ID   RIC8B_DANRE             Reviewed;         536 AA.
AC   Q6DRJ9;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Synembryn-B;
DE   AltName: Full=Protein Ric-8B;
DE   AltName: Full=Synembryn-like;
GN   Name=ric8b; Synonyms=synbl;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15256591; DOI=10.1073/pnas.0403929101;
RA   Amsterdam A., Nissen R.M., Sun Z., Swindell E.C., Farrington S.,
RA   Hopkins N.;
RT   "Identification of 315 genes essential for early zebrafish development.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:12792-12797(2004).
CC   -!- FUNCTION: Guanine nucleotide exchange factor (GEF), which can activate
CC       some, but not all, G-alpha proteins by exchanging bound GDP for free
CC       GTP. {ECO:0000305}.
CC   -!- SUBUNIT: Interacts with some GDP-bound G alpha proteins. Does not
CC       interact with G-alpha proteins when they are in complex with subunits
CC       beta and gamma (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the synembryn family. {ECO:0000305}.
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DR   EMBL; AY648760; AAT68078.1; -; mRNA.
DR   RefSeq; NP_001005293.1; NM_001005293.1.
DR   AlphaFoldDB; Q6DRJ9; -.
DR   SMR; Q6DRJ9; -.
DR   STRING; 7955.ENSDARP00000012229; -.
DR   PaxDb; Q6DRJ9; -.
DR   PRIDE; Q6DRJ9; -.
DR   GeneID; 334503; -.
DR   KEGG; dre:334503; -.
DR   CTD; 55188; -.
DR   ZFIN; ZDB-GENE-030131-6435; ric8b.
DR   eggNOG; KOG4464; Eukaryota.
DR   InParanoid; Q6DRJ9; -.
DR   OrthoDB; 1110075at2759; -.
DR   PhylomeDB; Q6DRJ9; -.
DR   PRO; PR:Q6DRJ9; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001965; F:G-protein alpha-subunit binding; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0070285; P:pigment cell development; IMP:ZFIN.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR019318; Gua_nucleotide_exch_fac_Ric8.
DR   InterPro; IPR008376; Synembryn.
DR   PANTHER; PTHR12425; PTHR12425; 1.
DR   Pfam; PF10165; Ric8; 1.
DR   PRINTS; PR01802; SYNEMBRYN.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Guanine-nucleotide releasing factor; Reference proteome.
FT   CHAIN           1..536
FT                   /note="Synembryn-B"
FT                   /id="PRO_0000235902"
SQ   SEQUENCE   536 AA;  59522 MW;  5ACC9FA813572608 CRC64;
     MSLSDILSEI DGGDDKKVEK LLLKYNTENS RTFAFDLEEE GARIKLCQGL LTVLRRSDLP
     LCQSTCLETL RILSRDKHVL GPVATKEGML TLAGLARICV AGHEGEPLEE AQSAEEERVV
     VEALKCLCNV VFNSVPAQQM GGDLQLAEGL CPRLHLVSAS HHEVGLFSLR LLFLLSALRT
     DVRSTLQKEA GAVKLLTNVL ERTLDVRWVG PYEAAPPDPE APPIPPENNE LTMEALKALF
     NLTMSDSCDK DSLHKLRLIA GIMRHLLMLK THSEEKTEET HSHAINLLSN LPVQCLDVLI
     DVPVQGGLEK YRGKNMDTVQ ILLDFMIKRI DKGFNFKEGL TPVLSLLTES ARYHREIRRY
     IKAQILPPLK DVKERPEIGD TIRNKLVRLM THVDMAVKQG AAEFLFVLCK ESVDNLLKYT
     GYGNAAGLLM ARGLLAGGRG ETQYSSDEDS DTEEYKSVKP FINPITGHVE DPLPNPLDEM
     TEEQKEYEAQ RLVSMIDELS RKELIRPMGV RKDGTLAPLG QAIHDCSLAS SGSDSD