RHTB_SALTI
ID RHTB_SALTI Reviewed; 206 AA.
AC Q8Z3B4;
DT 21-FEB-2002, integrated into UniProtKB/Swiss-Prot.
DT 21-FEB-2002, sequence version 1.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=Homoserine/homoserine lactone efflux protein;
GN Name=rhtB; OrderedLocusNames=STY3599, t3337;
OS Salmonella typhi.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90370;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT18;
RX PubMed=11677608; DOI=10.1038/35101607;
RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA Barrell B.G.;
RT "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT serovar Typhi CT18.";
RL Nature 413:848-852(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700931 / Ty2;
RX PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT CT18.";
RL J. Bacteriol. 185:2330-2337(2003).
CC -!- FUNCTION: Conducts the efflux of homoserine and homoserine lactone.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Rht family. {ECO:0000305}.
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DR EMBL; AL513382; CAD07932.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO70865.1; -; Genomic_DNA.
DR RefSeq; NP_457791.1; NC_003198.1.
DR RefSeq; WP_000142520.1; NZ_WSUR01000033.1.
DR AlphaFoldDB; Q8Z3B4; -.
DR STRING; 220341.16504477; -.
DR EnsemblBacteria; AAO70865; AAO70865; t3337.
DR KEGG; stt:t3337; -.
DR KEGG; sty:STY3599; -.
DR PATRIC; fig|220341.7.peg.3668; -.
DR eggNOG; COG1280; Bacteria.
DR HOGENOM; CLU_079569_2_1_6; -.
DR OMA; PQFINPH; -.
DR Proteomes; UP000000541; Chromosome.
DR Proteomes; UP000002670; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006865; P:amino acid transport; IEA:InterPro.
DR InterPro; IPR004778; Homoserine/Threonine_efflux.
DR InterPro; IPR001123; LeuE-type.
DR PANTHER; PTHR30086; PTHR30086; 1.
DR Pfam; PF01810; LysE; 1.
DR PIRSF; PIRSF006324; LeuE; 1.
DR TIGRFAMs; TIGR00949; 2A76; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..206
FT /note="Homoserine/homoserine lactone efflux protein"
FT /id="PRO_0000094733"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 206 AA; 22308 MW; 40940D3DC0A5CAF2 CRC64;
MTFEWWFAYL LTSTLLSLSP GSGAINTMTT SINHGYRGAA ASIAGLQTGL GIHIVLVGVG
LGTLFSRSLI AFEILKWAGA AYLIWLGIQQ WRAAGAIDLH TLAQTQSRGR LFKRAIFVNL
TNPKSIVFLA ALFPQFIMPQ QPQLAQYLIL GVTTIVVDMI VMTGYATLAQ RIAAWIKGPK
QMKALNKAFG SLFMLVGALL ASARHA
