RIMB1_MOUSE
ID RIMB1_MOUSE Reviewed; 1846 AA.
AC Q7TNF8; Q5NCP7; Q80TV9; Q8BIH5;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-JAN-2004, sequence version 2.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Peripheral-type benzodiazepine receptor-associated protein 1;
DE Short=PRAX-1;
DE AltName: Full=Peripheral benzodiazepine receptor-interacting protein;
DE Short=PBR-IP;
DE AltName: Full=RIMS-binding protein 1;
DE Short=RIM-BP1;
DE AltName: Full=TSPO-associated protein 1 {ECO:0000250|UniProtKB:O95153};
GN Name=Tspoap1 {ECO:0000250|UniProtKB:O95153};
GN Synonyms=Bzrap1, Kiaa0612, Rbp1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1184-1846 (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1481-1846 (ISOFORM 4).
RC TISSUE=Brain;
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=9915832; DOI=10.1074/jbc.274.5.2938;
RA Galiegue S., Jbilo O., Combes T., Bribes E., Carayon P., Le Fur G.,
RA Casellas P.;
RT "Cloning and characterization of PRAX-1. A new protein that specifically
RT interacts with the peripheral benzodiazepine receptor.";
RL J. Biol. Chem. 274:2938-2952(1999).
CC -!- SUBUNIT: Interacts with RIMS1, RIMS2 and TSPO. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Mitochondrion
CC {ECO:0000250}. Note=Preferentially expressed in the mitochondria in the
CC presence of TSPO. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q7TNF8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7TNF8-2; Sequence=VSP_009207;
CC Name=3;
CC IsoId=Q7TNF8-3; Sequence=VSP_009206, VSP_009210;
CC Name=4;
CC IsoId=Q7TNF8-4; Sequence=VSP_009208, VSP_009209;
CC -!- TISSUE SPECIFICITY: Predominantly expressed in the brain.
CC {ECO:0000269|PubMed:9915832}.
CC -!- DOMAIN: The SH3 and proline-rich domain is required for the interaction
CC with TSPO and the second SH3 domain mediates binding to a proline-rich
CC motif in RIMS1 and RIMS2. {ECO:0000250}.
CC -!- MISCELLANEOUS: [Isoform 4]: Due to intron retention. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the RIMBP family. {ECO:0000305}.
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DR EMBL; AK051895; BAC34805.1; -; mRNA.
DR EMBL; AL604022; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC055691; AAH55691.1; -; mRNA.
DR EMBL; AK122329; BAC65611.1; -; mRNA.
DR CCDS; CCDS48879.1; -. [Q7TNF8-1]
DR RefSeq; NP_766037.2; NM_172449.2. [Q7TNF8-1]
DR RefSeq; XP_006532773.1; XM_006532710.3. [Q7TNF8-2]
DR AlphaFoldDB; Q7TNF8; -.
DR SMR; Q7TNF8; -.
DR BioGRID; 228919; 1.
DR STRING; 10090.ENSMUSP00000048063; -.
DR iPTMnet; Q7TNF8; -.
DR PhosphoSitePlus; Q7TNF8; -.
DR PaxDb; Q7TNF8; -.
DR PRIDE; Q7TNF8; -.
DR ProteomicsDB; 255217; -. [Q7TNF8-1]
DR ProteomicsDB; 255218; -. [Q7TNF8-2]
DR ProteomicsDB; 255219; -. [Q7TNF8-3]
DR ProteomicsDB; 255220; -. [Q7TNF8-4]
DR Antibodypedia; 18369; 25 antibodies from 11 providers.
DR Ensembl; ENSMUST00000039627; ENSMUSP00000048063; ENSMUSG00000034156. [Q7TNF8-1]
DR GeneID; 207777; -.
DR KEGG; mmu:207777; -.
DR UCSC; uc007kum.2; mouse. [Q7TNF8-1]
DR UCSC; uc007kup.2; mouse. [Q7TNF8-3]
DR CTD; 9256; -.
DR MGI; MGI:2450877; Tspoap1.
DR VEuPathDB; HostDB:ENSMUSG00000034156; -.
DR eggNOG; KOG3632; Eukaryota.
DR GeneTree; ENSGT00950000183203; -.
DR HOGENOM; CLU_001979_1_0_1; -.
DR InParanoid; Q7TNF8; -.
DR OMA; CMQARVK; -.
