ID   RHSIB_DICD3             Reviewed;         166 AA.
AC   E0SIS1;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2010, sequence version 1.
DT   03-AUG-2022, entry version 42.
DE   RecName: Full=Immunity protein RhsIB;
GN   Name=rhsIB; OrderedLocusNames=Dda3937_04645;
OS   Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937)).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Dickeya.
OX   NCBI_TaxID=198628;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3937;
RX   PubMed=21217001; DOI=10.1128/jb.01513-10;
RA   Glasner J.D., Yang C.H., Reverchon S., Hugouvieux-Cotte-Pattat N.,
RA   Condemine G., Bohin J.P., Van Gijsegem F., Yang S., Franza T., Expert D.,
RA   Plunkett G. III, San Francisco M.J., Charkowski A.O., Py B., Bell K.,
RA   Rauscher L., Rodriguez-Palenzuela P., Toussaint A., Holeva M.C., He S.Y.,
RA   Douet V., Boccara M., Blanco C., Toth I., Anderson B.D., Biehl B.S.,
RA   Mau B., Flynn S.M., Barras F., Lindeberg M., Birch P.R., Tsuyumu S.,
RA   Shi X., Hibbing M., Yap M.N., Carpentier M., Dassa E., Umehara M.,
RA   Kim J.F., Rusch M., Soni P., Mayhew G.F., Fouts D.E., Gill S.R.,
RA   Blattner F.R., Keen N.T., Perna N.T.;
RT   "Genome sequence of the plant-pathogenic bacterium Dickeya dadantii 3937.";
RL   J. Bacteriol. 193:2076-2077(2011).
RN   [2]
RP   FUNCTION AS AN IMMUNITY PROTEIN, AND DISRUPTION PHENOTYPE.
RC   STRAIN=3937;
RX   PubMed=23572593; DOI=10.1073/pnas.1300627110;
RA   Koskiniemi S., Lamoureux J.G., Nikolakakis K.C., t'Kint de Roodenbeke C.,
RA   Kaplan M.D., Low D.A., Hayes C.S.;
RT   "Rhs proteins from diverse bacteria mediate intercellular competition.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:7032-7037(2013).
CC   -!- FUNCTION: Immunity component of a toxin-immunity protein module, which
CC       functions as a cellular contact-dependent growth inhibition (CDI)
CC       system. Specifically inhibits its cognate toxin RhsB. Cell contact is
CC       necessary for growth inhibition. {ECO:0000269|PubMed:23572593}.
CC   -!- DISRUPTION PHENOTYPE: A double rhsB-rhsIB deletion is outcompeted by
CC       wild-type cells, restoration of rhsIB restores normal growth in
CC       competition experiments. Restoration of growth requires the RhsB-
CC       specific immunity protein, rhsIA does not restore growth.
CC       {ECO:0000269|PubMed:23572593}.
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DR   EMBL; CP002038; ADM99130.1; -; Genomic_DNA.
DR   RefSeq; WP_013318568.1; NC_014500.1.
DR   AlphaFoldDB; E0SIS1; -.
DR   STRING; 198628.Dda3937_04645; -.
DR   EnsemblBacteria; ADM99130; ADM99130; Dda3937_04645.
DR   GeneID; 30316673; -.
DR   KEGG; ddd:Dda3937_04645; -.
DR   eggNOG; ENOG5030880; Bacteria.
DR   HOGENOM; CLU_1600094_0_0_6; -.
DR   OMA; ECDFISF; -.
DR   OrthoDB; 1721593at2; -.
DR   BioCyc; DDAD198628:DDA3937_RS22335-MON; -.
DR   Proteomes; UP000006859; Chromosome.
DR   Gene3D; 3.40.1580.10; -; 1.
DR   InterPro; IPR018958; Knr4/Smi1-like_dom.
DR   InterPro; IPR037883; Knr4/Smi1-like_sf.
DR   Pfam; PF09346; SMI1_KNR4; 1.
DR   SUPFAM; SSF160631; SSF160631; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..166
FT                   /note="Immunity protein RhsIB"
FT                   /id="PRO_0000423980"
SQ   SEQUENCE   166 AA;  19307 MW;  2968B9E943C2E72A CRC64;
     MNIENAYDQL NAWINTSNGS YIDIGGERYS FSRLKTITKD ELSNFESDNN LKLPNDYKSF
     LINVGCVNIF VGEKTAGIEI IPPTDIRNFS KSVFYNFGDD LYPRLLLTTS IPKLGYFGGF
     WMESESKENY GIFYPDIPPE LWIEECDFIK FDDWLIKLVK YKSRKI