RIHA_ECOL6
ID RIHA_ECOL6 Reviewed; 311 AA.
AC Q8FJY8;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 2.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Pyrimidine-specific ribonucleoside hydrolase RihA {ECO:0000255|HAMAP-Rule:MF_01431};
DE EC=3.2.-.- {ECO:0000255|HAMAP-Rule:MF_01431};
DE AltName: Full=Cytidine/uridine-specific hydrolase {ECO:0000255|HAMAP-Rule:MF_01431};
GN Name=rihA {ECO:0000255|HAMAP-Rule:MF_01431}; OrderedLocusNames=c0735;
OS Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=199310;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CFT073 / ATCC 700928 / UPEC;
RX PubMed=12471157; DOI=10.1073/pnas.252529799;
RA Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA Donnenberg M.S., Blattner F.R.;
RT "Extensive mosaic structure revealed by the complete genome sequence of
RT uropathogenic Escherichia coli.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC -!- FUNCTION: Hydrolyzes with equal efficiency cytidine or uridine to
CC ribose and cytosine or uracil, respectively. {ECO:0000255|HAMAP-
CC Rule:MF_01431}.
CC -!- SIMILARITY: Belongs to the IUNH family. RihA subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01431}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAN79208.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE014075; AAN79208.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_001207539.1; NC_004431.1.
DR AlphaFoldDB; Q8FJY8; -.
DR SMR; Q8FJY8; -.
DR STRING; 199310.c0735; -.
DR EnsemblBacteria; AAN79208; AAN79208; c0735.
DR KEGG; ecc:c0735; -.
DR eggNOG; COG1957; Bacteria.
DR HOGENOM; CLU_036838_2_0_6; -.
DR OMA; HAPDIHG; -.
DR Proteomes; UP000001410; Chromosome.
DR GO; GO:0045437; F:uridine nucleosidase activity; IEA:InterPro.
DR GO; GO:0015949; P:nucleobase-containing small molecule interconversion; IEA:InterPro.
DR GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.90.245.10; -; 1.
DR HAMAP; MF_01431; Pyrim_hydro_RihA; 1.
DR InterPro; IPR015910; I/U_nuclsd_hydro_CS.
DR InterPro; IPR001910; Inosine/uridine_hydrolase_dom.
DR InterPro; IPR023186; IUNH.
DR InterPro; IPR022975; Pyrim_hydro_RihA.
DR InterPro; IPR036452; Ribo_hydro-like.
DR PANTHER; PTHR12304; PTHR12304; 1.
DR Pfam; PF01156; IU_nuc_hydro; 1.
DR SUPFAM; SSF53590; SSF53590; 1.
DR PROSITE; PS01247; IUNH; 1.
PE 3: Inferred from homology;
KW Glycosidase; Hydrolase.
FT CHAIN 1..311
FT /note="Pyrimidine-specific ribonucleoside hydrolase RihA"
FT /id="PRO_0000206815"
FT ACT_SITE 240
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01431"
SQ SEQUENCE 311 AA; 33910 MW; 39147287DFCDC191 CRC64;
MALPILLDCD PGHDDAIAIV LALASPELDV KAITSSAGNQ TPEKTLRNVL RMLTLLNRTD
IPVASGAVKP LMRNLIIADN VHGESGLDGP ALPEPTFAPQ NCTAVELMAK TLRESEEPVT
IVSTGPQTNV ALLLNSHPEL HSKIARIVIM GGAMGLGNWT PAAEFNIYVD PEAAEIVFQS
GIPVVMAGLD VTHKAQIHVE DTERFRAIGN PVSTIVAELL DFFLEYHKDE KWGFVGAPLH
DPCTIAWLLK PELFTTVERW VGVETQGKYT QGMTVVDYYY LTGNKPNATV MVDVDRQGFV
DLLADRLKFY A