RHTB_SALTY
ID RHTB_SALTY Reviewed; 206 AA.
AC Q9L6N6;
DT 21-FEB-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Homoserine/homoserine lactone efflux protein;
GN Name=rhtB; OrderedLocusNames=STM3960; ORFNames=STMD1.30;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Conducts the efflux of homoserine and homoserine lactone.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Rht family. {ECO:0000305}.
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DR EMBL; AF233324; AAF33432.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL22804.1; -; Genomic_DNA.
DR RefSeq; NP_462845.1; NC_003197.2.
DR RefSeq; WP_000142528.1; NC_003197.2.
DR AlphaFoldDB; Q9L6N6; -.
DR STRING; 99287.STM3960; -.
DR PaxDb; Q9L6N6; -.
DR EnsemblBacteria; AAL22804; AAL22804; STM3960.
DR GeneID; 1255486; -.
DR KEGG; stm:STM3960; -.
DR PATRIC; fig|99287.12.peg.4178; -.
DR HOGENOM; CLU_079569_2_1_6; -.
DR OMA; PQFINPH; -.
DR PhylomeDB; Q9L6N6; -.
DR BioCyc; SENT99287:STM3960-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015171; F:amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042970; F:homoserine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006865; P:amino acid transport; IBA:GO_Central.
DR GO; GO:0042968; P:homoserine transport; IBA:GO_Central.
DR InterPro; IPR004778; Homoserine/Threonine_efflux.
DR InterPro; IPR001123; LeuE-type.
DR PANTHER; PTHR30086; PTHR30086; 1.
DR Pfam; PF01810; LysE; 1.
DR PIRSF; PIRSF006324; LeuE; 1.
DR TIGRFAMs; TIGR00949; 2A76; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..206
FT /note="Homoserine/homoserine lactone efflux protein"
FT /id="PRO_0000094734"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 206 AA; 22322 MW; E089B357D30750F2 CRC64;
MTFEWWFAYL LTSTLLSLSP GSGAINTMTT SINHGYRGAV ASIAGLQTGL GIHIVLVGVG
LGTLFSRSLL AFEILKWAGA AYLIWLGIQQ WRAAGAIDLH TLAQTQSRGR LFKRAIFVNL
TNPKSIVFLA ALFPQFIMPQ QPQLAQYLIL GVTTIVVDMV VMTGYATLAQ RIAAWIKGPK
QMKALNKAFG SLFMLVGALL ASARHA
