位置:首页 > 蛋白库 > RIBM_STRDJ
RIBM_STRDJ
ID   RIBM_STRDJ              Reviewed;         213 AA.
AC   K4REQ6; Q2VCE9;
DT   28-MAR-2018, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Riboflavin/roseoflavin transporter RibM {ECO:0000305};
GN   Name=ribM {ECO:0000303|PubMed:17541777};
GN   ORFNames=BN159_7145 {ECO:0000312|EMBL:CCK31524.1};
OS   Streptomyces davaonensis (strain DSM 101723 / JCM 4913 / KCC S-0913 / 768).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1214101;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=DSM 101723 / JCM 4913 / KCC S-0913 / 768;
RX   PubMed=17541777; DOI=10.1007/s00203-007-0258-1;
RA   Grill S., Yamaguchi H., Wagner H., Zwahlen L., Kusch U., Mack M.;
RT   "Identification and characterization of two Streptomyces davawensis
RT   riboflavin biosynthesis gene clusters.";
RL   Arch. Microbiol. 188:377-387(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 101723 / JCM 4913 / KCC S-0913 / 768;
RX   PubMed=23043000; DOI=10.1128/jb.01592-12;
RA   Jankowitsch F., Schwarz J., Ruckert C., Gust B., Szczepanowski R., Blom J.,
RA   Pelzer S., Kalinowski J., Mack M.;
RT   "Genome sequence of the bacterium Streptomyces davawensis JCM 4913 and
RT   heterologous production of the unique antibiotic roseoflavin.";
RL   J. Bacteriol. 194:6818-6827(2012).
RN   [3]
RP   FUNCTION, SUBCELLULAR LOCATION, AND BIOTECHNOLOGY.
RX   PubMed=22136195; DOI=10.1186/1472-6750-11-119;
RA   Hemberger S., Pedrolli D.B., Stolz J., Vogl C., Lehmann M., Mack M.;
RT   "RibM from Streptomyces davawensis is a riboflavin/roseoflavin transporter
RT   and may be useful for the optimization of riboflavin production strains.";
RL   BMC Biotechnol. 11:119-119(2011).
RN   [4]
RP   FUNCTION.
RX   PubMed=28406895; DOI=10.1371/journal.pntd.0005513;
RA   Balcazar D.E., Vanrell M.C., Romano P.S., Pereira C.A., Goldbaum F.A.,
RA   Bonomi H.R., Carrillo C.;
RT   "The superfamily keeps growing: Identification in trypanosomatids of RibJ,
RT   the first riboflavin transporter family in protists.";
RL   PLoS Negl. Trop. Dis. 11:E0005513-E0005513(2017).
CC   -!- FUNCTION: Transports riboflavin and roseoflavin (PubMed:17541777,
CC       PubMed:22136195, PubMed:28406895). Can also transport FMN and FAD
CC       (PubMed:28406895). May confer roseoflavin resistance to S.davawensis,
CC       which naturally produces this antibiotic during stationary growth phase
CC       (PubMed:22136195). {ECO:0000269|PubMed:17541777,
CC       ECO:0000269|PubMed:22136195, ECO:0000269|PubMed:28406895}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22136195};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- BIOTECHNOLOGY: Introduction of ribM into a high performance B.subtilis
CC       riboflavin production strain may improve riboflavin production process.
CC       {ECO:0000269|PubMed:22136195}.
CC   -!- SIMILARITY: Belongs to the nicotinamide ribonucleoside (NR) uptake
CC       permease (TC 4.B.1) family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DQ248961; ABB90841.1; -; Genomic_DNA.
DR   EMBL; HE971709; CCK31524.1; -; Genomic_DNA.
DR   RefSeq; WP_015661853.1; NC_020504.1.
DR   AlphaFoldDB; K4REQ6; -.
DR   SMR; K4REQ6; -.
DR   STRING; 1214101.BN159_7145; -.
DR   EnsemblBacteria; CCK31524; CCK31524; BN159_7145.
DR   KEGG; sdv:BN159_7145; -.
DR   PATRIC; fig|1214101.3.peg.7237; -.
DR   eggNOG; COG3201; Bacteria.
DR   HOGENOM; CLU_076589_0_0_11; -.
DR   OMA; WPDAYIF; -.
DR   OrthoDB; 1301128at2; -.
DR   Proteomes; UP000008043; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0034257; F:nicotinamide riboside transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR006419; NMN_transpt_PnuC.
DR   PANTHER; PTHR36122; PTHR36122; 1.
DR   Pfam; PF04973; NMN_transporter; 1.
DR   TIGRFAMs; TIGR01528; NMN_trans_PnuC; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..213
FT                   /note="Riboflavin/roseoflavin transporter RibM"
FT                   /id="PRO_0000443722"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..129
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        171..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   213 AA;  23749 MW;  E83762FD7C4F0F12 CRC64;
     MNWLNSEAFV LFDQHIIWSD MVGNILGLIT LALGFRRSLW TWPVQFLSGL VLFGAFYGHL
     TGSAGKQAVV MAVALYGWYQ WNRGTDKAAD GKVSVRFATW AERGAMIAAA AVGTVAVALL
     FKAYPSLSWD PWPDAYIFVG TIVAMYAQAR GMVEFWFAWL LVDLVGVPLN FANGYAFSGF
     VYVIYGALVL WGMRDWWLRS RRDSRPVLEG APA
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024