ID   RIC8A_CHICK             Reviewed;         539 AA.
AC   Q5ZL77;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Synembryn-A;
DE   AltName: Full=Protein Ric-8A;
GN   Name=RIC8A; ORFNames=RCJMB04_7f5;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Guanine nucleotide exchange factor (GEF), which can activate
CC       some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and
CC       GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in
CC       regulation of microtubule pulling forces during mitotic movement of
CC       chromosomes by stimulating G(i)-alpha protein (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with some GDP-bound G alpha proteins. Does not
CC       interact with G-alpha proteins when they are in complex with subunits
CC       beta and gamma (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the synembryn family. {ECO:0000305}.
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DR   EMBL; AJ719857; CAG31516.1; -; mRNA.
DR   RefSeq; NP_001026345.1; NM_001031174.1.
DR   RefSeq; XP_015141685.1; XM_015286199.1.
DR   AlphaFoldDB; Q5ZL77; -.
DR   SMR; Q5ZL77; -.
DR   STRING; 9031.ENSGALP00000006648; -.
DR   PaxDb; Q5ZL77; -.
DR   Ensembl; ENSGALT00000006659; ENSGALP00000006648; ENSGALG00000004191.
DR   Ensembl; ENSGALT00000097762; ENSGALP00000071454; ENSGALG00000004191.
DR   GeneID; 422987; -.
DR   KEGG; gga:422987; -.
DR   CTD; 60626; -.
DR   VEuPathDB; HostDB:geneid_422987; -.
DR   eggNOG; KOG4464; Eukaryota.
DR   GeneTree; ENSGT00390000014700; -.
DR   HOGENOM; CLU_018602_1_0_1; -.
DR   InParanoid; Q5ZL77; -.
DR   OMA; NADPIFT; -.
DR   OrthoDB; 1110075at2759; -.
DR   PhylomeDB; Q5ZL77; -.
DR   PRO; PR:Q5ZL77; -.
DR   Proteomes; UP000000539; Chromosome 5.
DR   Bgee; ENSGALG00000004191; Expressed in brain and 13 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0001965; F:G-protein alpha-subunit binding; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR019318; Gua_nucleotide_exch_fac_Ric8.
DR   InterPro; IPR008376; Synembryn.
DR   PANTHER; PTHR12425; PTHR12425; 1.
DR   Pfam; PF10165; Ric8; 1.
DR   PRINTS; PR01802; SYNEMBRYN.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Guanine-nucleotide releasing factor; Membrane;
KW   Reference proteome.
FT   CHAIN           1..539
FT                   /note="Synembryn-A"
FT                   /id="PRO_0000235895"
FT   REGION          507..539
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        522..539
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   539 AA;  61504 MW;  C75F8DDC24DF3E98 CRC64;
     MELRTVVATV ESGEQDAVLK VLQIYNQEKS QCFTFDDEER EERKKMAQLL IKFLERELQP
     SCQVTCLESI RILSRDKYCL EPFTTEEGLK TLSRHAGIDY SEELIREVPD LEVILESLKC
     LCNIVFSSPR AQELTAEARL VVGLTKRIKL YNERSLPHEV KFFDLRLLFL LTALRVDIRQ
     QLAQELRGIS LMTDTLELTL GVKWMDPYEV ATEEGLLPPL PRQETERAME ILKVLFNITF
     DSSKREVDEE DAALYRHLGA LLRHCLMISA DGEDRTEEFH SHTVNLLGNL PLKCLDVLLT
     PKVRPGSLEY MGVNMDAVNI LLDFLERRLD RGHKLKESLT PVLNLLTESA RVHRQTRKFL
     KAKVLPPLRD VKNRPEVGNS LRNKLVRLMT HIDTDVKHCA AEFLFVLCKE SVSRFVKYTG
     YGNAAGLLAA RGLMAGGREE GEYSEDEDTD TEEYKEAKPN INPVTGRVEE KLPNPMEGMT
     EEQKEYEAMK LVNMFDKLSR EQVIQPMGIT PSGNLAPMEN AIRDMADERS SSDSDLGLD