ID   RIHA_ECOSE              Reviewed;         311 AA.
AC   B6I163;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Pyrimidine-specific ribonucleoside hydrolase RihA {ECO:0000255|HAMAP-Rule:MF_01431};
DE            EC=3.2.-.- {ECO:0000255|HAMAP-Rule:MF_01431};
DE   AltName: Full=Cytidine/uridine-specific hydrolase {ECO:0000255|HAMAP-Rule:MF_01431};
GN   Name=rihA {ECO:0000255|HAMAP-Rule:MF_01431}; OrderedLocusNames=ECSE_0721;
OS   Escherichia coli (strain SE11).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=409438;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SE11;
RX   PubMed=18931093; DOI=10.1093/dnares/dsn026;
RA   Oshima K., Toh H., Ogura Y., Sasamoto H., Morita H., Park S.-H., Ooka T.,
RA   Iyoda S., Taylor T.D., Hayashi T., Itoh K., Hattori M.;
RT   "Complete genome sequence and comparative analysis of the wild-type
RT   commensal Escherichia coli strain SE11 isolated from a healthy adult.";
RL   DNA Res. 15:375-386(2008).
CC   -!- FUNCTION: Hydrolyzes with equal efficiency cytidine or uridine to
CC       ribose and cytosine or uracil, respectively. {ECO:0000255|HAMAP-
CC       Rule:MF_01431}.
CC   -!- SIMILARITY: Belongs to the IUNH family. RihA subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01431}.
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DR   EMBL; AP009240; BAG76245.1; -; Genomic_DNA.
DR   RefSeq; WP_001207503.1; NC_011415.1.
DR   AlphaFoldDB; B6I163; -.
DR   SMR; B6I163; -.
DR   EnsemblBacteria; BAG76245; BAG76245; ECSE_0721.
DR   KEGG; ecy:ECSE_0721; -.
DR   HOGENOM; CLU_036838_2_0_6; -.
DR   OMA; HAPDIHG; -.
DR   Proteomes; UP000008199; Chromosome.
DR   GO; GO:0045437; F:uridine nucleosidase activity; IEA:InterPro.
DR   GO; GO:0015949; P:nucleobase-containing small molecule interconversion; IEA:InterPro.
DR   GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.90.245.10; -; 1.
DR   HAMAP; MF_01431; Pyrim_hydro_RihA; 1.
DR   InterPro; IPR015910; I/U_nuclsd_hydro_CS.
DR   InterPro; IPR001910; Inosine/uridine_hydrolase_dom.
DR   InterPro; IPR023186; IUNH.
DR   InterPro; IPR022975; Pyrim_hydro_RihA.
DR   InterPro; IPR036452; Ribo_hydro-like.
DR   PANTHER; PTHR12304; PTHR12304; 1.
DR   Pfam; PF01156; IU_nuc_hydro; 1.
DR   SUPFAM; SSF53590; SSF53590; 1.
DR   PROSITE; PS01247; IUNH; 1.
PE   3: Inferred from homology;
KW   Glycosidase; Hydrolase.
FT   CHAIN           1..311
FT                   /note="Pyrimidine-specific ribonucleoside hydrolase RihA"
FT                   /id="PRO_1000145794"
FT   ACT_SITE        240
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01431"
SQ   SEQUENCE   311 AA;  33807 MW;  910007AA38059C8F CRC64;
     MALPILLDCD PGHDDAIAIV LALASPELDV KAITSSAGNQ TPEKTLRNVL RMLTLLNRTD
     IPVAGGAVKP LMRELIIADN VHGESGLDGP ALPEPAFAPQ NCTAVELMAK TLRESAEPVT
     IVSTGPQTNV ALLLNSHPEL HSKIARIVIM GGAMGLGNWT PAAEFNIYVD PEAAEIVFQS
     GIPVVMAGLD VTHKAQIHVE DTERFRAIGN PVSTIVAELL DFFLEYHKDE KWGFVGAPLH
     DPCTIAWLLK PELFTTVERW VGVETQGKYT QGMTVVDYYY LTGNKPNATV MVDVDRQGFV
     DLLADRLKFY A