DR OrthoDB; 102427at2759; -.
DR PhylomeDB; Q7TNF8; -.
DR TreeFam; TF316230; -.
DR Reactome; R-MMU-181429; Serotonin Neurotransmitter Release Cycle.
DR Reactome; R-MMU-181430; Norepinephrine Neurotransmitter Release Cycle.
DR Reactome; R-MMU-196108; Pregnenolone biosynthesis.
DR Reactome; R-MMU-210500; Glutamate Neurotransmitter Release Cycle.
DR Reactome; R-MMU-212676; Dopamine Neurotransmitter Release Cycle.
DR Reactome; R-MMU-264642; Acetylcholine Neurotransmitter Release Cycle.
DR BioGRID-ORCS; 207777; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Rbp1; mouse.
DR PRO; PR:Q7TNF8; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q7TNF8; protein.
DR Bgee; ENSMUSG00000034156; Expressed in superior colliculus and 139 other tissues.
DR ExpressionAtlas; Q7TNF8; baseline and differential.
DR Genevisible; Q7TNF8; MM.
DR GO; GO:0044305; C:calyx of Held; IDA:SynGO.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0098978; C:glutamatergic synapse; IDA:SynGO.
DR GO; GO:0005739; C:mitochondrion; ISO:MGI.
DR GO; GO:0030156; F:benzodiazepine receptor binding; ISO:MGI.
DR GO; GO:0099626; F:voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels; IDA:SynGO.
DR CDD; cd00063; FN3; 1.
DR CDD; cd12012; SH3_RIM-BP_2; 1.
DR CDD; cd12013; SH3_RIM-BP_3; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR035753; RIM-BP_SH3_2.
DR InterPro; IPR035755; RIM-BP_SH3_3.
DR InterPro; IPR040325; RIMBP1/2/3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR14234; PTHR14234; 1.
DR Pfam; PF07653; SH3_2; 2.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00326; SH3; 3.
DR SUPFAM; SSF49265; SSF49265; 1.
DR SUPFAM; SSF50044; SSF50044; 3.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50002; SH3; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Mitochondrion; Reference proteome; Repeat;
KW SH3 domain.
FT CHAIN 1..1846
FT /note="Peripheral-type benzodiazepine receptor-associated
FT protein 1"
FT /id="PRO_0000221381"
FT DOMAIN 649..716
FT /note="SH3 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT DOMAIN 787..878
FT /note="Fibronectin type-III 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 880..972
FT /note="Fibronectin type-III 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 977..1075
FT /note="Fibronectin type-III 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 1616..1684
FT /note="SH3 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT DOMAIN 1755..1822
FT /note="SH3 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT REGION 57..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 281..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 560..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 726..785
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1084..1107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1163..1219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1243..1302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1322..1476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1492..1617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1704..1755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1812..1846
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 596..619
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..760
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1251..1266
