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RIBN_BRUA4
ID   RIBN_BRUA4              Reviewed;         284 AA.
AC   A6WUW2;
DT   20-JAN-2016, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Riboflavin transporter {ECO:0000303|PubMed:23935051};
GN   Name=ribN {ECO:0000303|PubMed:23935051};
GN   OrderedLocusNames=Oant_0035 {ECO:0000312|EMBL:ABS12766.1};
OS   Brucella anthropi (strain ATCC 49188 / DSM 6882 / CCUG 24695 / JCM 21032 /
OS   LMG 3331 / NBRC 15819 / NCTC 12168 / Alc 37) (Ochrobactrum anthropi).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=439375;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49188 / DSM 6882 / CCUG 24695 / JCM 21032 / LMG 3331 / NBRC
RC   15819 / NCTC 12168 / Alc 37;
RX   PubMed=21685287; DOI=10.1128/jb.05335-11;
RA   Chain P.S., Lang D.M., Comerci D.J., Malfatti S.A., Vergez L.M., Shin M.,
RA   Ugalde R.A., Garcia E., Tolmasky M.E.;
RT   "Genome of Ochrobactrum anthropi ATCC 49188 T, a versatile opportunistic
RT   pathogen and symbiont of several eukaryotic hosts.";
RL   J. Bacteriol. 193:4274-4275(2011).
RN   [2]
RP   FUNCTION AS A TRANSPORTER.
RC   STRAIN=ATCC 49188 / DSM 6882 / CCUG 24695 / JCM 21032 / LMG 3331 / NBRC
RC   15819 / NCTC 12168 / Alc 37;
RX   PubMed=23935051; DOI=10.1128/jb.00644-13;
RA   Garcia Angulo V.A., Bonomi H.R., Posadas D.M., Serer M.I., Torres A.G.,
RA   Zorreguieta A., Goldbaum F.A.;
RT   "Identification and characterization of RibN, a novel family of riboflavin
RT   transporters from Rhizobium leguminosarum and other Proteobacteria.";
RL   J. Bacteriol. 195:4611-4619(2013).
CC   -!- FUNCTION: Transports riboflavin into the cell.
CC       {ECO:0000269|PubMed:23935051}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- INDUCTION: Negatively regulated by riboflavin, probably via an FMN
CC       riboswitch. {ECO:0000250|UniProtKB:Q1MIM3,
CC       ECO:0000305|PubMed:23935051}.
CC   -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC       superfamily. 10 TMS drug/metabolite exporter (DME) (TC 2.A.7.3) family.
CC       {ECO:0000305}.
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DR   EMBL; CP000758; ABS12766.1; -; Genomic_DNA.
DR   RefSeq; WP_011982272.1; NC_009667.1.
DR   AlphaFoldDB; A6WUW2; -.
DR   SMR; A6WUW2; -.
DR   STRING; 439375.Oant_0035; -.
DR   TCDB; 2.A.7.3.55; the drug/metabolite transporter (dmt) superfamily.
DR   EnsemblBacteria; ABS12766; ABS12766; Oant_0035.
DR   KEGG; oan:Oant_0035; -.
DR   PATRIC; fig|439375.7.peg.36; -.
DR   eggNOG; COG0697; Bacteria.
DR   HOGENOM; CLU_032828_0_0_5; -.
DR   OMA; TMKLAFP; -.
DR   OrthoDB; 1420919at2; -.
DR   PhylomeDB; A6WUW2; -.
DR   Proteomes; UP000002301; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000620; EamA_dom.
DR   Pfam; PF00892; EamA; 2.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..284
FT                   /note="Riboflavin transporter"
FT                   /id="PRO_0000435359"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          2..129
FT                   /note="EamA 1"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          141..273
FT                   /note="EamA 2"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   284 AA;  30844 MW;  50AD25BBA90AB818 CRC64;
     MVAACSAYAA VNVATQWAGT RTGIPSVIIA FWQYVIALVL TLPLLVRDGT RALRTSHFGL
     HVMRVALAAA GVQVWIYALT HVPIWQVVAL SMTSPFFVIL CARLFLQEKV TPARLLTTFT
     GFIGALIIIA PWSDSYTVYS LLPILAAALW AGYSVMTKYL TRFEKPASIS AYMLVLLTPI
     NAALWLASGL SMSAITAPDV EIWSILIVIG AFTALAQYFQ TAAYSIADAV YLQPFDDLRL
     PINVIFGWIV FAAAPSINFW PGAALIIGAS LYLMRQDSGT SRTA
 
 
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