ID   RIHA_SALNS              Reviewed;         311 AA.
AC   B4SYM0;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Pyrimidine-specific ribonucleoside hydrolase RihA {ECO:0000255|HAMAP-Rule:MF_01431};
DE            EC=3.2.-.- {ECO:0000255|HAMAP-Rule:MF_01431};
DE   AltName: Full=Cytidine/uridine-specific hydrolase {ECO:0000255|HAMAP-Rule:MF_01431};
GN   Name=rihA {ECO:0000255|HAMAP-Rule:MF_01431};
GN   OrderedLocusNames=SNSL254_A0718;
OS   Salmonella newport (strain SL254).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=423368;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SL254;
RX   PubMed=21602358; DOI=10.1128/jb.00297-11;
RA   Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G.,
RA   Leclerc J.E., Ravel J., Cebula T.A.;
RT   "Comparative genomics of 28 Salmonella enterica isolates: evidence for
RT   CRISPR-mediated adaptive sublineage evolution.";
RL   J. Bacteriol. 193:3556-3568(2011).
CC   -!- FUNCTION: Hydrolyzes cytidine or uridine to ribose and cytosine or
CC       uracil, respectively. {ECO:0000255|HAMAP-Rule:MF_01431}.
CC   -!- SIMILARITY: Belongs to the IUNH family. RihA subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01431}.
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DR   EMBL; CP001113; ACF64883.1; -; Genomic_DNA.
DR   RefSeq; WP_001207486.1; NZ_CCMR01000003.1.
DR   AlphaFoldDB; B4SYM0; -.
DR   SMR; B4SYM0; -.
DR   EnsemblBacteria; ACF64883; ACF64883; SNSL254_A0718.
DR   KEGG; see:SNSL254_A0718; -.
DR   HOGENOM; CLU_036838_2_0_6; -.
DR   OMA; VYFGPGF; -.
DR   Proteomes; UP000008824; Chromosome.
DR   GO; GO:0045437; F:uridine nucleosidase activity; IEA:InterPro.
DR   GO; GO:0015949; P:nucleobase-containing small molecule interconversion; IEA:InterPro.
DR   GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.90.245.10; -; 1.
DR   HAMAP; MF_01431; Pyrim_hydro_RihA; 1.
DR   InterPro; IPR015910; I/U_nuclsd_hydro_CS.
DR   InterPro; IPR001910; Inosine/uridine_hydrolase_dom.
DR   InterPro; IPR023186; IUNH.
DR   InterPro; IPR022975; Pyrim_hydro_RihA.
DR   InterPro; IPR036452; Ribo_hydro-like.
DR   PANTHER; PTHR12304; PTHR12304; 1.
DR   Pfam; PF01156; IU_nuc_hydro; 1.
DR   SUPFAM; SSF53590; SSF53590; 1.
DR   PROSITE; PS01247; IUNH; 1.
PE   3: Inferred from homology;
KW   Glycosidase; Hydrolase.
FT   CHAIN           1..311
FT                   /note="Pyrimidine-specific ribonucleoside hydrolase RihA"
FT                   /id="PRO_1000145803"
FT   ACT_SITE        240
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01431"
SQ   SEQUENCE   311 AA;  33961 MW;  71D3C95DD0A8EA00 CRC64;
     MALPILFDCD PGHDDAIAIV LALASPELDV KAITSSAGNQ TPDKTLRNVL RMLTLLNRTD
     ISVAGGAVKP LMRDLIIADN VHGESGLDGP ALPEPAFAPL DCTAVELMAK VLRESPEPVT
     IVSTGPQTNV ALLLNSHPEL HAKIARIVIM GGAMGLGNWT PAAEFNIYVD PEAAEIVFQS
     GIRVVMAGLD VTHKAQIHRE DTERFRAIGN PVSTIVAELL DFFFEYHKDE KWGFIGAPLH
     DPCTIAWLLK PELFTTVERW VGVETQGKYT QGMTVVDYYF LSGNKPNATV MVDVDRQGFV
     DLLAERLQYY A