ID   RHTA_SALTY              Reviewed;         295 AA.
AC   P0CL04; P74867;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-MAR-2011, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Threonine/homoserine exporter RhtA;
GN   Name=rhtA; OrderedLocusNames=STM0832;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Involved in the efflux of threonine and homoserine.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC       superfamily. 10 TMS drug/metabolite exporter (DME) (TC 2.A.7.3) family.
CC       {ECO:0000305}.
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DR   EMBL; AE006468; AAL19768.1; -; Genomic_DNA.
DR   RefSeq; NP_459809.1; NC_003197.2.
DR   RefSeq; WP_001119554.1; NC_003197.2.
DR   AlphaFoldDB; P0CL04; -.
DR   SMR; P0CL04; -.
DR   STRING; 99287.STM0832; -.
DR   PaxDb; P0CL04; -.
DR   EnsemblBacteria; AAL19768; AAL19768; STM0832.
DR   GeneID; 1252351; -.
DR   KEGG; stm:STM0832; -.
DR   PATRIC; fig|99287.12.peg.867; -.
DR   HOGENOM; CLU_057295_0_1_6; -.
DR   OMA; MWAAYIV; -.
DR   PhylomeDB; P0CL04; -.
DR   BioCyc; SENT99287:STM0832-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0015565; F:threonine efflux transmembrane transporter activity; IBA:GO_Central.
DR   InterPro; IPR000620; EamA_dom.
DR   Pfam; PF00892; EamA; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW   Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..295
FT                   /note="Threonine/homoserine exporter RhtA"
FT                   /id="PRO_0000108165"
FT   TOPO_DOM        1..7
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        29..38
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        60..71
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        93
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        115..118
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        140..146
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        168..175
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        197..200
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        222..237
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        259..262
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        263..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        284..295
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          30..135
FT                   /note="EamA 1"
FT   DOMAIN          159..278
FT                   /note="EamA 2"
SQ   SEQUENCE   295 AA;  31228 MW;  81FB4F2C3427637C CRC64;
     MPGSTRKLPV WLPILVLLIA MSSIQSGASL AKSLFPLVGA PGVTALRLAL GTLILIAFFK
     PWRLRFAKEQ RLPLLFYGLS LGGMNYLFYL SIQTVPLGIA VALEFTGPLA VALFSSRRPV
     DFIWVVLAVL GLWFLLPLGQ DMSHVDLTGA ALALGAGACW AVYILTGQRA GAEHGPATVA
     VGSLIAAIIF VPIGAVQAGD ALWHWSILPL GLAVAVLSTA LPYSLEMIAL TRLPTRTFGT
     LMSMEPALAA VSGMIFLGET LTGIQILALC AIIAASMGST LTIRREPQIK QVDVK