ID   RIHA_SALTY              Reviewed;         311 AA.
AC   Q8ZQY4;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Pyrimidine-specific ribonucleoside hydrolase RihA {ECO:0000255|HAMAP-Rule:MF_01431};
DE            EC=3.2.-.- {ECO:0000255|HAMAP-Rule:MF_01431};
DE   AltName: Full=Cytidine/uridine-specific hydrolase {ECO:0000255|HAMAP-Rule:MF_01431};
GN   Name=rihA {ECO:0000255|HAMAP-Rule:MF_01431}; OrderedLocusNames=STM0661;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Hydrolyzes cytidine or uridine to ribose and cytosine or
CC       uracil, respectively. {ECO:0000255|HAMAP-Rule:MF_01431}.
CC   -!- SIMILARITY: Belongs to the IUNH family. RihA subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01431}.
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DR   EMBL; AE006468; AAL19612.1; -; Genomic_DNA.
DR   RefSeq; NP_459653.1; NC_003197.2.
DR   RefSeq; WP_001207419.1; NC_003197.2.
DR   AlphaFoldDB; Q8ZQY4; -.
DR   SMR; Q8ZQY4; -.
DR   STRING; 99287.STM0661; -.
DR   PaxDb; Q8ZQY4; -.
DR   EnsemblBacteria; AAL19612; AAL19612; STM0661.
DR   GeneID; 1252181; -.
DR   KEGG; stm:STM0661; -.
DR   PATRIC; fig|99287.12.peg.697; -.
DR   HOGENOM; CLU_036838_2_0_6; -.
DR   OMA; HAPDIHG; -.
DR   PhylomeDB; Q8ZQY4; -.
DR   BioCyc; SENT99287:STM0661-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0008477; F:purine nucleosidase activity; IBA:GO_Central.
DR   GO; GO:0045437; F:uridine nucleosidase activity; IEA:InterPro.
DR   GO; GO:0015949; P:nucleobase-containing small molecule interconversion; IEA:InterPro.
DR   GO; GO:0006152; P:purine nucleoside catabolic process; IBA:GO_Central.
DR   GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.90.245.10; -; 1.
DR   HAMAP; MF_01431; Pyrim_hydro_RihA; 1.
DR   InterPro; IPR015910; I/U_nuclsd_hydro_CS.
DR   InterPro; IPR001910; Inosine/uridine_hydrolase_dom.
DR   InterPro; IPR023186; IUNH.
DR   InterPro; IPR022975; Pyrim_hydro_RihA.
DR   InterPro; IPR036452; Ribo_hydro-like.
DR   PANTHER; PTHR12304; PTHR12304; 1.
DR   Pfam; PF01156; IU_nuc_hydro; 1.
DR   SUPFAM; SSF53590; SSF53590; 1.
DR   PROSITE; PS01247; IUNH; 1.
PE   3: Inferred from homology;
KW   Glycosidase; Hydrolase; Reference proteome.
FT   CHAIN           1..311
FT                   /note="Pyrimidine-specific ribonucleoside hydrolase RihA"
FT                   /id="PRO_0000206820"
FT   ACT_SITE        240
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01431"
SQ   SEQUENCE   311 AA;  33789 MW;  958853FC624C7B8E CRC64;
     MALPIIIDCD PGHDDAIALV LALASPELEV KAITSSAGNQ TPEKTLRNVL RMLTLLKRLD
     IPVAGGAVKP LMRELIIADN VHGESGLDGP ALPEPSFAPQ SGTAVELMAK TLRESAQPVT
     IVSTGPQTNV ALLLNSHPEL HTKIARIVIM GGAMALGNWT PAAEFNIYVD PEAAEIVFQS
     GIPVVMAGLD VTHKAQIHAA DIERFRAIGN PISTIVAELL DFFMEYHKDE KWGFVGAPLH
     DPCTIAWLLK PEIFTTVERW VGVETQGKYT QGMTVVDYYF LTGNKPNATV MVDVDRQGFV
     DLLAERLQYY A