RIC1_CAEEL
ID RIC1_CAEEL Reviewed; 1470 AA.
AC Q09417; O62341;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 2.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Guanine nucleotide exchange factor subunit R06F6.8 {ECO:0000305};
DE AltName: Full=Protein RIC1 homolog {ECO:0000250|UniProtKB:P40395};
GN ORFNames=R06F6.8;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Probable component of a guanine nucleotide exchange factor
CC (GEF) that may be required for efficient fusion of endosome-derived
CC vesicles with the Golgi. {ECO:0000250|UniProtKB:Q4ADV7}.
CC -!- SUBUNIT: Component of a guanine nucleotide exchange factor (GEF)
CC complex. {ECO:0000250|UniProtKB:Q4ADV7}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=b;
CC IsoId=Q09417-1; Sequence=Displayed;
CC Name=a;
CC IsoId=Q09417-2; Sequence=VSP_012311;
CC -!- SIMILARITY: Belongs to the RIC1 family. {ECO:0000305}.
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DR EMBL; Z46794; CAA86778.2; -; Genomic_DNA.
DR EMBL; Z46794; CAA86785.2; -; Genomic_DNA.
DR PIR; T23979; T23979.
DR PIR; T23986; T23986.
DR RefSeq; NP_496328.2; NM_063927.4. [Q09417-1]
DR RefSeq; NP_496329.2; NM_063928.6.
DR AlphaFoldDB; Q09417; -.
DR BioGRID; 39977; 15.
DR DIP; DIP-26765N; -.
DR IntAct; Q09417; 8.
DR MINT; Q09417; -.
DR STRING; 6239.R06F6.8b; -.
DR iPTMnet; Q09417; -.
DR EPD; Q09417; -.
DR PaxDb; Q09417; -.
DR PeptideAtlas; Q09417; -.
DR EnsemblMetazoa; R06F6.8a.1; R06F6.8a.1; WBGene00011071. [Q09417-2]
DR EnsemblMetazoa; R06F6.8b.1; R06F6.8b.1; WBGene00011071. [Q09417-1]
DR GeneID; 174664; -.
DR UCSC; R06F6.8b; c. elegans. [Q09417-1]
DR CTD; 174664; -.
DR WormBase; R06F6.8a; CE36946; WBGene00011071; -. [Q09417-2]
DR WormBase; R06F6.8b; CE36947; WBGene00011071; -. [Q09417-1]
DR eggNOG; KOG2006; Eukaryota.
DR GeneTree; ENSGT00390000002955; -.
DR InParanoid; Q09417; -.
DR OMA; MVYDRAM; -.
DR OrthoDB; 261419at2759; -.
DR PhylomeDB; Q09417; -.
DR Reactome; R-CEL-6811438; Intra-Golgi traffic.
DR Reactome; R-CEL-6811440; Retrograde transport at the Trans-Golgi-Network.
DR Reactome; R-CEL-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR PRO; PR:Q09417; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00011071; Expressed in adult organism and 4 other tissues.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; ISS:UniProtKB.
DR GO; GO:0032991; C:protein-containing complex; ISS:UniProtKB.
DR GO; GO:0034066; C:Ric1-Rgp1 guanyl-nucleotide exchange factor complex; ISS:UniProtKB.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
DR GO; GO:0031267; F:small GTPase binding; ISS:UniProtKB.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0042177; P:negative regulation of protein catabolic process; ISS:UniProtKB.
DR GO; GO:0043547; P:positive regulation of GTPase activity; ISS:UniProtKB.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; ISS:UniProtKB.
DR InterPro; IPR009771; Ribosome_control_1.
DR InterPro; IPR040096; Ric1.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR22746; PTHR22746; 1.
DR Pfam; PF07064; RIC1; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix; WD repeat.
