ID   RIBN_VIBCH              Reviewed;         298 AA.
AC   Q9KKU0;
DT   20-JAN-2016, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Riboflavin transporter {ECO:0000303|PubMed:23935051};
GN   Name=ribN {ECO:0000303|PubMed:23935051};
GN   OrderedLocusNames=VC_A1010 {ECO:0000312|EMBL:AAF96906.1};
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
RN   [2]
RP   FUNCTION AS A TRANSPORTER.
RC   STRAIN=ATCC 25870 / Classical Inaba 569B / Serotype O1;
RX   PubMed=23935051; DOI=10.1128/jb.00644-13;
RA   Garcia Angulo V.A., Bonomi H.R., Posadas D.M., Serer M.I., Torres A.G.,
RA   Zorreguieta A., Goldbaum F.A.;
RT   "Identification and characterization of RibN, a novel family of riboflavin
RT   transporters from Rhizobium leguminosarum and other Proteobacteria.";
RL   J. Bacteriol. 195:4611-4619(2013).
CC   -!- FUNCTION: Transports riboflavin into the cell.
CC       {ECO:0000269|PubMed:23935051}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC       superfamily. 10 TMS drug/metabolite exporter (DME) (TC 2.A.7.3) family.
CC       {ECO:0000305}.
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DR   EMBL; AE003853; AAF96906.1; -; Genomic_DNA.
DR   PIR; G82389; G82389.
DR   RefSeq; NP_233394.1; NC_002506.1.
DR   AlphaFoldDB; Q9KKU0; -.
DR   SMR; Q9KKU0; -.
DR   STRING; 243277.VC_A1010; -.
DR   DNASU; 2612784; -.
DR   EnsemblBacteria; AAF96906; AAF96906; VC_A1010.
DR   KEGG; vch:VC_A1010; -.
DR   PATRIC; fig|243277.26.peg.3616; -.
DR   eggNOG; COG0697; Bacteria.
DR   HOGENOM; CLU_032828_0_0_6; -.
DR   OMA; NDAMGKW; -.
DR   BioCyc; VCHO:VCA1010-MON; -.
DR   Proteomes; UP000000584; Chromosome 2.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000620; EamA_dom.
DR   Pfam; PF00892; EamA; 2.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..298
FT                   /note="Riboflavin transporter"
FT                   /id="PRO_0000435360"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        258..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          10..144
FT                   /note="EamA 1"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          156..284
FT                   /note="EamA 2"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   298 AA;  32891 MW;  1024E5F3EF3E6AAD CRC64;
     MSIKHHPLQG ALWMLTAGLA FAIVNSVAQY ASIQFGLPST TVALVQYAIA IVVILPYLKT
     LGIRQSLRTQ QFGWHLLRVF LAVIGIQLWL WALAYPVPIW QGIALLMTSP LFATIGSGLW
     LREKVGMARW VATLTGFIGA MIILEPWADD FNLASLLPVG AAFFWASYSL MVKKLSSHDS
     PSTMVVYLLL LITPFNLLLA LPDWQMPNGQ TVWLLLIGAG VMTALAQWAI AKAYAVADAS
     FVQPFDHAKL PLNVLAGWLV FGWVPPGRLW LGAAIIVLSV AFITQWETKK SRRERNIA