RIM3A_HUMAN
ID RIM3A_HUMAN Reviewed; 1639 AA.
AC Q9UFD9; Q8IYP7; Q9BY94; Q9UFQ5;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2012, sequence version 4.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=RIMS-binding protein 3A;
DE Short=RIM-BP3.A;
DE AltName: Full=RIMS-binding protein 3.1;
DE Short=RIM-BP3.1;
GN Name=RIMBP3; Synonyms=KIAA1666, RIMBP3A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 50-1639, AND VARIANT CYS-1513.
RC TISSUE=Brain;
RX PubMed=11258795; DOI=10.1093/dnares/8.1.1;
RA Hirosawa M., Nagase T., Murahashi Y., Kikuno R., Ohara O.;
RT "Identification of novel transcribed sequences on human chromosome 22 by
RT expressed sequence tag mapping.";
RL DNA Res. 8:1-9(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 473-1639.
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 753-1639, AND VARIANT CYS-1513.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP STRUCTURE BY NMR OF 1572-1639.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of the third SH3 domain from human KIAA1666 protein.";
RL Submitted (AUG-2007) to the PDB data bank.
CC -!- FUNCTION: Probable component of the manchette, a microtubule-based
CC structure which plays a key role in sperm head morphogenesis during
CC late stages of sperm development. {ECO:0000250|UniProtKB:Q3V0F0}.
CC -!- SUBUNIT: Interacts with LRGUK (via guanylate kinase-like domain).
CC Interacts (via C-terminus) with HOOK1 (via coiled-coil region).
CC {ECO:0000250|UniProtKB:Q3V0F0}.
CC -!- INTERACTION:
CC Q9UFD9; Q9NQ94: A1CF; NbExp=3; IntAct=EBI-10182375, EBI-2809489;
CC Q9UFD9; P29972: AQP1; NbExp=3; IntAct=EBI-10182375, EBI-745213;
CC Q9UFD9; Q6P5X5: C22orf39; NbExp=3; IntAct=EBI-10182375, EBI-7317823;
CC Q9UFD9; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-10182375, EBI-744545;
CC Q9UFD9; Q02930-3: CREB5; NbExp=3; IntAct=EBI-10182375, EBI-10192698;
CC Q9UFD9; P56545-3: CTBP2; NbExp=3; IntAct=EBI-10182375, EBI-10171902;
CC Q9UFD9; Q9BY27: DGCR6L; NbExp=3; IntAct=EBI-10182375, EBI-742953;
CC Q9UFD9; Q86UW9: DTX2; NbExp=3; IntAct=EBI-10182375, EBI-740376;
CC Q9UFD9; Q5JVL4: EFHC1; NbExp=3; IntAct=EBI-10182375, EBI-743105;
CC Q9UFD9; Q9NW38: FANCL; NbExp=3; IntAct=EBI-10182375, EBI-2339898;
CC Q9UFD9; O95363: FARS2; NbExp=3; IntAct=EBI-10182375, EBI-2513774;
CC Q9UFD9; O43559: FRS3; NbExp=3; IntAct=EBI-10182375, EBI-725515;
CC Q9UFD9; O95872: GPANK1; NbExp=3; IntAct=EBI-10182375, EBI-751540;
CC Q9UFD9; Q9C086: INO80B; NbExp=3; IntAct=EBI-10182375, EBI-715611;
CC Q9UFD9; Q8TCE9: LGALS14; NbExp=3; IntAct=EBI-10182375, EBI-10274069;
CC Q9UFD9; Q17RB8: LONRF1; NbExp=3; IntAct=EBI-10182375, EBI-2341787;
CC Q9UFD9; Q9HC98-4: NEK6; NbExp=3; IntAct=EBI-10182375, EBI-11750983;
CC Q9UFD9; Q86UR1: NOXA1; NbExp=4; IntAct=EBI-10182375, EBI-949814;
CC Q9UFD9; Q86UR1-2: NOXA1; NbExp=3; IntAct=EBI-10182375, EBI-12025760;
CC Q9UFD9; O15160: POLR1C; NbExp=6; IntAct=EBI-10182375, EBI-1055079;
CC Q9UFD9; Q9Y3C6: PPIL1; NbExp=3; IntAct=EBI-10182375, EBI-2557649;
CC Q9UFD9; Q7Z5V6-2: PPP1R32; NbExp=3; IntAct=EBI-10182375, EBI-12000762;
CC Q9UFD9; Q13131: PRKAA1; NbExp=3; IntAct=EBI-10182375, EBI-1181405;
CC Q9UFD9; O43741: PRKAB2; NbExp=4; IntAct=EBI-10182375, EBI-1053424;
CC Q9UFD9; Q96A09: TENT5B; NbExp=3; IntAct=EBI-10182375, EBI-752030;
CC Q9UFD9; Q08117: TLE5; NbExp=3; IntAct=EBI-10182375, EBI-717810;
CC Q9UFD9; O43734: TRAF3IP2; NbExp=3; IntAct=EBI-10182375, EBI-744798;
CC Q9UFD9; Q96MN9: ZNF488; NbExp=3; IntAct=EBI-10182375, EBI-948288;
CC Q9UFD9; Q9P0T4: ZNF581; NbExp=3; IntAct=EBI-10182375, EBI-745520;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000250|UniProtKB:Q3V0F0}. Note=In elongating spermatids,
CC localizes to the manchette. {ECO:0000250|UniProtKB:Q3V0F0}.
