ID   RIHA_SHESR              Reviewed;         318 AA.
AC   Q0HZ05;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Pyrimidine-specific ribonucleoside hydrolase RihA {ECO:0000255|HAMAP-Rule:MF_01431};
DE            EC=3.2.-.- {ECO:0000255|HAMAP-Rule:MF_01431};
DE   AltName: Full=Cytidine/uridine-specific hydrolase {ECO:0000255|HAMAP-Rule:MF_01431};
GN   Name=rihA {ECO:0000255|HAMAP-Rule:MF_01431};
GN   OrderedLocusNames=Shewmr7_0647;
OS   Shewanella sp. (strain MR-7).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=60481;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MR-7;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Nealson K.,
RA   Konstantinidis K., Klappenbach J., Tiedje J., Richardson P.;
RT   "Complete sequence of chromosome 1 of Shewanella sp. MR-7.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Hydrolyzes cytidine or uridine to ribose and cytosine or
CC       uracil, respectively. {ECO:0000255|HAMAP-Rule:MF_01431}.
CC   -!- SIMILARITY: Belongs to the IUNH family. RihA subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01431}.
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DR   EMBL; CP000444; ABI41650.1; -; Genomic_DNA.
DR   RefSeq; WP_011625142.1; NC_008322.1.
DR   AlphaFoldDB; Q0HZ05; -.
DR   SMR; Q0HZ05; -.
DR   EnsemblBacteria; ABI41650; ABI41650; Shewmr7_0647.
DR   KEGG; shm:Shewmr7_0647; -.
DR   HOGENOM; CLU_036838_2_0_6; -.
DR   OMA; VYFGPGF; -.
DR   OrthoDB; 1763387at2; -.
DR   GO; GO:0045437; F:uridine nucleosidase activity; IEA:InterPro.
DR   GO; GO:0015949; P:nucleobase-containing small molecule interconversion; IEA:InterPro.
DR   GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.90.245.10; -; 1.
DR   HAMAP; MF_01431; Pyrim_hydro_RihA; 1.
DR   InterPro; IPR015910; I/U_nuclsd_hydro_CS.
DR   InterPro; IPR001910; Inosine/uridine_hydrolase_dom.
DR   InterPro; IPR023186; IUNH.
DR   InterPro; IPR022975; Pyrim_hydro_RihA.
DR   InterPro; IPR036452; Ribo_hydro-like.
DR   PANTHER; PTHR12304; PTHR12304; 1.
DR   Pfam; PF01156; IU_nuc_hydro; 1.
DR   SUPFAM; SSF53590; SSF53590; 1.
DR   PROSITE; PS01247; IUNH; 1.
PE   3: Inferred from homology;
KW   Glycosidase; Hydrolase.
FT   CHAIN           1..318
FT                   /note="Pyrimidine-specific ribonucleoside hydrolase RihA"
FT                   /id="PRO_1000024401"
FT   ACT_SITE        240
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01431"
SQ   SEQUENCE   318 AA;  34314 MW;  1357C6DC0D9543BE CRC64;
     MSRPIILDCD PGHDDAIALI LALAHPELNP LAVTTSAGNQ TPDKTLKNAL RILTLLNRSD
     IPVAGGAVKP LSRELMIADN VHGETGLDGP ALPAPSFQPQ AVNAVELMAE KIRQSDKPVT
     LVPTGPLTNI ALLLASHGEL HAKIERIVLM GGAAGVGNWT PAAEFNIFVD PEAADIVFKS
     GIPITMCGLD VTHQAQIMDE DIERIRAIPN PVAKCVAELL DFFMIYHRAP KWGFVGAPLH
     DPCTIAWLLN PALFDAQDCW VGIETQSELT LGMTVVDRYQ LTGKPTNATV LFGIDRQGFV
     DLLVDSLAVY TPTYLNRR