FT CHAIN 1..1470
FT /note="Guanine nucleotide exchange factor subunit R06F6.8"
FT /id="PRO_0000051511"
FT TRANSMEM 1294..1314
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 20..58
FT /note="WD 1"
FT REPEAT 68..107
FT /note="WD 2"
FT REPEAT 472..512
FT /note="WD 3"
FT REGION 673..710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 975..1001
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1017..1045
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1238..1259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1385..1447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 981..1001
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1023..1041
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1385..1411
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1412..1426
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1430..1447
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 975..977
FT /note="FFR -> L (in isoform a)"
FT /evidence="ECO:0000305"
FT /id="VSP_012311"
SQ SEQUENCE 1470 AA; 163385 MW; 30C8A09F9FC0362A CRC64;
MFIPNDRPSV LQLPKHEKDS TAADIKSIVA NRDRRLIAVA TNDAIYIWLA NPQLLLCSVG
VIDANFKETR GELKEIYWKP DSTSIAVTTN QCKILIYNLD LRDDEQCYNF TDSADPYFQR
NSPELFIKGS RPTAHLHPTI IINLADIPTC CVPSRDEFLV CLQNGFTHHV TWTGEIIASL
SFRASSIPFS VDQLQSKSEN ITSKSTYIFD AVYAPLLGGF AIVLSDGQGA LLTSNDPNFA
PNAILGVWAP NMKDATCCDV NHKFLLILFG CKNGDVCAYN IDELNGSLVQ SFRVAPKVTN
GPDLTNRLGP VHRITALANG YGFGAIWSPL SGAHALPRLV AVFTSFGAQS FCNLEGVVEE
DQNDRYTAIE WGPEGFQLWL GTENELMMQP FVRSASCSSP AMEHCDRAVL MSDSQVLISA
ARDREAEACA PHSVWDHITV THEYLSSNWP LRYASTDRNY KHLVVAGDQG MAYCSLSNRR
WKIFGNETQE KNLLVTGGVF IWNDDVIGVV GVAADTDKSH LSFYPISQRL DSRYASVVDL
EHKSVMSVLR DDVCAVFDIS AQITLYKLTA HLETGRDAFT KVSTEIVTVI RINEIVPHPT
CIVSLQMTQL NLDVRGKLSP AFYSSIDTVL VNISGRLITL SVNEDGKLHQ PMVIASYVEK
MWHDRCQVSQ STQSQNQDLP WKNHRRNGSN VSIQSVSTST TSEPSSPMNQ SCSSHLSNAL
WIACGAKGIK VWMPLVPGKR NLATQEMTFI AKRIMLPFEL DIYPIVISAK DCLAMGVESQ
LQHVARASRN QGQMESITMY GLHRNSEVFV HHLLRQLLKR NLGVFALELA GACRSLPHFT
HALELLLHGV LEEEATSSEP IPDPLLPRCV AFIHEFPEFL KTVAHCARKT ELALWRTLFD
VTGSPNALFE ECLQLKQLEN AASFVIVLQN LETTEVSMDQ AARLVKEALE EKKWTIAKEM
VRFARSIGSE DIDAFFRTPP PSAKTSLSRR PTVSSPSADS STEFVINRFQ AGAAGGRLNK
VRHSQSTEQK DAPRKDSIGG SSKDKMALSW GLSGELSPQL ATNRLAAKMT SILEDHAWHL
LNNYWLLDLG FFWSELQFDL LGLLETRRKQ ISLSPKTTNE NCFLIEDFAL ALTRLHAQFS
WPYPLIGSQF VHQIEKKLGN IRVSQSTASL NGLLNDSLDN IKKPKARKLE RTVVDLNGAR
SRIRETDIEA SEEDVEIQEA VLERVRGSAV ELAPVIDRSP STSSSMNHHA PLAPPSPSSC
DSRSLAGDCY QNTDFLVGEK SSRGNLQSSH QLELLLSLFS QTATIDWIFL FCLLSRDERK
LRQEINVSMV RRAGEKSFAR VRFACSELSR WAVEKCCGYV ALLQAFDAHL AVVAEQAGCA
DLKFSPDNEN RKASQKTSAD DPKRGRRRAD SGSSKLNNSF SNPKLNGMNG GRRERSRSAD
RAHKSVKRYD DVVCAEDALE KANEEGCSIM
