RIHA_ECO27
ID RIHA_ECO27 Reviewed; 311 AA.
AC B7UKT4;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 1.
DT 25-MAY-2022, entry version 64.
DE RecName: Full=Pyrimidine-specific ribonucleoside hydrolase RihA {ECO:0000255|HAMAP-Rule:MF_01431};
DE EC=3.2.-.- {ECO:0000255|HAMAP-Rule:MF_01431};
DE AltName: Full=Cytidine/uridine-specific hydrolase {ECO:0000255|HAMAP-Rule:MF_01431};
GN Name=rihA {ECO:0000255|HAMAP-Rule:MF_01431}; OrderedLocusNames=E2348C_0544;
OS Escherichia coli O127:H6 (strain E2348/69 / EPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=574521;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E2348/69 / EPEC;
RX PubMed=18952797; DOI=10.1128/jb.01238-08;
RA Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T., Henderson I.R.,
RA Harris D., Asadulghani M., Kurokawa K., Dean P., Kenny B., Quail M.A.,
RA Thurston S., Dougan G., Hayashi T., Parkhill J., Frankel G.;
RT "Complete genome sequence and comparative genome analysis of
RT enteropathogenic Escherichia coli O127:H6 strain E2348/69.";
RL J. Bacteriol. 191:347-354(2009).
CC -!- FUNCTION: Hydrolyzes with equal efficiency cytidine or uridine to
CC ribose and cytosine or uracil, respectively. {ECO:0000255|HAMAP-
CC Rule:MF_01431}.
CC -!- SIMILARITY: Belongs to the IUNH family. RihA subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01431}.
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DR EMBL; FM180568; CAS08092.1; -; Genomic_DNA.
DR RefSeq; WP_001207536.1; NC_011601.1.
DR AlphaFoldDB; B7UKT4; -.
DR SMR; B7UKT4; -.
DR EnsemblBacteria; CAS08092; CAS08092; E2348C_0544.
DR KEGG; ecg:E2348C_0544; -.
DR HOGENOM; CLU_036838_2_0_6; -.
DR OMA; HAPDIHG; -.
DR Proteomes; UP000008205; Chromosome.
DR GO; GO:0045437; F:uridine nucleosidase activity; IEA:InterPro.
DR GO; GO:0015949; P:nucleobase-containing small molecule interconversion; IEA:InterPro.
DR GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.90.245.10; -; 1.
DR HAMAP; MF_01431; Pyrim_hydro_RihA; 1.
DR InterPro; IPR015910; I/U_nuclsd_hydro_CS.
DR InterPro; IPR001910; Inosine/uridine_hydrolase_dom.
DR InterPro; IPR023186; IUNH.
DR InterPro; IPR022975; Pyrim_hydro_RihA.
DR InterPro; IPR036452; Ribo_hydro-like.
DR PANTHER; PTHR12304; PTHR12304; 1.
DR Pfam; PF01156; IU_nuc_hydro; 1.
DR SUPFAM; SSF53590; SSF53590; 1.
DR PROSITE; PS01247; IUNH; 1.
PE 3: Inferred from homology;
KW Glycosidase; Hydrolase.
FT CHAIN 1..311
FT /note="Pyrimidine-specific ribonucleoside hydrolase RihA"
FT /id="PRO_1000184892"
FT ACT_SITE 240
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01431"
SQ SEQUENCE 311 AA; 33880 MW; 31A2BDA68772E0CF CRC64;
MALPILLDCD PGHDDAIAIV LALASPELDV KAITSSAGNQ TPEKTLRNVL RMLTLLNRTD
IPVASGAVKP LMRNLIIADN VHGESGLDGP ALPEPAFAPQ NCTAVELMAK TLRESEEPVT
IVSTGPQTNV ALLLNSHPEL HSKIARIVIM GGAMGLGNWT PAAEFNIYVD PEAAEIVFQS
GIPVVMAGLD VTHKAQIHVE DTERFRAIGN PVSTIVAELL DFFLEYHKDE KWGFVGAPLH
DPCTIAWLLK PELFTTVERW VGVETQGKYT QGMTVVDYYY LTGNKPNATV MVDVDRQGFV
DLLADRLKFY A