ID   RIHA_SALAR              Reviewed;         311 AA.
AC   A9MKC6;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Pyrimidine-specific ribonucleoside hydrolase RihA {ECO:0000255|HAMAP-Rule:MF_01431};
DE            EC=3.2.-.- {ECO:0000255|HAMAP-Rule:MF_01431};
DE   AltName: Full=Cytidine/uridine-specific hydrolase {ECO:0000255|HAMAP-Rule:MF_01431};
GN   Name=rihA {ECO:0000255|HAMAP-Rule:MF_01431}; OrderedLocusNames=SARI_02282;
OS   Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=41514;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-731 / CDC346-86 / RSK2980;
RG   The Salmonella enterica serovar Arizonae Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S.,
RA   Fulton R., Chunyan W., Wollam A., Shah N., Pepin K., Bhonagiri V., Nash W.,
RA   Johnson M., Thiruvilangam P., Wilson R.;
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Hydrolyzes cytidine or uridine to ribose and cytosine or
CC       uracil, respectively. {ECO:0000255|HAMAP-Rule:MF_01431}.
CC   -!- SIMILARITY: Belongs to the IUNH family. RihA subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01431}.
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DR   EMBL; CP000880; ABX22145.1; -; Genomic_DNA.
DR   RefSeq; WP_001207443.1; NC_010067.1.
DR   AlphaFoldDB; A9MKC6; -.
DR   SMR; A9MKC6; -.
DR   STRING; 41514.SARI_02282; -.
DR   EnsemblBacteria; ABX22145; ABX22145; SARI_02282.
DR   KEGG; ses:SARI_02282; -.
DR   HOGENOM; CLU_036838_2_0_6; -.
DR   OMA; HAPDIHG; -.
DR   OrthoDB; 1763387at2; -.
DR   Proteomes; UP000002084; Chromosome.
DR   GO; GO:0045437; F:uridine nucleosidase activity; IEA:InterPro.
DR   GO; GO:0015949; P:nucleobase-containing small molecule interconversion; IEA:InterPro.
DR   GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.90.245.10; -; 1.
DR   HAMAP; MF_01431; Pyrim_hydro_RihA; 1.
DR   InterPro; IPR015910; I/U_nuclsd_hydro_CS.
DR   InterPro; IPR001910; Inosine/uridine_hydrolase_dom.
DR   InterPro; IPR023186; IUNH.
DR   InterPro; IPR022975; Pyrim_hydro_RihA.
DR   InterPro; IPR036452; Ribo_hydro-like.
DR   PANTHER; PTHR12304; PTHR12304; 1.
DR   Pfam; PF01156; IU_nuc_hydro; 1.
DR   SUPFAM; SSF53590; SSF53590; 1.
DR   PROSITE; PS01247; IUNH; 1.
PE   3: Inferred from homology;
KW   Glycosidase; Hydrolase; Reference proteome.
FT   CHAIN           1..311
FT                   /note="Pyrimidine-specific ribonucleoside hydrolase RihA"
FT                   /id="PRO_1000087435"
FT   ACT_SITE        240
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01431"
SQ   SEQUENCE   311 AA;  33747 MW;  73E07A2C96103CA0 CRC64;
     MALPIILDCD PGHDDAIAIV LALASPELDV KAITSSAGNQ TPDKTLRNVL RMLTLLKRSD
     IPVAGGAVKP LMRELIIADN VHGESGLDGP ALPEPSFAPQ NCTAVELMAK TLRESPQPVT
     LVATGPQTNV ALLLNSHPEL HAKIARIVIM GGAMGLGNWT PAAEFNIYVD PEAAEIVFQS
     GIPVLMAGLD VTHKAQIHTA DIERFRAIGN PISTIVAELL DFFLEYHKDE KWGFTGAPLH
     DPCTIAWLLK AELFTTVERW VGVETQGKYT QGMTVVDYYF LTGNKPNATV MVDVDREGFV
     DLLAERLKFY G