RIHA_ECO7I
ID RIHA_ECO7I Reviewed; 311 AA.
AC B7NM03;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 1.
DT 25-MAY-2022, entry version 64.
DE RecName: Full=Pyrimidine-specific ribonucleoside hydrolase RihA {ECO:0000255|HAMAP-Rule:MF_01431};
DE EC=3.2.-.- {ECO:0000255|HAMAP-Rule:MF_01431};
DE AltName: Full=Cytidine/uridine-specific hydrolase {ECO:0000255|HAMAP-Rule:MF_01431};
GN Name=rihA {ECO:0000255|HAMAP-Rule:MF_01431};
GN OrderedLocusNames=ECIAI39_0619;
OS Escherichia coli O7:K1 (strain IAI39 / ExPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=585057;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAI39 / ExPEC;
RX PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H.,
RA Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E.,
RA Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C.,
RA Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S.,
RA Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J.,
RA Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT "Organised genome dynamics in the Escherichia coli species results in
RT highly diverse adaptive paths.";
RL PLoS Genet. 5:E1000344-E1000344(2009).
CC -!- FUNCTION: Hydrolyzes with equal efficiency cytidine or uridine to
CC ribose and cytosine or uracil, respectively. {ECO:0000255|HAMAP-
CC Rule:MF_01431}.
CC -!- SIMILARITY: Belongs to the IUNH family. RihA subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01431}.
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DR EMBL; CU928164; CAR16756.1; -; Genomic_DNA.
DR RefSeq; WP_001207533.1; NC_011750.1.
DR RefSeq; YP_002406645.1; NC_011750.1.
DR AlphaFoldDB; B7NM03; -.
DR SMR; B7NM03; -.
DR STRING; 585057.ECIAI39_0619; -.
DR EnsemblBacteria; CAR16756; CAR16756; ECIAI39_0619.
DR KEGG; ect:ECIAI39_0619; -.
DR PATRIC; fig|585057.6.peg.658; -.
DR HOGENOM; CLU_036838_2_0_6; -.
DR OMA; HAPDIHG; -.
DR Proteomes; UP000000749; Chromosome.
DR GO; GO:0045437; F:uridine nucleosidase activity; IEA:InterPro.
DR GO; GO:0015949; P:nucleobase-containing small molecule interconversion; IEA:InterPro.
DR GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.90.245.10; -; 1.
DR HAMAP; MF_01431; Pyrim_hydro_RihA; 1.
DR InterPro; IPR015910; I/U_nuclsd_hydro_CS.
DR InterPro; IPR001910; Inosine/uridine_hydrolase_dom.
DR InterPro; IPR023186; IUNH.
DR InterPro; IPR022975; Pyrim_hydro_RihA.
DR InterPro; IPR036452; Ribo_hydro-like.
DR PANTHER; PTHR12304; PTHR12304; 1.
DR Pfam; PF01156; IU_nuc_hydro; 1.
DR SUPFAM; SSF53590; SSF53590; 1.
DR PROSITE; PS01247; IUNH; 1.
PE 3: Inferred from homology;
KW Glycosidase; Hydrolase.
FT CHAIN 1..311
FT /note="Pyrimidine-specific ribonucleoside hydrolase RihA"
FT /id="PRO_1000145791"
FT ACT_SITE 240
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01431"
SQ SEQUENCE 311 AA; 33867 MW; C8711A26D661876F CRC64;
MALPILLDCD PGHDDAIAIV LALASPELDV KAITSSAGNQ TPEKTLRNVL RMLTLLNRTD
IPVASGAVKP LMRDLIIADN VHGESGLDGP ALPEPTFAPQ NCTAVELMAK TLRESAEPVT
IVSTGPQTNV ALLLNSHPEL HSKIARIVIM GGAMGLGNWT PAAEFNIYVD PEAAEIVFQS
GIPVVMAGLD VTHKAQIHVE DTERFRAIGN PVSTIVAELL DFFLEYHKDE KWGFVGAPLH
DPCTIAWLLK PELFTTVERW VGVETQGKYT QGMTVVDYYY LTGNKPNATV MVDVDRQGFV
DLLAERLKFY A