RIHC_SHIBS
ID RIHC_SHIBS Reviewed; 304 AA.
AC Q326J3;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Non-specific ribonucleoside hydrolase RihC {ECO:0000255|HAMAP-Rule:MF_01432};
DE EC=3.2.-.- {ECO:0000255|HAMAP-Rule:MF_01432};
DE AltName: Full=Purine/pyrimidine ribonucleoside hydrolase {ECO:0000255|HAMAP-Rule:MF_01432};
GN Name=rihC {ECO:0000255|HAMAP-Rule:MF_01432}; OrderedLocusNames=SBO_0029;
OS Shigella boydii serotype 4 (strain Sb227).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=300268;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Sb227;
RX PubMed=16275786; DOI=10.1093/nar/gki954;
RA Yang F., Yang J., Zhang X., Chen L., Jiang Y., Yan Y., Tang X., Wang J.,
RA Xiong Z., Dong J., Xue Y., Zhu Y., Xu X., Sun L., Chen S., Nie H., Peng J.,
RA Xu J., Wang Y., Yuan Z., Wen Y., Yao Z., Shen Y., Qiang B., Hou Y., Yu J.,
RA Jin Q.;
RT "Genome dynamics and diversity of Shigella species, the etiologic agents of
RT bacillary dysentery.";
RL Nucleic Acids Res. 33:6445-6458(2005).
CC -!- FUNCTION: Hydrolyzes both purine and pyrimidine ribonucleosides with a
CC broad-substrate specificity. {ECO:0000255|HAMAP-Rule:MF_01432}.
CC -!- SIMILARITY: Belongs to the IUNH family. RihC subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01432}.
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DR EMBL; CP000036; ABB64765.1; -; Genomic_DNA.
DR RefSeq; WP_000550596.1; NC_007613.1.
DR AlphaFoldDB; Q326J3; -.
DR SMR; Q326J3; -.
DR EnsemblBacteria; ABB64765; ABB64765; SBO_0029.
DR KEGG; sbo:SBO_0029; -.
DR HOGENOM; CLU_036838_2_2_6; -.
DR OMA; TPVAEWN; -.
DR Proteomes; UP000007067; Chromosome.
DR GO; GO:0045437; F:uridine nucleosidase activity; IEA:UniProt.
DR GO; GO:0006144; P:purine nucleobase metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.90.245.10; -; 1.
DR HAMAP; MF_01432; Nucleosid_hydro_RihC; 1.
DR InterPro; IPR015910; I/U_nuclsd_hydro_CS.
DR InterPro; IPR001910; Inosine/uridine_hydrolase_dom.
DR InterPro; IPR023186; IUNH.
DR InterPro; IPR022976; Nucleosid_hydro_RihC_nonspecif.
DR InterPro; IPR036452; Ribo_hydro-like.
DR PANTHER; PTHR12304; PTHR12304; 1.
DR Pfam; PF01156; IU_nuc_hydro; 1.
DR SUPFAM; SSF53590; SSF53590; 1.
DR PROSITE; PS01247; IUNH; 1.
PE 3: Inferred from homology;
KW Glycosidase; Hydrolase.
FT CHAIN 1..304
FT /note="Non-specific ribonucleoside hydrolase RihC"
FT /id="PRO_1000024408"
FT ACT_SITE 233
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01432"
SQ SEQUENCE 304 AA; 32525 MW; 23438ECC42C74FA1 CRC64;
MHLPIFLDTD PGIDDAVAIA AAIFAPELDL QLMTTVAGNV SVEKTTRNAL QLLHFWNAEI
PLAQGAAVPL VRAPRDAASV HGESGMAGYD FVEHNRKPLG IPAFLAIRDA LMRAPEPVTL
VAIGPLTNIA LLLSQCPECK PYIRRLVIMG GSAGRGNCTP NAEFNIAADP EAAACVFRSG
IEIVMSGLDV TNQAILTPDY LATLPELNRT GKMLHALFSH YRSGSMQSGL RMHDLCAIAW
LVRPELFTLK PCFVAVETQG EFTSGTTVVD IDGCLGKPAN VKVALDLDVK GFQQWVAEVL
ALAS