RHX13_MOUSE
ID RHX13_MOUSE Reviewed; 232 AA.
AC F6YCR7; Q8C1Q7;
DT 09-DEC-2015, integrated into UniProtKB/Swiss-Prot.
DT 16-NOV-2011, sequence version 2.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Homeobox protein Rhox13 {ECO:0000305};
DE AltName: Full=Reproductive homeobox protein 13 {ECO:0000312|MGI:MGI:1920864};
GN Name=Rhox13 {ECO:0000312|MGI:MGI:1920864};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|Proteomes:UP000000589};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX PubMed=18675325; DOI=10.1016/j.gene.2008.06.031;
RA Geyer C.B., Eddy E.M.;
RT "Identification and characterization of Rhox13, a novel X-linked mouse
RT homeobox gene.";
RL Gene 423:194-200(2008).
RN [2] {ECO:0000312|EMBL:AL512346}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:AL512346};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 137-232.
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAC25170.1};
RC TISSUE=Testis {ECO:0000312|EMBL:BAC25170.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: Probable transcription factor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|RuleBase:RU000682,
CC ECO:0000269|PubMed:18675325}.
CC -!- DEVELOPMENTAL STAGE: In adult testis, expressed in differentiating
CC spermatagonia and preleptotene spermatocytes, but not during other
CC stages of spermatogenesis (at protein level). Detected in testis from
CC 13.5 days post coitum (dpc) onwards. Detected in ovary from 13.5 dpc,
CC but levels gradually decline and are undetectable by 3 days post partum
CC (dpp). {ECO:0000269|PubMed:18675325}.
CC -!- SIMILARITY: Belongs to the paired-like homeobox family. {ECO:0000305}.
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DR EMBL; AL512346; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK007253; BAC25170.1; -; mRNA.
DR CCDS; CCDS57754.1; -.
DR RefSeq; NP_001171931.1; NM_001185002.1.
DR AlphaFoldDB; F6YCR7; -.
DR SMR; F6YCR7; -.
DR STRING; 10090.ENSMUSP00000117271; -.
DR PaxDb; F6YCR7; -.
DR PRIDE; F6YCR7; -.
DR ProteomicsDB; 253282; -.
DR Antibodypedia; 29868; 137 antibodies from 25 providers.
DR Ensembl; ENSMUST00000152730; ENSMUSP00000117271; ENSMUSG00000050197.
DR GeneID; 73614; -.
DR KEGG; mmu:73614; -.
DR UCSC; uc009szo.2; mouse.
DR CTD; 73614; -.
DR MGI; MGI:1920864; Rhox13.
DR VEuPathDB; HostDB:ENSMUSG00000050197; -.
DR eggNOG; KOG0490; Eukaryota.
DR GeneTree; ENSGT00940000163385; -.
DR HOGENOM; CLU_1194575_0_0_1; -.
DR InParanoid; F6YCR7; -.
DR OMA; IRQMCKE; -.
DR OrthoDB; 1270742at2759; -.
DR PhylomeDB; F6YCR7; -.
DR BioGRID-ORCS; 73614; 3 hits in 71 CRISPR screens.
DR PRO; PR:F6YCR7; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; F6YCR7; protein.
DR Bgee; ENSMUSG00000050197; Expressed in seminiferous tubule of testis and 13 other tissues.
DR Genevisible; F6YCR7; MM.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0071300; P:cellular response to retinoic acid; IDA:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..232
FT /note="Homeobox protein Rhox13"
FT /id="PRO_0000435030"
FT DNA_BIND 148..207
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 45..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..104
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 137
FT /note="Y -> D (in Ref. 3; BAC25170)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 232 AA; 25316 MW; F7384C68FB4EE790 CRC64;
MAHGVPFDHN YYIVECKEET NAEAQAGAMA ATSTEEAPGA VEVAQAAVAS SHDSGGAIGC
ATVKESESDS ESESDSESES DSSDSSDESD DDSSTSDEDT SDPEEAAAPS VAAVAAAAAP
PTVPAAAAIQ IPGPYRYRPP RRHVRRRRRG PPFHFAQWQV EEMESLFEET QYPDLLTRGE
LARTLNVPEV KVKVWFTNRR AKQRKIERRE MLRNIPPGAE DFIFITDFEE PS
