ID   RIHC_KLEP7              Reviewed;         304 AA.
AC   A6T4G4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Non-specific ribonucleoside hydrolase RihC {ECO:0000255|HAMAP-Rule:MF_01432};
DE            EC=3.2.-.- {ECO:0000255|HAMAP-Rule:MF_01432};
DE   AltName: Full=Purine/pyrimidine ribonucleoside hydrolase {ECO:0000255|HAMAP-Rule:MF_01432};
GN   Name=rihC {ECO:0000255|HAMAP-Rule:MF_01432};
GN   OrderedLocusNames=KPN78578_00240; ORFNames=KPN_00025;
OS   Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=272620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700721 / MGH 78578;
RG   The Klebsiella pneumonia Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P.,
RA   Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Hydrolyzes both purine and pyrimidine ribonucleosides with a
CC       broad-substrate specificity. {ECO:0000255|HAMAP-Rule:MF_01432}.
CC   -!- SIMILARITY: Belongs to the IUNH family. RihC subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01432}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000647; ABR75485.1; -; Genomic_DNA.
DR   RefSeq; WP_002887981.1; NC_009648.1.
DR   AlphaFoldDB; A6T4G4; -.
DR   SMR; A6T4G4; -.
DR   STRING; 272620.KPN_00025; -.
DR   jPOST; A6T4G4; -.
DR   EnsemblBacteria; ABR75485; ABR75485; KPN_00025.
DR   KEGG; kpn:KPN_00025; -.
DR   HOGENOM; CLU_036838_2_2_6; -.
DR   OMA; TPVAEWN; -.
DR   Proteomes; UP000000265; Chromosome.
DR   GO; GO:0016799; F:hydrolase activity, hydrolyzing N-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0006144; P:purine nucleobase metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.90.245.10; -; 1.
DR   HAMAP; MF_01432; Nucleosid_hydro_RihC; 1.
DR   InterPro; IPR001910; Inosine/uridine_hydrolase_dom.
DR   InterPro; IPR023186; IUNH.
DR   InterPro; IPR022976; Nucleosid_hydro_RihC_nonspecif.
DR   InterPro; IPR036452; Ribo_hydro-like.
DR   PANTHER; PTHR12304; PTHR12304; 1.
DR   Pfam; PF01156; IU_nuc_hydro; 1.
DR   SUPFAM; SSF53590; SSF53590; 1.
PE   3: Inferred from homology;
KW   Glycosidase; Hydrolase; Reference proteome.
FT   CHAIN           1..304
FT                   /note="Non-specific ribonucleoside hydrolase RihC"
FT                   /id="PRO_1000024407"
FT   ACT_SITE        233
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01432"
SQ   SEQUENCE   304 AA;  32675 MW;  E057393F002AD608 CRC64;
     MRLPIILDTD PGIDDAAAIA AALFAPELDL QLMTTVAGNV SVEKTTRNAL QLLHFWNADV
     PLAQGASMPL VRPLRDAASV HGESGMEGYD FVEHQRQPLA KPAFQAIRDA LMHAAEPITL
     VAIGPLTNIA LLLTQYPECV FNIRRLVIMG GSAGRGNFTP NAEFNIAIDP EAAAKVFHSG
     LEIVMCGLDV TNRALLAADY LATLPTLNQT GKMLHALFSH YRSGSMSSGL RMHDLCAIAW
     LARPELFTLQ PCFVAVETQG TWTAGTTVVD IEGRLGQPAN AQVALDIDVE GFQRWAAEVI
     ALAP