ID   RIHA_SHEWM              Reviewed;         312 AA.
AC   B1KHA5;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Pyrimidine-specific ribonucleoside hydrolase RihA {ECO:0000255|HAMAP-Rule:MF_01431};
DE            EC=3.2.-.- {ECO:0000255|HAMAP-Rule:MF_01431};
DE   AltName: Full=Cytidine/uridine-specific hydrolase {ECO:0000255|HAMAP-Rule:MF_01431};
GN   Name=rihA {ECO:0000255|HAMAP-Rule:MF_01431}; OrderedLocusNames=Swoo_1120;
OS   Shewanella woodyi (strain ATCC 51908 / MS32).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=392500;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51908 / MS32;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C.,
RA   Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Lykidis A., Zhao J.-S., Richardson P.;
RT   "Complete sequence of Shewanella woodyi ATCC 51908.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Hydrolyzes cytidine or uridine to ribose and cytosine or
CC       uracil, respectively. {ECO:0000255|HAMAP-Rule:MF_01431}.
CC   -!- SIMILARITY: Belongs to the IUNH family. RihA subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01431}.
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DR   EMBL; CP000961; ACA85413.1; -; Genomic_DNA.
DR   RefSeq; WP_012323759.1; NC_010506.1.
DR   AlphaFoldDB; B1KHA5; -.
DR   SMR; B1KHA5; -.
DR   STRING; 392500.Swoo_1120; -.
DR   EnsemblBacteria; ACA85413; ACA85413; Swoo_1120.
DR   KEGG; swd:Swoo_1120; -.
DR   eggNOG; COG1957; Bacteria.
DR   HOGENOM; CLU_036838_2_0_6; -.
DR   OMA; FIFEHEV; -.
DR   OrthoDB; 1763387at2; -.
DR   Proteomes; UP000002168; Chromosome.
DR   GO; GO:0045437; F:uridine nucleosidase activity; IEA:InterPro.
DR   GO; GO:0015949; P:nucleobase-containing small molecule interconversion; IEA:InterPro.
DR   GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.90.245.10; -; 1.
DR   HAMAP; MF_01431; Pyrim_hydro_RihA; 1.
DR   InterPro; IPR015910; I/U_nuclsd_hydro_CS.
DR   InterPro; IPR001910; Inosine/uridine_hydrolase_dom.
DR   InterPro; IPR023186; IUNH.
DR   InterPro; IPR022975; Pyrim_hydro_RihA.
DR   InterPro; IPR036452; Ribo_hydro-like.
DR   PANTHER; PTHR12304; PTHR12304; 1.
DR   Pfam; PF01156; IU_nuc_hydro; 1.
DR   SUPFAM; SSF53590; SSF53590; 1.
DR   PROSITE; PS01247; IUNH; 1.
PE   3: Inferred from homology;
KW   Glycosidase; Hydrolase; Reference proteome.
FT   CHAIN           1..312
FT                   /note="Pyrimidine-specific ribonucleoside hydrolase RihA"
FT                   /id="PRO_1000145806"
FT   ACT_SITE        240
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01431"
SQ   SEQUENCE   312 AA;  33384 MW;  93A7A3EDEE8B0C76 CRC64;
     MTRPIILDCD PGHDDAIAII LALSSDAFSP LAVTTSAGNQ TPDKTLNNAL RILTLLGRSD
     IPVAGGAVKP LARELIIADN VHGETGLDGP VLPDPSFAPQ AMTAVELMAL KIKQSQAPVT
     LVPTGPLTNI ALLLATHPEL HSNIEQIVLM GGAAGVGNWT PAAEFNIFVD PEAADMVFKA
     GIPITMCGLD VTHQAQVMDE DIARIRAIEN PIAQCVADLL DFFILYHRDP KWGFTGAPLH
     DPCTIAWLLK PELFTAQQAW VGIETKGEHT QGMTVVDRYG LTGNQANATV LFDIDRAGFI
     DLLAQSLETY SR