000305|PubMed:1766878"
FT REPEAT 833..861
FT /note="21"
FT /evidence="ECO:0000305|PubMed:1766878"
FT REPEAT 862..882
FT /note="22"
FT /evidence="ECO:0000305|PubMed:1766878"
FT REPEAT 883..905
FT /note="23"
FT /evidence="ECO:0000305|PubMed:1766878"
FT REPEAT 906..941
FT /note="24"
FT /evidence="ECO:0000305|PubMed:1766878"
FT REPEAT 942..970
FT /note="25"
FT /evidence="ECO:0000305|PubMed:1766878"
FT REPEAT 971..995
FT /note="26"
FT /evidence="ECO:0000305|PubMed:1766878"
FT REPEAT 996..1030
FT /note="27"
FT /evidence="ECO:0000305|PubMed:1766878"
FT REPEAT 1173..1197
FT /note="28"
FT /evidence="ECO:0000305|PubMed:1766878"
FT REGION 256..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..1197
FT /note="28 X approximate tandem repeats"
FT /evidence="ECO:0000305|PubMed:1766878"
FT REGION 1073..1097
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..276
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1426 AA; 159725 MW; 122D697AA449BC2F CRC64;
MSGKPAARQG DMTQYGGPIV QGSAGVRIGA PTGVACSVCP GGMTSGNPVN PLLGAKVLPG
ETDLALPGPL PFILSRTYSS YRTKTPAPVG VFGPGWKAPS DIRLQLRDDG LILNDNGGRS
IHFEPLLPGE AVYSRSESMW LVRGGKAAQP DGHTLARLWG ALPPDIRLSP HLYLATNSAQ
GPWWILGWSE RVPGAEDVLP APLPPYRVLT GMADRFGRTL TYRREAAGDL AGEITGVTDG
AGREFRLVLT TQAQRAEEAR TSSLSSSDSS RPLSASAFPD TLPGTEYGPD RGIRLSAVWL
MHDPAYPESL PAAPLVRYTY TEAGELLAVY DRSNTQVRAF TYDAQHPGRM VAHRYAGRPE
MRYRYDDTGR VVEQLNPAGL SYRYLYEQDR ITVTDSLNRR EVLHTEGGAG LKRVVKKELA
DGSVTRSGYD AAGRLTAQTD AAGRRTEYGL NVVSGDITDI TTPDGRETKF YYNDGNQLTA
VVSPDGLESR REYDEPGRLV SETSRSGETV RYRYDDAHSE LPATTTDATG STRQMTWSRY
GQLLAFTDCS GYQTRYEYDR FGQMTAVHRE EGISLYRRYD NRGRLTSVKD AQGRETRYEY
NAAGDLTAVI TPDGNRSETQ YDAWGKAVST TQGGLTRSME YDAAGRVISL TNENGSHSVF
SYDALDRLVQ QGGFDGRTQR YHYDLTGKLT QSEDEGLVIL WYYDESDRIT HRTVNGEPAE
QWQYDGHGWL TDISHLSEGH RVAVHYGYDD KGRLTGECQT VENPETGELL WQHETKHAYN
EQGLANRVTP DSLPPVEWLT YGSGYLAGMK LGGTPLVEYT RDRLHRETVR SFGSMAGSNA
AYELTSTYTP AGQLQSQHLN SLVYDRDYGW SDNGDLVRIS GPRQTREYGY SATGRLESVR
TLAPDLDIRI PYATDPAGNR LPDPELHPDS TLTVWPDNRI AEDAHYVYRH DEYGRLTEKT
DRIPAGVIRT DDERTHHYHY DSQHRLVFYT RIQHGEPLVE SRYLYDPLGR RMAKRVWRRE
RDLTGWMSLS RKPEVTWYGW DGDRLTTVQT DTTRIQTVYE PGSFTPLIRV ETENGEREKA
QRRSLAETLQ QEGSENGHGV VFPAELVRLL DRLEEEIRAD RVSSESRAWL AQCGLTVEQL
ARQVEPEYTP ARKAHLYHCD HRGLPLALIS EDGNTAWSAE YDEWGNQLNE ENPHHVYQPY
RLPGQQHDEE SGLYYNRHRY YDPLQGRYIT QDPMGLKGGW NLYQYPLNPL QQIDPMGLLQ
TWDDARSGAC TGGVCGVLSR IIGPSKFDST ADAALDALKE TQNRSLCNDM EYSGIVCKDT
NGKYFASKAE TDNLRKESYP LKRKCPTGTD RVAAYHTHGA DSHGDYVDEF FSSSDKNLVR
SKDNNLEAFY LATPDGRFEA LNNKGEYIFI RNSVPGLSSV CIPYHD
