ID   RIC8_CAEBR              Reviewed;         567 AA.
AC   Q61A92; A8XJ50;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Synembryn;
DE   AltName: Full=Resistance to inhibitors of cholinesterase protein 8;
GN   Name=ric-8; ORFNames=CBG13878;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Guanine nucleotide exchange factor (GEF), which can activate
CC       some, but not all, G-alpha proteins independently of G-protein coupled
CC       receptors. Acts by exchanging bound GDP for free GTP. Also able to
CC       activate the G(s)-alpha in synaptic signaling network. Plays a key role
CC       in asymmetric spindle positioning, a step for asymmetric cell division
CC       that generates cell diversity during development by activating G(i)
CC       alpha protein goa-1 and gpa-16 independently of G-protein coupled
CC       receptors (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex {ECO:0000250}.
CC       Note=Localizes to the cell cortex. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the synembryn family. {ECO:0000305}.
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DR   EMBL; HE601467; CAP32675.3; -; Genomic_DNA.
DR   RefSeq; XP_002634779.1; XM_002634733.1.
DR   AlphaFoldDB; Q61A92; -.
DR   SMR; Q61A92; -.
DR   STRING; 6238.CBG13878; -.
DR   PRIDE; Q61A92; -.
DR   EnsemblMetazoa; CBG13878.1; CBG13878.1; WBGene00034564.
DR   GeneID; 8576771; -.
DR   KEGG; cbr:CBG_13878; -.
DR   CTD; 8576771; -.
DR   WormBase; CBG13878; CBP09517; WBGene00034564; Cbr-ric-8.
DR   eggNOG; KOG4464; Eukaryota.
DR   HOGENOM; CLU_018602_1_0_1; -.
DR   InParanoid; Q61A92; -.
DR   OMA; EDNHQFR; -.
DR   OrthoDB; 1110075at2759; -.
DR   Proteomes; UP000008549; Chromosome IV.
DR   GO; GO:0005818; C:aster; IEA:EnsemblMetazoa.
DR   GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005828; C:kinetochore microtubule; IEA:EnsemblMetazoa.
DR   GO; GO:0001965; F:G-protein alpha-subunit binding; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0090038; P:negative regulation of protein kinase C signaling; IEA:EnsemblMetazoa.
DR   GO; GO:0072697; P:protein localization to cell cortex; IEA:EnsemblMetazoa.
DR   GO; GO:2000114; P:regulation of establishment of cell polarity; IEA:EnsemblMetazoa.
DR   GO; GO:0060259; P:regulation of feeding behavior; IEA:EnsemblMetazoa.
DR   InterPro; IPR019318; Gua_nucleotide_exch_fac_Ric8.
DR   InterPro; IPR008376; Synembryn.
DR   PANTHER; PTHR12425; PTHR12425; 1.
DR   Pfam; PF10165; Ric8; 1.
DR   PRINTS; PR01802; SYNEMBRYN.
PE   3: Inferred from homology;
KW   Cytoplasm; Developmental protein; Guanine-nucleotide releasing factor;
KW   Reference proteome.
FT   CHAIN           1..567
FT                   /note="Synembryn"
FT                   /id="PRO_0000235903"
SQ   SEQUENCE   567 AA;  63621 MW;  16C2F55017F8140E CRC64;
     MPGDQLTEET IQRVFLNATS AKIEEFFSKW NFSNANSTKF GMSEAERNLL GDEISAKIDN
     DDLASILLET VRLISRERQG LESLLNENLC DTILKLAGIT PVVGYPRSVH ALMEAQKCLV
     NTMFHSAKMR ERFYMNLVNG DQIQRFLSEF EDSRRENSNI QWIREMNPTQ AAEVWYFYHR
     IAFIATAMDK GFQRHWADQS TTVSNILCAA EVCLQKASDD VANLDLLRAN EAMKTFFNVF
     CHFHGDVPGL DEKNTHLACR ILRDVICSGI PNDDVIQSAI HALSVPPLPM DLSVLLSDPN
     FPIVPLPETI SEEERVHPRD YYVNMTLTEA ILAALDKQLI KAVDLLNSVP FNQVSPEGNT
     LVDLSGPYFQ ALARLCVESK YARRYCRIRV LPPLVADEVK KRPEEHDSLR GRIVRVMMLP
     STTKEVASEF LFIICKRSVS RMIKYVGFGH SAGHLANFGL LGQINQPKHA SDSEDSETED
     YNAVKDNVNP VTGAMYPPDH GSAMDGMSDA QKEFEAMKLV DAMNKLMDQG LVKPGTIGDD
     GKVREVSHVL ELLKDAPEPD TMDSDSD