RIBC1_HUMAN
ID RIBC1_HUMAN Reviewed; 379 AA.
AC Q8N443; B4E297; E9PDU2; Q5H931; Q96A80;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=RIB43A-like with coiled-coils protein 1;
GN Name=RIBC1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Testis, and Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8N443; Q8N8Y2: ATP6V0D2; NbExp=3; IntAct=EBI-10265323, EBI-3923949;
CC Q8N443; Q96GS4: BORCS6; NbExp=3; IntAct=EBI-10265323, EBI-10193358;
CC Q8N443; P24863: CCNC; NbExp=5; IntAct=EBI-10265323, EBI-395261;
CC Q8N443; Q9Y6C2: EMILIN1; NbExp=3; IntAct=EBI-10265323, EBI-744586;
CC Q8N443; Q9Y6C2-2: EMILIN1; NbExp=6; IntAct=EBI-10265323, EBI-11748557;
CC Q8N443; Q08379: GOLGA2; NbExp=3; IntAct=EBI-10265323, EBI-618309;
CC Q8N443; Q86YR5-3: GPSM1; NbExp=3; IntAct=EBI-10265323, EBI-10261098;
CC Q8N443; O75031: HSF2BP; NbExp=3; IntAct=EBI-10265323, EBI-7116203;
CC Q8N443; P19012: KRT15; NbExp=3; IntAct=EBI-10265323, EBI-739566;
CC Q8N443; Q15323: KRT31; NbExp=6; IntAct=EBI-10265323, EBI-948001;
CC Q8N443; O76013-2: KRT36; NbExp=3; IntAct=EBI-10265323, EBI-11958506;
CC Q8N443; O95751: LDOC1; NbExp=3; IntAct=EBI-10265323, EBI-740738;
CC Q8N443; Q8IVT2: MISP; NbExp=3; IntAct=EBI-10265323, EBI-2555085;
CC Q8N443; Q13064: MKRN3; NbExp=3; IntAct=EBI-10265323, EBI-2340269;
CC Q8N443; Q15777: MPPED2; NbExp=3; IntAct=EBI-10265323, EBI-2350461;
CC Q8N443; O43482: OIP5; NbExp=3; IntAct=EBI-10265323, EBI-536879;
CC Q8N443; Q99471: PFDN5; NbExp=3; IntAct=EBI-10265323, EBI-357275;
CC Q8N443; Q6NUQ1: RINT1; NbExp=7; IntAct=EBI-10265323, EBI-726876;
CC Q8N443; Q8IYX1: TBC1D21; NbExp=3; IntAct=EBI-10265323, EBI-12018146;
CC Q8N443; Q8IYF3: TEX11; NbExp=3; IntAct=EBI-10265323, EBI-742397;
CC Q8N443; Q08117-2: TLE5; NbExp=3; IntAct=EBI-10265323, EBI-11741437;
CC Q8N443; Q96NM4-3: TOX2; NbExp=3; IntAct=EBI-10265323, EBI-12815137;
CC Q8N443; P36406: TRIM23; NbExp=3; IntAct=EBI-10265323, EBI-740098;
CC Q8N443; P14373: TRIM27; NbExp=3; IntAct=EBI-10265323, EBI-719493;
CC Q8N443; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-10265323, EBI-739895;
CC Q8N443; A5D8V6: VPS37C; NbExp=6; IntAct=EBI-10265323, EBI-2559305;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8N443-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N443-2; Sequence=VSP_021178, VSP_021179;
CC Name=3;
CC IsoId=Q8N443-3; Sequence=VSP_044834, VSP_044835;
CC -!- SIMILARITY: Belongs to the RIB43A family. {ECO:0000305}.
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DR EMBL; AK057345; BAB71438.1; -; mRNA.
DR EMBL; AK304179; BAG65059.1; -; mRNA.
DR EMBL; Z97054; CAI42648.1; -; Genomic_DNA.
DR EMBL; Z97054; CAI42649.1; -; Genomic_DNA.
DR EMBL; Z97054; CAI42650.1; -; Genomic_DNA.
DR EMBL; BC036767; AAH36767.1; -; mRNA.
DR CCDS; CCDS14353.1; -. [Q8N443-2]
DR CCDS; CCDS35299.1; -. [Q8N443-1]
DR CCDS; CCDS59168.1; -. [Q8N443-3]
DR RefSeq; NP_001026915.1; NM_001031745.4. [Q8N443-1]
DR RefSeq; NP_001253982.1; NM_001267053.3. [Q8N443-3]
DR RefSeq; NP_659405.1; NM_144968.3. [Q8N443-2]
DR RefSeq; XP_005262045.1; XM_005261988.3. [Q8N443-1]
DR AlphaFoldDB; Q8N443; -.
