RIHA_ECOL5
ID RIHA_ECOL5 Reviewed; 311 AA.
AC Q0TK29;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Pyrimidine-specific ribonucleoside hydrolase RihA {ECO:0000255|HAMAP-Rule:MF_01431};
DE EC=3.2.-.- {ECO:0000255|HAMAP-Rule:MF_01431};
DE AltName: Full=Cytidine/uridine-specific hydrolase {ECO:0000255|HAMAP-Rule:MF_01431};
GN Name=rihA {ECO:0000255|HAMAP-Rule:MF_01431}; OrderedLocusNames=ECP_0674;
OS Escherichia coli O6:K15:H31 (strain 536 / UPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=362663;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=536 / UPEC;
RX PubMed=16879640; DOI=10.1111/j.1365-2958.2006.05255.x;
RA Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U.,
RA Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J.;
RT "Role of pathogenicity island-associated integrases in the genome
RT plasticity of uropathogenic Escherichia coli strain 536.";
RL Mol. Microbiol. 61:584-595(2006).
CC -!- FUNCTION: Hydrolyzes with equal efficiency cytidine or uridine to
CC ribose and cytosine or uracil, respectively. {ECO:0000255|HAMAP-
CC Rule:MF_01431}.
CC -!- SIMILARITY: Belongs to the IUNH family. RihA subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01431}.
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DR EMBL; CP000247; ABG68702.1; -; Genomic_DNA.
DR RefSeq; WP_001207538.1; NC_008253.1.
DR AlphaFoldDB; Q0TK29; -.
DR SMR; Q0TK29; -.
DR STRING; 362663.ECP_0674; -.
DR EnsemblBacteria; ABG68702; ABG68702; ECP_0674.
DR KEGG; ecp:ECP_0674; -.
DR HOGENOM; CLU_036838_2_0_6; -.
DR OMA; HAPDIHG; -.
DR Proteomes; UP000009182; Chromosome.
DR GO; GO:0045437; F:uridine nucleosidase activity; IEA:InterPro.
DR GO; GO:0015949; P:nucleobase-containing small molecule interconversion; IEA:InterPro.
DR GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.90.245.10; -; 1.
DR HAMAP; MF_01431; Pyrim_hydro_RihA; 1.
DR InterPro; IPR015910; I/U_nuclsd_hydro_CS.
DR InterPro; IPR001910; Inosine/uridine_hydrolase_dom.
DR InterPro; IPR023186; IUNH.
DR InterPro; IPR022975; Pyrim_hydro_RihA.
DR InterPro; IPR036452; Ribo_hydro-like.
DR PANTHER; PTHR12304; PTHR12304; 1.
DR Pfam; PF01156; IU_nuc_hydro; 1.
DR SUPFAM; SSF53590; SSF53590; 1.
DR PROSITE; PS01247; IUNH; 1.
PE 3: Inferred from homology;
KW Glycosidase; Hydrolase.
FT CHAIN 1..311
FT /note="Pyrimidine-specific ribonucleoside hydrolase RihA"
FT /id="PRO_1000024395"
FT ACT_SITE 240
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01431"
SQ SEQUENCE 311 AA; 33857 MW; C571679BBAD8DB2E CRC64;
MALPILLDCD PGHDDAIAIV LALASPELDV KAITSSAGNQ TPEKTLRNVL RMLTLLNRTD
IPVASGAVKP LMRNLIIADN VHGESGLDGP ALPEPTFAPQ NCTAVELMAK TLCESEEPVT
IVSTGPQTNV ALLLNSHPEL HSKIARIVIM GGAMGLGNWT PAAEFNIYVD PEAAEIVFQS
GIPVVMAGLD VTHKAQIHVE DTERFRAIGN PVSTIVAELL DFFLEYHKDE KWGFVGAPLH
DPCTIAWLLK PELFTTVERW VGVETQGKYT QGMTVVDYYY LTGNKPNATV MVDVDRQGFV
DLLADRLKFY A