ID   RIC8A_XENLA             Reviewed;         539 AA.
AC   Q45TX8;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 2.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Synembryn-A;
DE   AltName: Full=Protein Ric-8A;
GN   Name=ric8a; Synonyms=syn;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Romo X., Pasten P., Martinez S., Montecino M., Hinrichs M.V., Olate J.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Guanine nucleotide exchange factor (GEF), which can activate
CC       some, but not all, G-alpha proteins by exchanging bound GDP for free
CC       GTP. Involved in regulation of microtubule pulling forces during
CC       mitotic movement of chromosomes by stimulating G(i)-alpha protein (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with some GDP-bound G alpha proteins. Does not
CC       interact with G-alpha proteins when they are in complex with subunits
CC       beta and gamma (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the synembryn family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAZ23806.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; DQ115398; AAZ23806.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001165673.1; NM_001172202.1.
DR   AlphaFoldDB; Q45TX8; -.
DR   SMR; Q45TX8; -.
DR   GeneID; 100337603; -.
DR   CTD; 100337603; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR019318; Gua_nucleotide_exch_fac_Ric8.
DR   InterPro; IPR008376; Synembryn.
DR   PANTHER; PTHR12425; PTHR12425; 1.
DR   Pfam; PF10165; Ric8; 1.
DR   PRINTS; PR01802; SYNEMBRYN.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Guanine-nucleotide releasing factor; Membrane;
KW   Reference proteome.
FT   CHAIN           1..539
FT                   /note="Synembryn-A"
FT                   /id="PRO_0000235897"
FT   REGION          506..539
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   539 AA;  61274 MW;  BD3525AD19369ADB CRC64;
     MDLGALLDEL ESGDQELVQK SLAEYNQENS QCFFFNAEQR EERKKLGELV ISFLNRDLQP
     SCQIACLETI RILSRDKYAL SPFTGRSAIQ TLAQYAGLDY SEEMEMPCIP DGESAVEALK
     GLCNIIYNSV EAQEVAKDLR LVCGLARRLK LYNETRSSHE SKFFDLRLLF LLTALSVDMR
     RQLAQELRGV SLLTDALEST LALKWSDIYE VVTDHLAPPL GKEETERVME ILKALFNITF
     DISRREVDEE EAALYRHLAA ILRHCLLRQS DGEDRTEEFH GHTVNLLVNL PLMCLDVLLT
     PKVEQGSVEY MGMNMDTVEV LLQFLHRRLD RGHKLREMLT PVLNLLTESS RVHRETRKFL
     RAKVLPPLRD VKNRPEVGNT LRNKLVRLMT HVDTDVKHCA AEFLFVLCKE NVSRFVKYTG
     YGNAAGLLAA RGLLAGGRGE GCYSEDDDTD TEEYREAKAN INPVTGRVEE KQPNPMDGMT
     EEQKEYEAMK LVNMFDKLSR EQIIQPMGVT SDGRLGPLDE AAQKMLQRQE SSDLDSDSD