ID   RIHA_CITK8              Reviewed;         312 AA.
AC   A8AJF8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Pyrimidine-specific ribonucleoside hydrolase RihA {ECO:0000255|HAMAP-Rule:MF_01431};
DE            EC=3.2.-.- {ECO:0000255|HAMAP-Rule:MF_01431};
DE   AltName: Full=Cytidine/uridine-specific hydrolase {ECO:0000255|HAMAP-Rule:MF_01431};
GN   Name=rihA {ECO:0000255|HAMAP-Rule:MF_01431}; OrderedLocusNames=CKO_02512;
OS   Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Citrobacter.
OX   NCBI_TaxID=290338;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-895 / CDC 4225-83 / SGSC4696;
RG   The Citrobacter koseri Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S.,
RA   Latreille P., Courtney L., Wang C., Pepin K., Bhonagiri V., Nash W.,
RA   Johnson M., Thiruvilangam P., Wilson R.;
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Hydrolyzes cytidine or uridine to ribose and cytosine or
CC       uracil, respectively. {ECO:0000255|HAMAP-Rule:MF_01431}.
CC   -!- SIMILARITY: Belongs to the IUNH family. RihA subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01431}.
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DR   EMBL; CP000822; ABV13621.1; -; Genomic_DNA.
DR   RefSeq; WP_012133342.1; NC_009792.1.
DR   AlphaFoldDB; A8AJF8; -.
DR   SMR; A8AJF8; -.
DR   STRING; 290338.CKO_02512; -.
DR   EnsemblBacteria; ABV13621; ABV13621; CKO_02512.
DR   GeneID; 45136389; -.
DR   KEGG; cko:CKO_02512; -.
DR   HOGENOM; CLU_036838_2_0_6; -.
DR   OMA; VYFGPGF; -.
DR   OrthoDB; 1763387at2; -.
DR   Proteomes; UP000008148; Chromosome.
DR   GO; GO:0045437; F:uridine nucleosidase activity; IEA:InterPro.
DR   GO; GO:0015949; P:nucleobase-containing small molecule interconversion; IEA:InterPro.
DR   GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.90.245.10; -; 1.
DR   HAMAP; MF_01431; Pyrim_hydro_RihA; 1.
DR   InterPro; IPR015910; I/U_nuclsd_hydro_CS.
DR   InterPro; IPR001910; Inosine/uridine_hydrolase_dom.
DR   InterPro; IPR023186; IUNH.
DR   InterPro; IPR022975; Pyrim_hydro_RihA.
DR   InterPro; IPR036452; Ribo_hydro-like.
DR   PANTHER; PTHR12304; PTHR12304; 1.
DR   Pfam; PF01156; IU_nuc_hydro; 1.
DR   SUPFAM; SSF53590; SSF53590; 1.
DR   PROSITE; PS01247; IUNH; 1.
PE   3: Inferred from homology;
KW   Glycosidase; Hydrolase; Reference proteome.
FT   CHAIN           1..312
FT                   /note="Pyrimidine-specific ribonucleoside hydrolase RihA"
FT                   /id="PRO_1000024393"
FT   ACT_SITE        240
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01431"
SQ   SEQUENCE   312 AA;  33855 MW;  DAD9E11BD55B3D9A CRC64;
     MALPVLFDCD PGHDDAIAIV LALASPELDV KAITSSAGNQ TPDKTLRNVL RMLTLLGRND
     IPVAGGAIKP LMRDLIIADN VHGESGLDGP ALPEPSFAPQ TCTAVELMAK TLRESPEPVT
     IVATGPQTNV ALLLNSHPEL HRKIARIVIM GGAMGLGNWT PAAEFNIYVD PEAAEIVFQS
     GIPVVMAGLD VTHKAQIHAE DTERFRATGN PVSTIVAELL DFFLEYHKDE KWGFTGAPLH
     DPCTIAWLLK PELFTTVERW VGVETQGKYT QGMTVVDYYF LTGNKPNATV MVDIDRQGFV
     DLLAERLAFY AS