ID   RIC2_ARATH              Reviewed;         111 AA.
AC   Q8GYU0; Q8VWR4; Q9FZJ8;
DT   26-JUN-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=CRIB domain-containing protein RIC2;
DE   AltName: Full=ROP-interactive CRIB motif-containing protein 2;
DE   AltName: Full=Target of ROP protein RIC2;
GN   Name=RIC2; Synonyms=ric1; OrderedLocusNames=At1g27380; ORFNames=F17L21.16;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Columbia;
RA   Bavlnka B., Zarsky V., Cvrckova F.;
RT   "Identification of Rop-interacting proteins from A. thaliana.";
RL   Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11910074; DOI=10.1126/science.1071006;
RA   Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA   Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA   Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA   Shinagawa A., Shinozaki K.;
RT   "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL   Science 296:141-145(2002).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Kim C.J., Chen H., Shinn P., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   FUNCTION, INTERACTION WITH ARAC11/ROP1, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=11752391; DOI=10.2307/3871538;
RA   Wu G., Gu Y., Li S., Yang Z.;
RT   "A genome-wide analysis of Arabidopsis Rop-interactive CRIB motif-
RT   containing proteins that act as Rop GTPase targets.";
RL   Plant Cell 13:2841-2856(2001).
RN   [7]
RP   SUBCELLULAR LOCATION.
RX   PubMed=21124849; DOI=10.1371/journal.pone.0015481;
RA   Oikawa A., Joshi H.J., Rennie E.A., Ebert B., Manisseri C.,
RA   Heazlewood J.L., Scheller H.V.;
RT   "An integrative approach to the identification of Arabidopsis and rice
RT   genes involved in xylan and secondary wall development.";
RL   PLoS ONE 5:E15481-E15481(2010).
CC   -!- FUNCTION: Functions as downstream effector of Rho-related GTP binding
CC       proteins of the 'Rho of Plants' (ROPs) family. Participates in the
CC       propagation of ROP GTPase signals in specific cellular responses. Is
CC       involved in pollen tube growth regulation through its interaction with
CC       ARAC11/ROP1. {ECO:0000269|PubMed:11752391}.
CC   -!- SUBUNIT: Interacts with ARAC11/ROP1. {ECO:0000269|PubMed:11752391}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:11752391,
CC       ECO:0000305|PubMed:21124849}; Peripheral membrane protein
CC       {ECO:0000305|PubMed:11752391, ECO:0000305|PubMed:21124849}.
CC   -!- TISSUE SPECIFICITY: Expressed in roots, leaves, stems, flowers,
CC       siliques and pollen. {ECO:0000269|PubMed:11752391}.
CC   -!- MISCELLANEOUS: Over-expression of RIC2 in tobacco germinating pollen
CC       reduces pollen tube elongation. {ECO:0000305|PubMed:11752391}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF99747.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=CAC83627.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AJ309372; CAC83627.1; ALT_INIT; mRNA.
DR   EMBL; AC004557; AAF99747.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE30818.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE30819.1; -; Genomic_DNA.
DR   EMBL; AK117390; BAC42059.1; -; mRNA.
DR   EMBL; BT024810; ABD60693.1; -; mRNA.
DR   PIR; C86399; C86399.
DR   RefSeq; NP_564281.2; NM_102500.3.
DR   RefSeq; NP_849713.1; NM_179382.1.
DR   AlphaFoldDB; Q8GYU0; -.
DR   BioGRID; 24862; 1.
DR   STRING; 3702.AT1G27380.1; -.
DR   PaxDb; Q8GYU0; -.
DR   PRIDE; Q8GYU0; -.
DR   ProteomicsDB; 236865; -.
DR   EnsemblPlants; AT1G27380.1; AT1G27380.1; AT1G27380.
DR   EnsemblPlants; AT1G27380.2; AT1G27380.2; AT1G27380.
DR   GeneID; 839627; -.
DR   Gramene; AT1G27380.1; AT1G27380.1; AT1G27380.
DR   Gramene; AT1G27380.2; AT1G27380.2; AT1G27380.
DR   KEGG; ath:AT1G27380; -.
DR   Araport; AT1G27380; -.
DR   TAIR; locus:2016009; AT1G27380.
DR   HOGENOM; CLU_114322_3_0_1; -.
DR   InParanoid; Q8GYU0; -.
DR   OMA; KSSHATR; -.
DR   PRO; PR:Q8GYU0; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q8GYU0; baseline and differential.
DR   Genevisible; Q8GYU0; AT.
DR   GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR   GO; GO:0009860; P:pollen tube growth; IMP:TAIR.
DR   GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR   InterPro; IPR000095; CRIB_dom.
DR   InterPro; IPR044509; RIC2/4.
DR   PANTHER; PTHR46931; PTHR46931; 1.
DR   Pfam; PF00786; PBD; 1.
DR   SMART; SM00285; PBD; 1.
DR   PROSITE; PS50108; CRIB; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Growth regulation; Membrane; Reference proteome.
FT   CHAIN           1..111
FT                   /note="CRIB domain-containing protein RIC2"
FT                   /id="PRO_0000422725"
FT   DOMAIN          71..84
FT                   /note="CRIB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00057"
SQ   SEQUENCE   111 AA;  12586 MW;  C1A804DBDCC45AC2 CRC64;
     MDRNGANMLD GRVESDAKGS FRKDYTKMEN NNNGANISDG IYRIIRSFKS FSHFFIRYEE
     ETKEREAEME IGFPTDVKHL SHIGVDGTMT TFDNTSSSFP FSGFHLTGTV V