DR SMR; Q8N443; -.
DR BioGRID; 127705; 61.
DR IntAct; Q8N443; 41.
DR STRING; 9606.ENSP00000364476; -.
DR iPTMnet; Q8N443; -.
DR PhosphoSitePlus; Q8N443; -.
DR BioMuta; RIBC1; -.
DR DMDM; 74762522; -.
DR MassIVE; Q8N443; -.
DR MaxQB; Q8N443; -.
DR PaxDb; Q8N443; -.
DR PeptideAtlas; Q8N443; -.
DR PRIDE; Q8N443; -.
DR ProteomicsDB; 19746; -.
DR ProteomicsDB; 71881; -. [Q8N443-1]
DR ProteomicsDB; 71882; -. [Q8N443-2]
DR Antibodypedia; 12543; 56 antibodies from 15 providers.
DR DNASU; 158787; -.
DR Ensembl; ENST00000375327.6; ENSP00000364476.3; ENSG00000158423.17. [Q8N443-1]
DR Ensembl; ENST00000414955.6; ENSP00000401463.2; ENSG00000158423.17. [Q8N443-3]
DR Ensembl; ENST00000457095.5; ENSP00000402080.1; ENSG00000158423.17. [Q8N443-2]
DR GeneID; 158787; -.
DR KEGG; hsa:158787; -.
DR MANE-Select; ENST00000375327.6; ENSP00000364476.3; NM_001031745.5; NP_001026915.1.
DR UCSC; uc004dsj.3; human. [Q8N443-1]
DR CTD; 158787; -.
DR DisGeNET; 158787; -.
DR GeneCards; RIBC1; -.
DR HGNC; HGNC:26537; RIBC1.
DR HPA; ENSG00000158423; Tissue enhanced (fallopian tube, testis).
DR neXtProt; NX_Q8N443; -.
DR OpenTargets; ENSG00000158423; -.
DR PharmGKB; PA134903330; -.
DR VEuPathDB; HostDB:ENSG00000158423; -.
DR eggNOG; ENOG502QWST; Eukaryota.
DR GeneTree; ENSGT00390000010825; -.
DR HOGENOM; CLU_061822_0_0_1; -.
DR InParanoid; Q8N443; -.
DR OMA; KNRREFD; -.
DR PhylomeDB; Q8N443; -.
DR TreeFam; TF324120; -.
DR PathwayCommons; Q8N443; -.
DR SignaLink; Q8N443; -.
DR BioGRID-ORCS; 158787; 8 hits in 694 CRISPR screens.
DR ChiTaRS; RIBC1; human.
DR GenomeRNAi; 158787; -.
DR Pharos; Q8N443; Tdark.
DR PRO; PR:Q8N443; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q8N443; protein.
DR Bgee; ENSG00000158423; Expressed in right uterine tube and 101 other tissues.
DR ExpressionAtlas; Q8N443; baseline and differential.
DR Genevisible; Q8N443; HS.
DR InterPro; IPR008805; RIB43A.
DR PANTHER; PTHR14517; PTHR14517; 1.
DR Pfam; PF05914; RIB43A; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..379
FT /note="RIB43A-like with coiled-coils protein 1"
FT /id="PRO_0000254093"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 82..111
FT /evidence="ECO:0000255"
FT COILED 216..304
FT /evidence="ECO:0000255"
FT VAR_SEQ 67..181
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044834"
FT VAR_SEQ 182..192
FT /note="DALSNQLRLAM -> GKQPGPPDSET (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_021178"
FT VAR_SEQ 193..379
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_021179"
FT VAR_SEQ 354..379
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044835"
FT CONFLICT 66
FT /note="Y -> C (in Ref. 1; BAG65059)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 379 AA; 44015 MW; BAEF361A74D38EE9 CRC64;
MYNIKQSTDT KEAAAIEARR NREKERQNRF FNVRNRVMGV DVQALNNQVG DRKRREAAER
SKEAAYGTSQ VQYDVVVQML EKEEADRTRQ LAKKVQEFRE QKQQLKNGRE FSLWDPGQVW
KGLPTYLSYS NTYPGPASLQ YFSGEDLDRD TRLRMQQGQF RYNLERQQQE QQQAKVDENY
TDALSNQLRL AMDAQATHLA RLEESCRAAM MCAMANANKA QAAVQAGRQR CERQREQKAN
LAEIQHQSTS DLLTENPQVA QHPMAPYRVL PYCWKGMTPE QQAAIRKEQE VQRSKKQAHR
QAEKTLDTEW KSQTMSSAQA VLELEEQERE LCAVFQRGLG SFNQQLANEQ KAQQDYLNSV
IYTNQPTAQY HQQFNTSSR
