ID   RIC8A_DANRE             Reviewed;         548 AA.
AC   Q642H7;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Synembryn-A;
DE   AltName: Full=Protein Ric-8A;
GN   Name=ric8a; ORFNames=zgc:92294;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Guanine nucleotide exchange factor (GEF), which can activate
CC       some, but not all, G-alpha proteins by exchanging bound GDP for free
CC       GTP. Involved in regulation of microtubule pulling forces during
CC       mitotic movement of chromosomes by stimulating G(i)-alpha protein (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with some GDP-bound G alpha proteins. Does not
CC       interact with G-alpha proteins when they are in complex with subunits
CC       beta and gamma (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the synembryn family. {ECO:0000305}.
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DR   EMBL; BC081640; AAH81640.1; -; mRNA.
DR   RefSeq; NP_001005588.1; NM_001005588.1.
DR   AlphaFoldDB; Q642H7; -.
DR   SMR; Q642H7; -.
DR   STRING; 7955.ENSDARP00000107651; -.
DR   PaxDb; Q642H7; -.
DR   GeneID; 449546; -.
DR   KEGG; dre:449546; -.
DR   CTD; 60626; -.
DR   ZFIN; ZDB-GENE-040927-18; ric8a.
DR   eggNOG; KOG4464; Eukaryota.
DR   InParanoid; Q642H7; -.
DR   PRO; PR:Q642H7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0001965; F:G-protein alpha-subunit binding; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR019318; Gua_nucleotide_exch_fac_Ric8.
DR   InterPro; IPR008376; Synembryn.
DR   PANTHER; PTHR12425; PTHR12425; 1.
DR   Pfam; PF10165; Ric8; 1.
DR   PRINTS; PR01802; SYNEMBRYN.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Guanine-nucleotide releasing factor; Membrane;
KW   Reference proteome.
FT   CHAIN           1..548
FT                   /note="Synembryn-A"
FT                   /id="PRO_0000235896"
FT   REGION          443..484
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          517..548
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        532..548
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   548 AA;  61996 MW;  3AD20F0223A15048 CRC64;
     MDLNAIIEKM ETGDQDAALT ALQTYNKEKS QCFSFTSGEE EDRERLGELV LSFLERDLQP
     SCQLACLETI RILSRDKKSL SPFATRHAMQ ILIRHAGLGQ GEGVTPEIPD LEVIVEALKC
     LCNIVFNSEA AQEAAADLQL MVGLAERLKQ CREPQWNHDV RFFDLRLTFL ITALRVDVRA
     QLAHELRGVS LLSEALDATF GLCWPDMYEV ARAGFDGCSE LPPLGRQETE RVMEILKILF
     NVTFDSNRRH VDEEEAATYR HLGAILRHCI MSSAEGEERT EEMHSHTVNL LGNLPLPCLD
     VLLMPKVQQG SIEYMGVNMD AVKVLVEFME KRLDRGNKLK ETLLPSLNLL TESARIHRET
     RKFLRNKVLP PLRDVKNRPE VGNALRNKLV RLMTHIDTDV KHCAAEFLFV LCKESVSRFI
     KYTGYGNAAG LLAARGLMRG GRDPGHYSED EDSDTEEYRE AKPHINPVTG RVEEEQPNPM
     EGMTDEQKEY EAMKLVNMFD KLSREQVIQP MKIGADGKMT SMEPHELHHL ASQQFGESNN
     SDSDSDTN