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1402..1418
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1501..1515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1546..1561
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..1631
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_009206"
FT VAR_SEQ 1289..1568
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_009207"
FT VAR_SEQ 1481..1568
FT /note="LSPKCLEISIEYDSEDEQEAGSGGVSINSSCYPTDGEAWGTAAVGRPRGPPK
FT VNPGPNAYLRLPAWEKGEPERRGRSAIGRTKEPPSR -> QETVLSHSPWPLQAPLLHS
FT SIGELGASARPSTVGVSGTSARLGQAPGEEFCAPVLMCCLRCRRGQSRGVWATTEDSVS
FT PLPSVALSLQ (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:12693553"
FT /id="VSP_009208"
FT VAR_SEQ 1803..1846
FT /note="GELNGQRGLVPSNFLEGPGPESGSLESGTSQAESQRTRRRRVQC -> VRSS
FT WGKEGVLCSGSPAGHAYGQTFLAEGWR (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:12693553"
FT /id="VSP_009209"
FT VAR_SEQ 1838..1846
FT /note="RTRRRRVQC -> DPRITIQGPPVPPGWHCALSSGSSSRTKLGESQSIAEKK
FT QGLLAKAKELLKRLGSRKD (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_009210"
FT CONFLICT 1715
FT /note="Y -> C (in Ref. 1; BAC34805)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1846 AA; 199929 MW; D53D1ED33376134D CRC64;
MEQLTTLPRL GDLGAMEPWA LPAWQHWTQG QGCKPGDASP SIAGTPTALQ VKGLRFEESS
KPEGAHSPGP VGNTDPEATE TGLPKLGQQA ESPGYSCSGL EEEEAQAYKA KFNIGFGDRP
NLELLRALGE LQQRCTILKE ENQMLRKSSF PETEEKVRRL KRKNAELAVI AKRLEERAQK
LQETNMRVVS APVPRPGSSL ELCRKALARQ RARDLSETAS ALLAKDKQIA ALQRECRELQ
ARLSLVGKEG PQWLHMRDFD RLLRESQREV LRLQRQIALR NQREPLRPAR SPGPTAPSRV
GAPAPGAPGE AVLQDDVESP QVVLREPEKQ QRVQQLESEL CKKRKKCESL EQEARKKQRR
CEELELQLRA AQNENARLVE ENSRLSGRAT EKEQVEWENS ELKGQLLGVT QERDSALLKS
QGLQSKLESL EQVLKHMREV AQRRQQLEVE HEQARLSLQE KQEEVRRLQQ AQAEAKREHE
GAVQLLESTL DSMQARVREL EGQCRSQTER FSLLAQELQA FRLHPGPLDL LTSALGCSAL
GDHPPPHCCC SIPQPCQGSG PKDLDLPPGS PGRCTPKSSE PALTTLTGIP RRTAKKAESL
SNSSRSESIH NSPKSCPTPE VDTASEVEEL EVDSVSLLPA APESHSGGAR IQVFLARYSY
NPFEGPNENP EAELPLTAGE YIYIYGNMDE DGFFEGELMD GRRGLVPSNF VERVSDDDLL
STLPRELADS SHSSGPELSF LSGGGGGCSS GGQSSGGRSQ PRPEEEAAGD ELSLSPPPEG
LGEPLAVPYP RHITVLKQLA HSVVLAWELP PERVDLRGFH IFVNGELRQA LGPGVPPKAV
LENMDLRTGP LHVSVQALTS KGSSDPLRCC LAVGAGAGVV PSQLRIHRLT ATSAEIAWVP
GNSNLAHAIY LNGEECPPAR PSTYWATFCN LRPGTLYQAR VEAQIPSQGP WEPGWERPEQ
RAATLQFTTL PAGLPDAPLD VQAEPGPSPG ILMISWLPVT IDAAGTSNGV RVTGYAIYAD
GQKIMEVASP TAGSVLVEVS QLQLLQACHE VTVRTMSPHG ESSDSIPAPV APALASACQP
ARMSCLSPRP SPEVRTPLAS VSPGLGDTSF PLRHPVPHGT QDFSASLSIE MSKGPQEEPP
VPCSQEEAGA AVRSISEEKR AIEPTLGQEG PEPVAPSLAK QEVECTSGDA GPVPCSTQGE
LTQKKPSIEA CHGGDLDSGL KLRSEKEDMS ELGVHLVNSL VDHSRNSDLS DIQEEEEEEE
EEEEELGSRP CSSQKQVAGN SIRENGAKPQ PDPFCETDSD EEILEQILEL PLQRLCSKKL
FSIPEEEEEE EEEEGLEKPG PSRTSQDPSQ PELALLGPGC DSSQPQGPGL CPLSPELSGV
REHLEDVLGV VGGNGRRRGG GSPEKLPNRK RPQDPREHCS RLLGNGGPQA SARPVPPRER
GSLPVIEGTR VGQEPGGRGR PGLSRRCPRG PAPESSLVSC LSPKCLEISI EYDSEDEQEA
GSGGVSINSS CYPTDGEAWG TAAVGRPRGP PKVNPGPNAY LRLPAWEKGE PERRGRSAIG
RTKEPPSRAT ETGESRGQDN SGRRGPQRRG ARVPRSGTTE LAPPRSPQEA PPHQDLPVRV
FVALFDYDPV SMSPNPDAGE EELPFKEGQL LKVFGDKDAD GFYRGESGGR TGYIPCNMVA
EVAVDSPAGR QQLLQRGFLP PNVLTEASGN GPSVYSSAHT PGPPPKPRRS KKVELEGPTQ
LCPGPPKLIH SAAQKTSRPM VAAFDYNPRE NSPNMDVEAE LPFRAGDVIT VFGNMDDDGF
YYGELNGQRG LVPSNFLEGP GPESGSLESG TSQAESQRTR RRRVQC