CC -!- SIMILARITY: Belongs to the RIMBP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH35246.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB33336.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAB61362.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC023490; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AB051453; BAB33336.1; ALT_FRAME; mRNA.
DR EMBL; AL117509; CAB55970.1; -; mRNA.
DR EMBL; AL133030; CAB61362.2; ALT_INIT; mRNA.
DR EMBL; BC035246; AAH35246.2; ALT_INIT; mRNA.
DR CCDS; CCDS46665.1; -.
DR PIR; T17280; T17280.
DR PIR; T42704; T42704.
DR RefSeq; NP_056487.1; NM_015672.1.
DR PDB; 2EGE; NMR; -; A=1572-1639.
DR PDBsum; 2EGE; -.
DR AlphaFoldDB; Q9UFD9; -.
DR SMR; Q9UFD9; -.
DR BioGRID; 124503; 28.
DR CORUM; Q9UFD9; -.
DR IntAct; Q9UFD9; 35.
DR STRING; 9606.ENSP00000483386; -.
DR iPTMnet; Q9UFD9; -.
DR PhosphoSitePlus; Q9UFD9; -.
DR BioMuta; RIMBP3; -.
DR DMDM; 380865484; -.
DR jPOST; Q9UFD9; -.
DR MassIVE; Q9UFD9; -.
DR MaxQB; Q9UFD9; -.
DR PaxDb; Q9UFD9; -.
DR PeptideAtlas; Q9UFD9; -.
DR PRIDE; Q9UFD9; -.
DR ProteomicsDB; 84178; -.
DR ABCD; Q9UFD9; 2 sequenced antibodies.
DR Antibodypedia; 72644; 60 antibodies from 14 providers.
DR DNASU; 85376; -.
DR Ensembl; ENST00000619918.1; ENSP00000483386.1; ENSG00000275793.1.
DR GeneID; 85376; -.
DR KEGG; hsa:85376; -.
DR MANE-Select; ENST00000619918.1; ENSP00000483386.1; NM_015672.2; NP_056487.1.
DR UCSC; uc002zsd.5; human.
DR CTD; 85376; -.
DR GeneCards; RIMBP3; -.
DR HGNC; HGNC:29344; RIMBP3.
DR HPA; ENSG00000275793; Group enriched (brain, choroid plexus, testis).
DR MIM; 612699; gene.
DR neXtProt; NX_Q9UFD9; -.
DR OpenTargets; ENSG00000275793; -.
DR VEuPathDB; HostDB:ENSG00000275793; -.
DR eggNOG; KOG3632; Eukaryota.
DR GeneTree; ENSGT00950000183203; -.
DR HOGENOM; CLU_001979_2_1_1; -.
DR InParanoid; Q9UFD9; -.
DR OMA; AQIPEDC; -.
DR OrthoDB; 102427at2759; -.
DR PhylomeDB; Q9UFD9; -.
DR TreeFam; TF316230; -.
DR PathwayCommons; Q9UFD9; -.
