RHTA_SALTS
ID RHTA_SALTS Reviewed; 295 AA.
AC E1W9W8; P74867;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 1.
DT 03-AUG-2022, entry version 47.
DE RecName: Full=Threonine/homoserine exporter RhtA;
GN Name=rhtA; OrderedLocusNames=SL1344_0807;
OS Salmonella typhimurium (strain SL1344).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=216597;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SL1344;
RX PubMed=22538806; DOI=10.1073/pnas.1201061109;
RA Kroger C., Dillon S.C., Cameron A.D., Papenfort K., Sivasankaran S.K.,
RA Hokamp K., Chao Y., Sittka A., Hebrard M., Handler K., Colgan A.,
RA Leekitcharoenphon P., Langridge G.C., Lohan A.J., Loftus B., Lucchini S.,
RA Ussery D.W., Dorman C.J., Thomson N.R., Vogel J., Hinton J.C.;
RT "The transcriptional landscape and small RNAs of Salmonella enterica
RT serovar Typhimurium.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:E1277-E1286(2012).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 147-295.
RC STRAIN=SL1344;
RX PubMed=8930920; DOI=10.1046/j.1365-2958.1996.00120.x;
RA Valdivia R.H., Falkow S.;
RT "Bacterial genetics by flow cytometry: rapid isolation of Salmonella
RT typhimurium acid-inducible promoters by differential fluorescence
RT induction.";
RL Mol. Microbiol. 22:367-378(1996).
CC -!- FUNCTION: Involved in the efflux of threonine and homoserine.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC superfamily. 10 TMS drug/metabolite exporter (DME) (TC 2.A.7.3) family.
CC {ECO:0000305}.
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DR EMBL; FQ312003; CBW16905.1; -; Genomic_DNA.
DR EMBL; U62709; AAC44602.1; -; Genomic_DNA.
DR RefSeq; WP_001119554.1; NZ_QASL01000012.1.
DR AlphaFoldDB; E1W9W8; -.
DR SMR; E1W9W8; -.
DR EnsemblBacteria; CBW16905; CBW16905; SL1344_0807.
DR KEGG; sey:SL1344_0807; -.
DR PATRIC; fig|216597.6.peg.899; -.
DR HOGENOM; CLU_057295_0_1_6; -.
DR OMA; MWAAYIV; -.
DR BioCyc; SENT216597:SL1344_RS04210-MON; -.
DR Proteomes; UP000008962; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR InterPro; IPR000620; EamA_dom.
DR Pfam; PF00892; EamA; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Cell inner membrane; Cell membrane; Membrane; Repeat;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..295
FT /note="Threonine/homoserine exporter RhtA"
FT /id="PRO_0000405415"
FT TOPO_DOM 1..7
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..38
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..71
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 93
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..118
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 140..146
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..175
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 197..200
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 222..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..262
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 284..295
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 30..135
FT /note="EamA 1"
FT DOMAIN 159..278
FT /note="EamA 2"
FT CONFLICT 147..148
FT /note="LT -> IP (in Ref. 2; AAC44602)"
FT /evidence="ECO:0000305"
FT CONFLICT 234
FT /note="P -> A (in Ref. 2; AAC44602)"
FT /evidence="ECO:0000305"
FT CONFLICT 237
FT /note="T -> N (in Ref. 2; AAC44602)"
FT /evidence="ECO:0000305"
FT CONFLICT 288..295
FT /note="QIKQVDVK -> AN (in Ref. 2; AAC44602)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 295 AA; 31228 MW; 81FB4F2C3427637C CRC64;
MPGSTRKLPV WLPILVLLIA MSSIQSGASL AKSLFPLVGA PGVTALRLAL GTLILIAFFK
PWRLRFAKEQ RLPLLFYGLS LGGMNYLFYL SIQTVPLGIA VALEFTGPLA VALFSSRRPV
DFIWVVLAVL GLWFLLPLGQ DMSHVDLTGA ALALGAGACW AVYILTGQRA GAEHGPATVA
VGSLIAAIIF VPIGAVQAGD ALWHWSILPL GLAVAVLSTA LPYSLEMIAL TRLPTRTFGT
LMSMEPALAA VSGMIFLGET LTGIQILALC AIIAASMGST LTIRREPQIK QVDVK
