ID   RIC8A_XENTR             Reviewed;         539 AA.
AC   Q6P4W7;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Synembryn-A;
DE   AltName: Full=Protein Ric-8A;
GN   Name=ric8a;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Guanine nucleotide exchange factor (GEF), which can activate
CC       some, but not all, G-alpha proteins by exchanging bound GDP for free
CC       GTP. Involved in regulation of microtubule pulling forces during
CC       mitotic movement of chromosomes by stimulating G(i)-alpha protein (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with some GDP-bound G alpha proteins. Does not
CC       interact with G-alpha proteins when they are in complex with subunits
CC       beta and gamma (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the synembryn family. {ECO:0000305}.
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DR   EMBL; BC063218; AAH63218.1; -; mRNA.
DR   RefSeq; NP_989159.1; NM_203828.1.
DR   AlphaFoldDB; Q6P4W7; -.
DR   SMR; Q6P4W7; -.
DR   STRING; 8364.ENSXETP00000006281; -.
DR   PaxDb; Q6P4W7; -.
DR   GeneID; 394766; -.
DR   KEGG; xtr:394766; -.
DR   CTD; 60626; -.
DR   Xenbase; XB-GENE-5745094; ric8a.
DR   eggNOG; KOG4464; Eukaryota.
DR   HOGENOM; CLU_018602_1_0_1; -.
DR   InParanoid; Q6P4W7; -.
DR   OMA; CWPDPLV; -.
DR   OrthoDB; 1110075at2759; -.
DR   TreeFam; TF314907; -.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0001965; F:G-protein alpha-subunit binding; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR019318; Gua_nucleotide_exch_fac_Ric8.
DR   InterPro; IPR008376; Synembryn.
DR   PANTHER; PTHR12425; PTHR12425; 1.
DR   Pfam; PF10165; Ric8; 1.
DR   PRINTS; PR01802; SYNEMBRYN.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Guanine-nucleotide releasing factor; Membrane;
KW   Reference proteome.
FT   CHAIN           1..539
FT                   /note="Synembryn-A"
FT                   /id="PRO_0000235898"
SQ   SEQUENCE   539 AA;  61452 MW;  B8D1138EB0D9E8D2 CRC64;
     MDPGTLLDKL ESGDQELVQK ALAEYNQENS QCFFFNAEQR EERKKLGELV IKFLNRDLQP
     SCQMACLETI RILSRDKHAL SPFTGRSAIQ TLAQYAGLDY SEEMEMPSIP DGESAVEALK
     GLCNIIYNSV EAQEVAKELR LVCGLARRLK LYNETRSSHE SKFFDLRLLF LLTALSVDMR
     KQLAQELRGV SLLTDALEST LALKWSDIYE VVTDRLAPPL GKEETERVME ILKTLFNITF
     DISRREVDEE DAALYRHLAA ILRHCLLRQC DGEDRTEEFH GHTVNLLVNL PLMCLDVLLT
     PKVEQGSVEY MGMNMDTVEV LIQFLDRRLD RGHKLRETLT PVLNLLTESS RVHRETRKFL
     RAKVLPPLRD VKNRPEVGNT LRNKLVRLMT HVDTDVKHCA AEFLFVLCKE NVSRFVKYTG
     YGNAAGLLAA RGLLAGGRGE GRYSEDEDTD TEEYREAKPN INPVTGRVEE KQPNPMDGMT
     EEQKEYEAMK LVNMFDKLSR EQIIQPMGVT SDGRLEPLDE AAQKMLQRQE SSDLESDSD