RIBN_BRUA4
ID RIBN_BRUA4 Reviewed; 284 AA.
AC A6WUW2;
DT 20-JAN-2016, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 25-MAY-2022, entry version 66.
DE RecName: Full=Riboflavin transporter {ECO:0000303|PubMed:23935051};
GN Name=ribN {ECO:0000303|PubMed:23935051};
GN OrderedLocusNames=Oant_0035 {ECO:0000312|EMBL:ABS12766.1};
OS Brucella anthropi (strain ATCC 49188 / DSM 6882 / CCUG 24695 / JCM 21032 /
OS LMG 3331 / NBRC 15819 / NCTC 12168 / Alc 37) (Ochrobactrum anthropi).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX NCBI_TaxID=439375;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49188 / DSM 6882 / CCUG 24695 / JCM 21032 / LMG 3331 / NBRC
RC 15819 / NCTC 12168 / Alc 37;
RX PubMed=21685287; DOI=10.1128/jb.05335-11;
RA Chain P.S., Lang D.M., Comerci D.J., Malfatti S.A., Vergez L.M., Shin M.,
RA Ugalde R.A., Garcia E., Tolmasky M.E.;
RT "Genome of Ochrobactrum anthropi ATCC 49188 T, a versatile opportunistic
RT pathogen and symbiont of several eukaryotic hosts.";
RL J. Bacteriol. 193:4274-4275(2011).
RN [2]
RP FUNCTION AS A TRANSPORTER.
RC STRAIN=ATCC 49188 / DSM 6882 / CCUG 24695 / JCM 21032 / LMG 3331 / NBRC
RC 15819 / NCTC 12168 / Alc 37;
RX PubMed=23935051; DOI=10.1128/jb.00644-13;
RA Garcia Angulo V.A., Bonomi H.R., Posadas D.M., Serer M.I., Torres A.G.,
RA Zorreguieta A., Goldbaum F.A.;
RT "Identification and characterization of RibN, a novel family of riboflavin
RT transporters from Rhizobium leguminosarum and other Proteobacteria.";
RL J. Bacteriol. 195:4611-4619(2013).
CC -!- FUNCTION: Transports riboflavin into the cell.
CC {ECO:0000269|PubMed:23935051}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- INDUCTION: Negatively regulated by riboflavin, probably via an FMN
CC riboswitch. {ECO:0000250|UniProtKB:Q1MIM3,
CC ECO:0000305|PubMed:23935051}.
CC -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC superfamily. 10 TMS drug/metabolite exporter (DME) (TC 2.A.7.3) family.
CC {ECO:0000305}.
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DR EMBL; CP000758; ABS12766.1; -; Genomic_DNA.
DR RefSeq; WP_011982272.1; NC_009667.1.
DR AlphaFoldDB; A6WUW2; -.
DR SMR; A6WUW2; -.
DR STRING; 439375.Oant_0035; -.
DR TCDB; 2.A.7.3.55; the drug/metabolite transporter (dmt) superfamily.
DR EnsemblBacteria; ABS12766; ABS12766; Oant_0035.
DR KEGG; oan:Oant_0035; -.
DR PATRIC; fig|439375.7.peg.36; -.
DR eggNOG; COG0697; Bacteria.
DR HOGENOM; CLU_032828_0_0_5; -.
DR OMA; TMKLAFP; -.
DR OrthoDB; 1420919at2; -.
DR PhylomeDB; A6WUW2; -.
DR Proteomes; UP000002301; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR000620; EamA_dom.
DR Pfam; PF00892; EamA; 2.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..284
FT /note="Riboflavin transporter"
FT /id="PRO_0000435359"
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 2..129
FT /note="EamA 1"
FT /evidence="ECO:0000255"
FT DOMAIN 141..273
FT /note="EamA 2"
FT /evidence="ECO:0000255"
SQ SEQUENCE 284 AA; 30844 MW; 50AD25BBA90AB818 CRC64;
MVAACSAYAA VNVATQWAGT RTGIPSVIIA FWQYVIALVL TLPLLVRDGT RALRTSHFGL
HVMRVALAAA GVQVWIYALT HVPIWQVVAL SMTSPFFVIL CARLFLQEKV TPARLLTTFT
GFIGALIIIA PWSDSYTVYS LLPILAAALW AGYSVMTKYL TRFEKPASIS AYMLVLLTPI
NAALWLASGL SMSAITAPDV EIWSILIVIG AFTALAQYFQ TAAYSIADAV YLQPFDDLRL
PINVIFGWIV FAAAPSINFW PGAALIIGAS LYLMRQDSGT SRTA