ID   RIHA_SHESA              Reviewed;         318 AA.
AC   A0L0Y0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Pyrimidine-specific ribonucleoside hydrolase RihA {ECO:0000255|HAMAP-Rule:MF_01431};
DE            EC=3.2.-.- {ECO:0000255|HAMAP-Rule:MF_01431};
DE   AltName: Full=Cytidine/uridine-specific hydrolase {ECO:0000255|HAMAP-Rule:MF_01431};
GN   Name=rihA {ECO:0000255|HAMAP-Rule:MF_01431};
GN   OrderedLocusNames=Shewana3_3476;
OS   Shewanella sp. (strain ANA-3).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=94122;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ANA-3;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Newman D.,
RA   Salticov C., Konstantinidis K., Klappenback J., Tiedje J., Richardson P.;
RT   "Complete sequence of chromosome 1 of Shewanella sp. ANA-3.";
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Hydrolyzes cytidine or uridine to ribose and cytosine or
CC       uracil, respectively. {ECO:0000255|HAMAP-Rule:MF_01431}.
CC   -!- SIMILARITY: Belongs to the IUNH family. RihA subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01431}.
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DR   EMBL; CP000469; ABK49699.1; -; Genomic_DNA.
DR   RefSeq; WP_011718268.1; NC_008577.1.
DR   AlphaFoldDB; A0L0Y0; -.
DR   SMR; A0L0Y0; -.
DR   STRING; 94122.Shewana3_3476; -.
DR   EnsemblBacteria; ABK49699; ABK49699; Shewana3_3476.
DR   KEGG; shn:Shewana3_3476; -.
DR   eggNOG; COG1957; Bacteria.
DR   HOGENOM; CLU_036838_2_0_6; -.
DR   OMA; VYFGPGF; -.
DR   OrthoDB; 1763387at2; -.
DR   Proteomes; UP000002589; Chromosome.
DR   GO; GO:0045437; F:uridine nucleosidase activity; IEA:InterPro.
DR   GO; GO:0015949; P:nucleobase-containing small molecule interconversion; IEA:InterPro.
DR   GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.90.245.10; -; 1.
DR   HAMAP; MF_01431; Pyrim_hydro_RihA; 1.
DR   InterPro; IPR015910; I/U_nuclsd_hydro_CS.
DR   InterPro; IPR001910; Inosine/uridine_hydrolase_dom.
DR   InterPro; IPR023186; IUNH.
DR   InterPro; IPR022975; Pyrim_hydro_RihA.
DR   InterPro; IPR036452; Ribo_hydro-like.
DR   PANTHER; PTHR12304; PTHR12304; 1.
DR   Pfam; PF01156; IU_nuc_hydro; 1.
DR   SUPFAM; SSF53590; SSF53590; 1.
DR   PROSITE; PS01247; IUNH; 1.
PE   3: Inferred from homology;
KW   Glycosidase; Hydrolase.
FT   CHAIN           1..318
FT                   /note="Pyrimidine-specific ribonucleoside hydrolase RihA"
FT                   /id="PRO_1000024399"
FT   ACT_SITE        240
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01431"
SQ   SEQUENCE   318 AA;  34289 MW;  D98AE7FAFEBE4DFA CRC64;
     MSRPIILDCD PGHDDAIALI LALAHPELTP LAVTTSAGNQ TPDKTLNNAL RILTLLNRSD
     IPVAGGAVKP LSRELMIADN VHGETGLDGP ALPAPSFQPQ AVNAVELMAE KIRQSDKPVT
     LVPTGPLTNI ALLLASHAEL HAKIERIVLM GGAAGVGNWT PAAEFNIFVD PEAADIVFKS
     GIPITMCGLD VTHQAQIMDE DIERIRAIAN PVAKCVAELL DFFMIYHRDP KWGFVGAPLH
     DPCTIAWLLN PALFDAQDCW VGIETQSELT LGMTVVDRYQ LTGKPANATV LFGIDRQGFV
     DLLVDSLAVY TPTYLNRR