RIBC2_BOVIN
ID RIBC2_BOVIN Reviewed; 377 AA.
AC Q32LJ7; G1K180;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2019, sequence version 2.
DT 03-AUG-2022, entry version 68.
DE RecName: Full=RIB43A-like with coiled-coils protein 2 {ECO:0000250|UniProtKB:Q9H4K1};
GN Name=RIBC2 {ECO:0000250|UniProtKB:Q9H4K1};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford;
RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT "A whole-genome assembly of the domestic cow, Bos taurus.";
RL Genome Biol. 10:R42.01-R42.10(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0007744|PDB:7RRO}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.40 ANGSTROMS), FUNCTION, SUBCELLULAR
RP LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=34715025; DOI=10.1016/j.cell.2021.10.007;
RA Gui M., Farley H., Anujan P., Anderson J.R., Maxwell D.W., Whitchurch J.B.,
RA Botsch J.J., Qiu T., Meleppattu S., Singh S.K., Zhang Q., Thompson J.,
RA Lucas J.S., Bingle C.D., Norris D.P., Roy S., Brown A.;
RT "De novo identification of mammalian ciliary motility proteins using cryo-
RT EM.";
RL Cell 184:5791-5806.e19(2021).
CC -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC doublet microtubules (DMTs) in cilia axoneme, which is required for
CC motile cilia beating. {ECO:0000269|PubMed:34715025}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000269|PubMed:34715025}.
CC -!- TISSUE SPECIFICITY: Expressed in trachea multiciliated cells.
CC {ECO:0000269|PubMed:34715025}.
CC -!- SIMILARITY: Belongs to the RIB43A family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI09544.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; BC109543; AAI09544.1; ALT_INIT; mRNA.
DR RefSeq; NP_001033280.2; NM_001038191.2.
DR RefSeq; XP_015326930.1; XM_015471444.1.
DR PDB; 7RRO; EM; 3.40 A; O/P/Q/R/S=1-377.
DR PDBsum; 7RRO; -.
DR AlphaFoldDB; Q32LJ7; -.
DR SMR; Q32LJ7; -.
DR STRING; 9913.ENSBTAP00000004671; -.
DR PaxDb; Q32LJ7; -.
DR PRIDE; Q32LJ7; -.
DR Ensembl; ENSBTAT00000004671; ENSBTAP00000004671; ENSBTAG00000003594.
DR GeneID; 540723; -.
DR KEGG; bta:540723; -.
DR CTD; 26150; -.
DR VEuPathDB; HostDB:ENSBTAG00000003594; -.
DR VGNC; VGNC:33958; RIBC2.
DR eggNOG; ENOG502QWST; Eukaryota.
DR GeneTree; ENSGT00390000010825; -.
DR HOGENOM; CLU_061822_0_1_1; -.
DR InParanoid; Q32LJ7; -.
DR OMA; NYYRCRY; -.
DR OrthoDB; 1276305at2759; -.
DR TreeFam; TF324120; -.
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000003594; Expressed in spermatid and 35 other tissues.
DR GO; GO:0005879; C:axonemal microtubule; IDA:UniProtKB.
DR InterPro; IPR008805; RIB43A.
DR PANTHER; PTHR14517; PTHR14517; 1.
DR Pfam; PF05914; RIB43A; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell projection; Coiled coil; Cytoplasm; Cytoskeleton;
KW Reference proteome.
FT CHAIN 1..377
FT /note="RIB43A-like with coiled-coils protein 2"
FT /id="PRO_0000254097"
FT COILED 217..250
FT /evidence="ECO:0000255"
FT COILED 282..308
FT /evidence="ECO:0000255"
SQ SEQUENCE 377 AA; 44695 MW; 974FBC3F2A025825 CRC64;
MEVAQPKDLK EDFVLAKRRH AELVRQKRIF NARNRIIGGD TTAWDAQVCD QNIKAATEKA
RDEAFAAEMR QNDKIACLSE NRERRDRKNL CKAINDFQQS FQRPETRREF DLSDPLALKK
DRPARQSDYD ARNTISGMQK FMGEDLNFHL RKKFQEEQNR EWSLQQQKEQ MIGRENQKCA
EDLYLKTRLQ FDETAKHLQN LETATRKAVC ATVKEFNKNQ ALESAEKKIQ ERKQEQEDNL
AEISNMLRGD LLSENPQQAA SSFGPHRVVP DRWKGMSQEQ LEEIRLVQRQ QVQEKLRLQE
EERQRDMDWD RRRIQKARAT LLFEQQQQRL QRGLRRALDC SNLSLAREQL LQKKHMKELC
TNHATEDYFT QFNTGSR