ID   RIHA_PHOPR              Reviewed;         310 AA.
AC   Q6LQG2;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Pyrimidine-specific ribonucleoside hydrolase RihA {ECO:0000255|HAMAP-Rule:MF_01431};
DE            EC=3.2.-.- {ECO:0000255|HAMAP-Rule:MF_01431};
DE   AltName: Full=Cytidine/uridine-specific hydrolase {ECO:0000255|HAMAP-Rule:MF_01431};
GN   Name=rihA {ECO:0000255|HAMAP-Rule:MF_01431}; OrderedLocusNames=PBPRA2062;
OS   Photobacterium profundum (strain SS9).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Photobacterium.
OX   NCBI_TaxID=298386;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1253 / SS9;
RX   PubMed=15746425; DOI=10.1126/science.1103341;
RA   Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N., Lauro F.M.,
RA   Cestaro A., Malacrida G., Simionati B., Cannata N., Romualdi C.,
RA   Bartlett D.H., Valle G.;
RT   "Life at depth: Photobacterium profundum genome sequence and expression
RT   analysis.";
RL   Science 307:1459-1461(2005).
CC   -!- FUNCTION: Hydrolyzes cytidine or uridine to ribose and cytosine or
CC       uracil, respectively. {ECO:0000255|HAMAP-Rule:MF_01431}.
CC   -!- SIMILARITY: Belongs to the IUNH family. RihA subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01431}.
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DR   EMBL; CR378669; CAG20464.1; -; Genomic_DNA.
DR   RefSeq; WP_011218759.1; NC_006370.1.
DR   AlphaFoldDB; Q6LQG2; -.
DR   SMR; Q6LQG2; -.
DR   STRING; 298386.PBPRA2062; -.
DR   EnsemblBacteria; CAG20464; CAG20464; PBPRA2062.
DR   KEGG; ppr:PBPRA2062; -.
DR   eggNOG; COG1957; Bacteria.
DR   HOGENOM; CLU_036838_2_0_6; -.
DR   OMA; HAPDIHG; -.
DR   OrthoDB; 1763387at2; -.
DR   Proteomes; UP000000593; Chromosome 1.
DR   GO; GO:0045437; F:uridine nucleosidase activity; IEA:InterPro.
DR   GO; GO:0015949; P:nucleobase-containing small molecule interconversion; IEA:InterPro.
DR   GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.90.245.10; -; 1.
DR   HAMAP; MF_01431; Pyrim_hydro_RihA; 1.
DR   InterPro; IPR015910; I/U_nuclsd_hydro_CS.
DR   InterPro; IPR001910; Inosine/uridine_hydrolase_dom.
DR   InterPro; IPR023186; IUNH.
DR   InterPro; IPR022975; Pyrim_hydro_RihA.
DR   InterPro; IPR036452; Ribo_hydro-like.
DR   PANTHER; PTHR12304; PTHR12304; 1.
DR   Pfam; PF01156; IU_nuc_hydro; 1.
DR   SUPFAM; SSF53590; SSF53590; 1.
DR   PROSITE; PS01247; IUNH; 1.
PE   3: Inferred from homology;
KW   Glycosidase; Hydrolase; Reference proteome.
FT   CHAIN           1..310
FT                   /note="Pyrimidine-specific ribonucleoside hydrolase RihA"
FT                   /id="PRO_0000206816"
FT   ACT_SITE        240
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01431"
SQ   SEQUENCE   310 AA;  33719 MW;  0E8385B74D99E512 CRC64;
     MSRPIIIDCD PGHDDAIALI LACASPELDI KAVTTSAGNQ TPEKTLHNAL RILTLVGRTD
     IPVAGGALQP LSRELIIADN VHGETGLDGP VLPEPAFEPQ PCHAVELMAK ILTEATEPVT
     LVPTGPLTNI ALLLATHREL HSQIDSIVLM GGSAEAGNWT PAAEFNIYVD PEAADIVFKS
     GIPITMCGLD VTHRAQIMDE DIEKIRKINN PVAQVTAELL DFFMIYHRDP KWGFEGAPLH
     DPCTIAWLLE PELFASINCW VGIETQGSHT LGMTVVDRYQ LTDNPINTTV LFDVNRQGFV
     DLLAERLANY