ID   RIHC_SALTI              Reviewed;         306 AA.
AC   Q8Z9M9; Q7CBX4;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Non-specific ribonucleoside hydrolase RihC {ECO:0000255|HAMAP-Rule:MF_01432};
DE            EC=3.2.-.- {ECO:0000255|HAMAP-Rule:MF_01432};
DE   AltName: Full=Purine/pyrimidine ribonucleoside hydrolase {ECO:0000255|HAMAP-Rule:MF_01432};
GN   Name=rihC {ECO:0000255|HAMAP-Rule:MF_01432};
GN   OrderedLocusNames=STY0060, t0053;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: Hydrolyzes both purine and pyrimidine ribonucleosides with a
CC       broad-substrate specificity. {ECO:0000255|HAMAP-Rule:MF_01432}.
CC   -!- SIMILARITY: Belongs to the IUNH family. RihC subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01432}.
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DR   EMBL; AL513382; CAD01206.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO67786.1; -; Genomic_DNA.
DR   RefSeq; NP_454662.1; NC_003198.1.
DR   RefSeq; WP_000127280.1; NZ_WSUR01000014.1.
DR   AlphaFoldDB; Q8Z9M9; -.
DR   SMR; Q8Z9M9; -.
DR   STRING; 220341.16501335; -.
DR   EnsemblBacteria; AAO67786; AAO67786; t0053.
DR   KEGG; stt:t0053; -.
DR   KEGG; sty:STY0060; -.
DR   PATRIC; fig|220341.7.peg.60; -.
DR   eggNOG; COG1957; Bacteria.
DR   HOGENOM; CLU_036838_2_2_6; -.
DR   OMA; TPVAEWN; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0016799; F:hydrolase activity, hydrolyzing N-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0006144; P:purine nucleobase metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.90.245.10; -; 1.
DR   HAMAP; MF_01432; Nucleosid_hydro_RihC; 1.
DR   InterPro; IPR001910; Inosine/uridine_hydrolase_dom.
DR   InterPro; IPR023186; IUNH.
DR   InterPro; IPR022976; Nucleosid_hydro_RihC_nonspecif.
DR   InterPro; IPR036452; Ribo_hydro-like.
DR   PANTHER; PTHR12304; PTHR12304; 1.
DR   Pfam; PF01156; IU_nuc_hydro; 1.
DR   SUPFAM; SSF53590; SSF53590; 1.
PE   3: Inferred from homology;
KW   Glycosidase; Hydrolase.
FT   CHAIN           1..306
FT                   /note="Non-specific ribonucleoside hydrolase RihC"
FT                   /id="PRO_0000206836"
FT   ACT_SITE        235
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01432"
SQ   SEQUENCE   306 AA;  33151 MW;  A305102C79D1DEE2 CRC64;
     MTASLHIILD TDPGIDDAAA IAAALFAPQL DLQLITTVAG NVSVEKTTRN ALQLLHFWNS
     DIPLAQGAAT PLLRPLRDAA YVHGESGMEG YDFVDHQRQP LAKPAFIAIR DVLMNAPEPM
     TLVAIGPLTN IALLLMHYPE CACNIRRLVL MGGSAGRGNF TPNAEFNIAV DPEAAALVFR
     SGLEIVMCGL DVTNQAMLSP DFLNKLPALN RTGKMLHSLF NHYRSGSMRT GVRMHDLCAI
     AWLVRPELFT LQSCFVAVET QGEYTAGTTV VDIEGRLGQP ANAQVALALD VDGFRQWVAE
     VFAYVP