ID   RIHC_SHIDS              Reviewed;         304 AA.
AC   Q32K67;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Non-specific ribonucleoside hydrolase RihC {ECO:0000255|HAMAP-Rule:MF_01432};
DE            EC=3.2.-.- {ECO:0000255|HAMAP-Rule:MF_01432};
DE   AltName: Full=Purine/pyrimidine ribonucleoside hydrolase {ECO:0000255|HAMAP-Rule:MF_01432};
GN   Name=rihC {ECO:0000255|HAMAP-Rule:MF_01432}; OrderedLocusNames=SDY_0052;
OS   Shigella dysenteriae serotype 1 (strain Sd197).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=300267;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Sd197;
RX   PubMed=16275786; DOI=10.1093/nar/gki954;
RA   Yang F., Yang J., Zhang X., Chen L., Jiang Y., Yan Y., Tang X., Wang J.,
RA   Xiong Z., Dong J., Xue Y., Zhu Y., Xu X., Sun L., Chen S., Nie H., Peng J.,
RA   Xu J., Wang Y., Yuan Z., Wen Y., Yao Z., Shen Y., Qiang B., Hou Y., Yu J.,
RA   Jin Q.;
RT   "Genome dynamics and diversity of Shigella species, the etiologic agents of
RT   bacillary dysentery.";
RL   Nucleic Acids Res. 33:6445-6458(2005).
CC   -!- FUNCTION: Hydrolyzes both purine and pyrimidine ribonucleosides with a
CC       broad-substrate specificity. {ECO:0000255|HAMAP-Rule:MF_01432}.
CC   -!- SIMILARITY: Belongs to the IUNH family. RihC subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01432}.
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DR   EMBL; CP000034; ABB60290.1; -; Genomic_DNA.
DR   RefSeq; WP_001239123.1; NC_007606.1.
DR   RefSeq; YP_401779.1; NC_007606.1.
DR   AlphaFoldDB; Q32K67; -.
DR   SMR; Q32K67; -.
DR   STRING; 300267.SDY_0052; -.
DR   EnsemblBacteria; ABB60290; ABB60290; SDY_0052.
DR   KEGG; sdy:SDY_0052; -.
DR   PATRIC; fig|300267.13.peg.56; -.
DR   HOGENOM; CLU_036838_2_2_6; -.
DR   OMA; TPVAEWN; -.
DR   Proteomes; UP000002716; Chromosome.
DR   GO; GO:0045437; F:uridine nucleosidase activity; IEA:UniProt.
DR   GO; GO:0006144; P:purine nucleobase metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.90.245.10; -; 1.
DR   HAMAP; MF_01432; Nucleosid_hydro_RihC; 1.
DR   InterPro; IPR015910; I/U_nuclsd_hydro_CS.
DR   InterPro; IPR001910; Inosine/uridine_hydrolase_dom.
DR   InterPro; IPR023186; IUNH.
DR   InterPro; IPR022976; Nucleosid_hydro_RihC_nonspecif.
DR   InterPro; IPR036452; Ribo_hydro-like.
DR   PANTHER; PTHR12304; PTHR12304; 1.
DR   Pfam; PF01156; IU_nuc_hydro; 1.
DR   SUPFAM; SSF53590; SSF53590; 1.
DR   PROSITE; PS01247; IUNH; 1.
PE   3: Inferred from homology;
KW   Glycosidase; Hydrolase; Reference proteome.
FT   CHAIN           1..304
FT                   /note="Non-specific ribonucleoside hydrolase RihC"
FT                   /id="PRO_1000024409"
FT   ACT_SITE        233
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01432"
SQ   SEQUENCE   304 AA;  32561 MW;  55F8C0FB370ED472 CRC64;
     MRLPIFLDTD PGIDDAVAIA AAIFAPELDL QLMTTVAGNV SVEKTTRNAL QLLHFWNAEI
     PLAQGAAVPL VRAPRDAASV HGESGMAGYD FVEHNRKPLG IPAFLAIRDA LMCAPEPVTL
     VAIGPLTNIA LLLSQCPECK PYIRRLVIMG GSAGRGNCTP NAEFNIAADP EAAACVFRSG
     IEIVMCGLDV TNQAILTPDY LATLPELNRT GKMLHALFSH YRSGSMQSGL RMHDLCAIAW
     LVRPDLFTLK PCFVAVETQG EFTSGTTVVD IDGCRGKPAN VQVALDLNVK GFQQWVPEVL
     ALAS