ID   RHSIA_DICD3             Reviewed;         135 AA.
AC   E0SAK7;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2010, sequence version 1.
DT   03-AUG-2022, entry version 41.
DE   RecName: Full=Immunity protein RhsIA;
GN   Name=rhsIA; OrderedLocusNames=Dda3937_01757;
OS   Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937)).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Dickeya.
OX   NCBI_TaxID=198628;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3937;
RX   PubMed=21217001; DOI=10.1128/jb.01513-10;
RA   Glasner J.D., Yang C.H., Reverchon S., Hugouvieux-Cotte-Pattat N.,
RA   Condemine G., Bohin J.P., Van Gijsegem F., Yang S., Franza T., Expert D.,
RA   Plunkett G. III, San Francisco M.J., Charkowski A.O., Py B., Bell K.,
RA   Rauscher L., Rodriguez-Palenzuela P., Toussaint A., Holeva M.C., He S.Y.,
RA   Douet V., Boccara M., Blanco C., Toth I., Anderson B.D., Biehl B.S.,
RA   Mau B., Flynn S.M., Barras F., Lindeberg M., Birch P.R., Tsuyumu S.,
RA   Shi X., Hibbing M., Yap M.N., Carpentier M., Dassa E., Umehara M.,
RA   Kim J.F., Rusch M., Soni P., Mayhew G.F., Fouts D.E., Gill S.R.,
RA   Blattner F.R., Keen N.T., Perna N.T.;
RT   "Genome sequence of the plant-pathogenic bacterium Dickeya dadantii 3937.";
RL   J. Bacteriol. 193:2076-2077(2011).
RN   [2]
RP   FUNCTION AS AN IMMUNITY PROTEIN, EXPRESSION IN E.COLI, AND DISRUPTION
RP   PHENOTYPE.
RC   STRAIN=3937;
RX   PubMed=23572593; DOI=10.1073/pnas.1300627110;
RA   Koskiniemi S., Lamoureux J.G., Nikolakakis K.C., t'Kint de Roodenbeke C.,
RA   Kaplan M.D., Low D.A., Hayes C.S.;
RT   "Rhs proteins from diverse bacteria mediate intercellular competition.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:7032-7037(2013).
CC   -!- FUNCTION: Immunity component of a toxin-immunity protein module, which
CC       functions as a cellular contact-dependent growth inhibition (CDI)
CC       system. Specifically inhibits its cognate toxin RhsA. Cell contact is
CC       necessary for growth inhibition. {ECO:0000269|PubMed:23572593}.
CC   -!- DISRUPTION PHENOTYPE: A double rhsA-rhsIA deletion is outcompeted by
CC       wild-type cells, restoration of rhsIA restores normal growth in
CC       competition experiments. Restoration of growth requires the RhsA-
CC       specific immunity protein, rhsIB does not restore growth.
CC       {ECO:0000269|PubMed:23572593}.
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DR   EMBL; CP002038; ADM97065.1; -; Genomic_DNA.
DR   RefSeq; WP_013316541.1; NC_014500.1.
DR   AlphaFoldDB; E0SAK7; -.
DR   SMR; E0SAK7; -.
DR   STRING; 198628.Dda3937_01757; -.
DR   PRIDE; E0SAK7; -.
DR   EnsemblBacteria; ADM97065; ADM97065; Dda3937_01757.
DR   GeneID; 9732266; -.
DR   KEGG; ddd:Dda3937_01757; -.
DR   eggNOG; ENOG5033I80; Bacteria.
DR   HOGENOM; CLU_146044_0_0_6; -.
DR   OMA; FRNEGMT; -.
DR   OrthoDB; 1485306at2; -.
DR   BioCyc; DDAD198628:DDA3937_RS04090-MON; -.
DR   Proteomes; UP000006859; Chromosome.
DR   InterPro; IPR028049; Imm-NTF2.
DR   Pfam; PF15655; Imm-NTF2; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..135
FT                   /note="Immunity protein RhsIA"
FT                   /id="PRO_0000423979"
FT   REGION          58..77
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   135 AA;  16447 MW;  B912A63306348748 CRC64;
     MTELSKAEKV LKEFIIQMNQ WELKYYPLFR NEGMTAYKDA AKKELDDIYD LFCTKKERKQ
     GRQISLSCGE PPEYSPDEEV LSSELNKNKC VFITQQYTEA KNKFRYTLQF KEDEWRIDKK
     ERFSFYDDKW IKYNL