DR SignaLink; Q9UFD9; -.
DR SIGNOR; Q9UFD9; -.
DR BioGRID-ORCS; 85376; 17 hits in 619 CRISPR screens.
DR EvolutionaryTrace; Q9UFD9; -.
DR GenomeRNAi; 85376; -.
DR Pharos; Q9UFD9; Tdark.
DR PRO; PR:Q9UFD9; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q9UFD9; protein.
DR Bgee; ENSG00000275793; Expressed in left testis and 51 other tissues.
DR Genevisible; Q9UFD9; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0030156; F:benzodiazepine receptor binding; IBA:GO_Central.
DR GO; GO:0009566; P:fertilization; IBA:GO_Central.
DR GO; GO:0007286; P:spermatid development; IBA:GO_Central.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR040325; RIMBP1/2/3.
DR InterPro; IPR035515; Rimbp3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR14234; PTHR14234; 1.
DR PANTHER; PTHR14234:SF21; PTHR14234:SF21; 1.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00326; SH3; 3.
DR SUPFAM; SSF49265; SSF49265; 1.
DR SUPFAM; SSF50044; SSF50044; 3.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50002; SH3; 3.
PE 1: Evidence at protein level;
KW 3D-structure; Coiled coil; Cytoplasm; Cytoskeleton; Differentiation;
KW Reference proteome; Repeat; SH3 domain; Spermatogenesis.
FT CHAIN 1..1639
FT /note="RIMS-binding protein 3A"
FT /id="PRO_0000259597"
FT DOMAIN 832..899
FT /note="SH3 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT DOMAIN 995..1083
FT /note="Fibronectin type-III 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 1088..1184
FT /note="Fibronectin type-III 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 1452..1520
FT /note="SH3 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT DOMAIN 1569..1636
FT /note="SH3 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 215..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 295..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 697..811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1251..1273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1292..1330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 21..143
FT /evidence="ECO:0000255"
FT COILED 409..442
FT /evidence="ECO:0000255"
FT COILED 480..619
FT /evidence="ECO:0000255"
FT COMPBIAS 322..342
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 737..751
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 759..803
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1255..1273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1295..1321
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 1513
FT /note="R -> C (in dbSNP:rs374395444)"
FT /evidence="ECO:0000269|PubMed:11258795,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_028969"
FT CONFLICT 396
FT /note="A -> E (in Ref. 2; BAB33336)"
FT /evidence="ECO:0000305"
FT CONFLICT 437
FT /note="K -> E (in Ref. 2; BAB33336)"
FT /evidence="ECO:0000305"
FT CONFLICT 653
FT /note="S -> P (in Ref. 2; BAB33336)"
FT /evidence="ECO:0000305"
