ID   RI15A_CRIRI             Reviewed;          68 AA.
AC   A6MWT0;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   25-MAY-2022, entry version 12.
DE   RecName: Full=Riparin-1.5 amide {ECO:0000303|PubMed:18601958, ECO:0000312|EMBL:ABQ88315.1};
DE   Flags: Precursor;
OS   Crinia riparia (Streambank froglet) (Flinders Ranges froglet).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Myobatrachoidea; Myobatrachidae;
OC   Myobatrachinae; Crinia.
OX   NCBI_TaxID=446489;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:ABQ88315.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DISCUSSION OF SEQUENCE.
RC   TISSUE=Skin {ECO:0000312|EMBL:ABQ88315.1};
RX   PubMed=18601958; DOI=10.1016/j.regpep.2008.06.004;
RA   Jackway R.J., Pukala T.L., Maselli V.M., Musgrave I.F., Bowie J.H., Liu Y.,
RA   Surinya-Johnson K.H., Donnellan S.C., Doyle J.R., Llewellyn L.E.,
RA   Tyler M.J.;
RT   "Disulfide-containing peptides from the glandular skin secretions of
RT   froglets of the genus Crinia: structure, activity and evolutionary
RT   trends.";
RL   Regul. Pept. 151:80-87(2008).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000269|PubMed:18601958}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; EF550519; ABQ88315.1; -; mRNA.
DR   AlphaFoldDB; A6MWT0; -.
DR   SMR; A6MWT0; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Amidation; Amphibian defense peptide; Cleavage on pair of basic residues;
KW   Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255, ECO:0000303|PubMed:18601958"
FT   PROPEP          16..41
FT                   /evidence="ECO:0000269|PubMed:18601958"
FT                   /id="PRO_0000371730"
FT   PEPTIDE         42..53
FT                   /note="Riparin-1.5 amide"
FT                   /id="PRO_5000254173"
FT   PROPEP          57..68
FT                   /evidence="ECO:0000250|UniProtKB:A6MWS9"
FT                   /id="PRO_0000371731"
FT   MOD_RES         53
FT                   /note="Cysteine amide"
FT                   /evidence="ECO:0000255, ECO:0000305"
FT   DISULFID        47..53
FT                   /evidence="ECO:0000250|UniProtKB:A6MWS9"
SQ   SEQUENCE   68 AA;  7176 MW;  B9002EB88ED7655C CRC64;
     MKIIVVLAVL MLVSAQVCLV SAAEMGHSSD NELSSRDLVK RFFLPPCAHK GTCGKRSIES
     SEGANGGE