FT CONFLICT 882
FT /note="E -> D (in Ref. 2; BAB33336)"
FT /evidence="ECO:0000305"
FT CONFLICT 1307
FT /note="P -> T (in Ref. 4; AAH35246)"
FT /evidence="ECO:0000305"
FT CONFLICT 1314
FT /note="S -> Y (in Ref. 3; CAB61362 and 4; AAH35246)"
FT /evidence="ECO:0000305"
FT CONFLICT 1391
FT /note="W -> R (in Ref. 4; AAH35246)"
FT /evidence="ECO:0000305"
FT CONFLICT 1484
FT /note="R -> K (in Ref. 2; BAB33336)"
FT /evidence="ECO:0000305"
FT CONFLICT 1536
FT /note="N -> H (in Ref. 2; BAB33336, 3; CAB55970 and 4;
FT AAH35246)"
FT /evidence="ECO:0000305"
FT STRAND 1572..1578
FT /evidence="ECO:0007829|PDB:2EGE"
FT TURN 1582..1585
FT /evidence="ECO:0007829|PDB:2EGE"
FT STRAND 1589..1591
FT /evidence="ECO:0007829|PDB:2EGE"
FT STRAND 1602..1607
FT /evidence="ECO:0007829|PDB:2EGE"
FT STRAND 1614..1621
FT /evidence="ECO:0007829|PDB:2EGE"
FT STRAND 1623..1627
FT /evidence="ECO:0007829|PDB:2EGE"
FT TURN 1628..1630
FT /evidence="ECO:0007829|PDB:2EGE"
FT STRAND 1631..1633
FT /evidence="ECO:0007829|PDB:2EGE"
SQ SEQUENCE 1639 AA; 180717 MW; B1A465ECFDBE7903 CRC64;
MAKDSPSPLG ASPKKPGCSS PAAAVLENQR RELEKLRAEL EAERAGWRAE RRRFAARERQ
LREEAERERR QLADRLRSKW EAQRSRELRQ LQEEMQRERE AEIRQLLRWK EAEQRQLQQL
LHRERDGVVR QARELQRQLA EELVNRGHCS RPGASEVSAA QCRCRLQEVL AQLRWQTDGE
QAARIRYLQA ALEVERQLFL KYILAHFRGH PALSGSPDPQ AVHSLEEPLP QTSSGSCHAP
KPACQLGSLD SLSAEVGVRS RSLGLVSSAC SSSPDGLLST HASSLDCFAP ACSRSLDSTR
SLPKASKSEE RPSSPDTSTP GSRRLSPPPS PLPPPPPPSA HRKLSNPRGG EGSESQPCEV
LTPSPPGLGH HELIKLNWLL AKALWVLARR CYTLQAENKQ LRRAGCPYQA DEKVKRLKVK
RAELTGLARR LADRARKLQE TNLRAVSAPI PGESCAGLEL CQVFARQRAR DLSEQASAPL
AKDKQIEELR QECHLLQARV ASGPCSDLHT GRGGPCTQWL NVRDLDRLQR ESQREVLRLQ
RQLMLQQGNG GAWPEAGGQS ATCEEVRRQM LALERELDQR RRECQELGAQ AAPARRRGEE
AETQLQAALL KNAWLAEENG RLQAKTDWVR KVEAENSEVR GHLGRACQER DASGLIAEQL
LQQAARGQDR QQQLQRDPQK ALCDLHPSWK EIQALQCRPG HPPEQPWETS QMPESQVKGS
RRPKFHARPE DYAVSQPNRD IQEKREASLE ESPVALGESA SVPQVSETVP ASQPLSKKTS
SQSNSSSEGS MWATVPSSPT LDRDTASEVD DLEPDSVSLA LEMGGSAAPA APKLKIFMAQ
YNYNPFEGPN DHPEGELPLT AGDYIYIFGD MDEDGFYEGE LEDGRRGLVP SNFVEQIPDS
YIPGCLPAKS PDLGPSQLPA GQDEALEEDS LLSGKAQGVV DRGLCQMVRV GSKTEVATEI
LDTKTEACQL GLLQSMGKQG LSRPLLGTKG VLRMAPMQLH LQNVTATSAN ITWVYSSHRH
PHVVYLDDRE HALTPAGVSC YTFQGLCPGT HYRARVEVRL PRDLLQVYWG TMSSTVTFDT
LLAGPPYPPL DVLVERHASP GVLVVSWLPV TIDSAGSSNG VQVTGYAVYA DGLKVCEVAD
ATAGSTLLEF SQLQVPLTWQ KVSVRTMSLC GESLDSVPAQ IPEDFFMCHR WPETPPFSYT
CGDPSTYRVT FPVCPQKLSL APPSAKASPH NPGSCGEPQA KFLEAFFEEP PRRQSPVSNL
GSEGECPSSG AGSQAQELAE AWEGCRKDLL FQKSPQNHRP PSVSDQPGEK ENCSQHMGTS
KSPAPGFIHL RTECGPRKEP CQEKAALERV LRQKQDAQGF TPPQLGASQQ YASDFHNVLK
EEQEALCLDL WGTERREERR EPEPHSRQGQ ALGVKRGCQL HEPSSALCPA PSAKVIKMPR
GGPQQLGTGA NTPARVFVAL SDYNPLVMSA NLKAAEEELV FQKRQLLRVW GSQDTHDFYL
SECNRQVGNI PGRLVAEMEV GTEQTDRRWR SPAQGNLPSV AHLEDFQGLT IPQGSSLVLQ
GNSKRLPLWT PKIMIAALDY DPGDGQMGGQ GKGRLALRAG DVVMVYGPMD DQGFYYGELG
GHRGLVPAHL LDHMSLHGH
